ID   TF2H5_BOVIN             Reviewed;          71 AA.
AC   Q2T9Z5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=General transcription factor IIH subunit 5;
DE   AltName: Full=General transcription factor IIH polypeptide 5;
DE   AltName: Full=TFB5 ortholog {ECO:0000250|UniProtKB:Q6ZYL4};
DE   AltName: Full=TFIIH basal transcription factor complex TTD-A subunit {ECO:0000250|UniProtKB:Q6ZYL4};
DE   AltName: Full=TFIIH subunit p8 {ECO:0000250|UniProtKB:Q6ZYL4};
GN   Name=GTF2H5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the general transcription and DNA repair factor
CC       IIH (TFIIH) core complex, which is involved in general and
CC       transcription-coupled nucleotide excision repair (NER) of damaged DNA
CC       and, when complexed to CAK, in RNA transcription by RNA polymerase II.
CC       In NER, TFIIH acts by opening DNA around the lesion to allow the
CC       excision of the damaged oligonucleotide and its replacement by a new
CC       DNA fragment. In transcription, TFIIH has an essential role in
CC       transcription initiation. When the pre-initiation complex (PIC) has
CC       been established, TFIIH is required for promoter opening and promoter
CC       escape. Phosphorylation of the C-terminal tail (CTD) of the largest
CC       subunit of RNA polymerase II by the kinase module CAK controls the
CC       initiation of transcription. Necessary for the stability of the TFIIH
CC       complex and for the presence of normal levels of TFIIH in the cell.
CC       {ECO:0000250|UniProtKB:Q6ZYL4}.
CC   -!- SUBUNIT: Component of the 7-subunit TFIIH core complex composed of
CC       XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which
CC       is active in NER. The core complex associates with the 3-subunit CDK-
CC       activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and
CC       MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in
CC       transcription. {ECO:0000250|UniProtKB:Q6ZYL4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8K2X8}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8K2X8}.
CC   -!- SIMILARITY: Belongs to the TFB5 family. {ECO:0000305}.
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DR   EMBL; BC111195; AAI11196.1; -; mRNA.
DR   RefSeq; NP_001035627.1; NM_001040537.2.
DR   AlphaFoldDB; Q2T9Z5; -.
DR   SMR; Q2T9Z5; -.
DR   STRING; 9913.ENSBTAP00000011263; -.
DR   PaxDb; Q2T9Z5; -.
DR   PRIDE; Q2T9Z5; -.
DR   Ensembl; ENSBTAT00000011263; ENSBTAP00000011263; ENSBTAG00000008543.
DR   Ensembl; ENSBTAT00000073947; ENSBTAP00000058777; ENSBTAG00000008543.
DR   GeneID; 518046; -.
DR   KEGG; bta:518046; -.
DR   CTD; 404672; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008543; -.
DR   VGNC; VGNC:29698; GTF2H5.
DR   eggNOG; KOG3451; Eukaryota.
DR   GeneTree; ENSGT00390000004028; -.
DR   HOGENOM; CLU_166246_4_0_1; -.
DR   InParanoid; Q2T9Z5; -.
DR   OMA; IMENMNP; -.
DR   OrthoDB; 1591321at2759; -.
DR   TreeFam; TF319487; -.
DR   Proteomes; UP000009136; Chromosome 9.
DR   Bgee; ENSBTAG00000008543; Expressed in semen and 108 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005669; C:transcription factor TFIID complex; IEA:Ensembl.
DR   GO; GO:0000439; C:transcription factor TFIIH core complex; IBA:GO_Central.
DR   GO; GO:0005675; C:transcription factor TFIIH holo complex; IBA:GO_Central.
DR   GO; GO:0071480; P:cellular response to gamma radiation; IEA:Ensembl.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:Ensembl.
DR   GO; GO:0006294; P:nucleotide-excision repair, preincision complex assembly; IBA:GO_Central.
DR   GO; GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006362; P:transcription elongation from RNA polymerase I promoter; IEA:Ensembl.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro.
DR   Gene3D; 3.30.70.1220; -; 1.
DR   InterPro; IPR035935; TFB5-like_sf.
DR   InterPro; IPR009400; TFIIH_TTDA/Tfb5.
DR   PANTHER; PTHR28580; PTHR28580; 1.
DR   Pfam; PF06331; Tfb5; 1.
DR   SMART; SM01395; Tbf5; 1.
DR   SUPFAM; SSF142897; SSF142897; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..71
FT                   /note="General transcription factor IIH subunit 5"
FT                   /id="PRO_0000328422"
FT   MOD_RES         69
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6ZYL4"
SQ   SEQUENCE   71 AA;  8053 MW;  DBEB4D3C9BFA2C54 CRC64;
     MVNVLKGVLI ECDPAMKQFL LYLDESNALG KKFIIQDIDD THVFVIAELV NVLQERVGEL
     MDQNAFSLTQ K