TF2H5_CHICK
ID TF2H5_CHICK Reviewed; 71 AA.
AC Q5ZKH0;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=General transcription factor IIH subunit 5;
DE AltName: Full=General transcription factor IIH polypeptide 5;
DE AltName: Full=TFB5 ortholog {ECO:0000250|UniProtKB:Q6ZYL4};
DE AltName: Full=TFIIH basal transcription factor complex TTD-A subunit {ECO:0000250|UniProtKB:Q6ZYL4};
DE AltName: Full=TFIIH subunit p8 {ECO:0000250|UniProtKB:Q6ZYL4};
GN Name=GTF2H5; ORFNames=RCJMB04_10n20;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Component of the general transcription and DNA repair factor
CC IIH (TFIIH) core complex, which is involved in general and
CC transcription-coupled nucleotide excision repair (NER) of damaged DNA
CC and, when complexed to CAK, in RNA transcription by RNA polymerase II.
CC In NER, TFIIH acts by opening DNA around the lesion to allow the
CC excision of the damaged oligonucleotide and its replacement by a new
CC DNA fragment. In transcription, TFIIH has an essential role in
CC transcription initiation. When the pre-initiation complex (PIC) has
CC been established, TFIIH is required for promoter opening and promoter
CC escape. Phosphorylation of the C-terminal tail (CTD) of the largest
CC subunit of RNA polymerase II by the kinase module CAK controls the
CC initiation of transcription. {ECO:0000250|UniProtKB:Q6ZYL4}.
CC -!- SUBUNIT: Component of the 7-subunit TFIIH core complex composed of
CC XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which
CC is active in NER. The core complex associates with the 3-subunit CDK-
CC activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and
CC MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in
CC transcription. {ECO:0000250|UniProtKB:Q6ZYL4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8K2X8}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q8K2X8}.
CC -!- SIMILARITY: Belongs to the TFB5 family. {ECO:0000305}.
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DR EMBL; AJ720114; CAG31773.1; -; mRNA.
DR RefSeq; NP_001091004.1; NM_001097535.1.
DR RefSeq; XP_015139610.1; XM_015284124.1.
DR RefSeq; XP_015139611.1; XM_015284125.1.
DR RefSeq; XP_015139612.1; XM_015284126.1.
DR AlphaFoldDB; Q5ZKH0; -.
DR SMR; Q5ZKH0; -.
DR STRING; 9031.ENSGALP00000022280; -.
DR PaxDb; Q5ZKH0; -.
DR Ensembl; ENSGALT00000022319; ENSGALP00000022280; ENSGALG00000013733.
DR Ensembl; ENSGALT00000057922; ENSGALP00000048367; ENSGALG00000013733.
DR GeneID; 769754; -.
DR KEGG; gga:769754; -.
DR CTD; 404672; -.
DR VEuPathDB; HostDB:geneid_769754; -.
DR eggNOG; KOG3451; Eukaryota.
DR GeneTree; ENSGT00390000004028; -.
DR HOGENOM; CLU_166246_4_0_1; -.
DR InParanoid; Q5ZKH0; -.
DR OMA; IMENMNP; -.
DR OrthoDB; 1591321at2759; -.
DR PhylomeDB; Q5ZKH0; -.
DR TreeFam; TF319487; -.
DR Reactome; R-GGA-113418; Formation of the Early Elongation Complex.
DR Reactome; R-GGA-353303; Nucleotide Excision Repair.
DR Reactome; R-GGA-5696395; Formation of Incision Complex in GG-NER.
DR Reactome; R-GGA-5696400; Dual Incision in GG-NER.
DR Reactome; R-GGA-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-GGA-6781823; Formation of TC-NER Pre-Incision Complex.
DR Reactome; R-GGA-6782135; Dual incision in TC-NER.
DR Reactome; R-GGA-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR Reactome; R-GGA-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR Reactome; R-GGA-72086; mRNA Capping.
DR Reactome; R-GGA-73762; RNA Polymerase I Transcription Initiation.
DR Reactome; R-GGA-73772; RNA Polymerase I Promoter Escape.
DR Reactome; R-GGA-73776; RNA Polymerase II Promoter Escape.
DR Reactome; R-GGA-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR Reactome; R-GGA-73863; RNA Polymerase I Transcription Termination.
DR Reactome; R-GGA-75953; RNA Polymerase II Transcription Initiation.
DR Reactome; R-GGA-75955; RNA Polymerase II Transcription Elongation.
DR Reactome; R-GGA-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR Reactome; R-GGA-77075; RNA Pol II CTD phosphorylation and interaction with CE.
DR PRO; PR:Q5ZKH0; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000013733; Expressed in lung and 14 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0000439; C:transcription factor TFIIH core complex; IBA:GO_Central.
DR GO; GO:0005675; C:transcription factor TFIIH holo complex; IBA:GO_Central.
DR GO; GO:0006294; P:nucleotide-excision repair, preincision complex assembly; IBA:GO_Central.
DR GO; GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IBA:GO_Central.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro.
DR Gene3D; 3.30.70.1220; -; 1.
DR InterPro; IPR035935; TFB5-like_sf.
DR InterPro; IPR009400; TFIIH_TTDA/Tfb5.
DR PANTHER; PTHR28580; PTHR28580; 1.
DR Pfam; PF06331; Tfb5; 1.
DR SMART; SM01395; Tbf5; 1.
DR SUPFAM; SSF142897; SSF142897; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA repair; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..71
FT /note="General transcription factor IIH subunit 5"
FT /id="PRO_0000119258"
SQ SEQUENCE 71 AA; 8142 MW; C0F3AA032E2A3435 CRC64;
MVNVLKGVLI ECDPAMKQFL LYLDESNALG KKFIIQDLDE THVFVLAELV NFLQERVGEL
MDQNSFPITQ K
