ID   TF2H5_DICDI             Reviewed;          72 AA.
AC   Q55CT8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=General transcription factor IIH subunit 5;
DE   AltName: Full=TFIIH basal transcription factor complex subunit 5;
GN   Name=gtf2h5; Synonyms=tfiih5; ORFNames=DDB_G0269906;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the general transcription and DNA repair factor
CC       IIH (TFIIH) core complex, which is involved in general and
CC       transcription-coupled nucleotide excision repair (NER) of damaged DNA
CC       and, when complexed to CAK, in RNA transcription by RNA polymerase II.
CC       In NER, TFIIH acts by opening DNA around the lesion to allow the
CC       excision of the damaged oligonucleotide and its replacement by a new
CC       DNA fragment. In transcription, TFIIH has an essential role in
CC       transcription initiation. When the pre-initiation complex (PIC) has
CC       been established, TFIIH is required for promoter opening and promoter
CC       escape. Phosphorylation of the C-terminal tail (CTD) of the largest
CC       subunit of RNA polymerase II by the kinase module CAK controls the
CC       initiation of transcription. {ECO:0000250|UniProtKB:Q6ZYL4}.
CC   -!- SUBUNIT: Component of the 7-subunit TFIIH core complex composed of
CC       XPB/repB, XPD/repD, gtf2h1, gtf2h2, gtf2h3, gtf2h4 and gtf2h5, which is
CC       active in NER. The core complex associates with the 3-subunit CDK-
CC       activating kinase (CAK) module composed of cycH/cyclin H, cdk7 and
CC       mnat1 to form the 10-subunit holoenzyme (holo-TFIIH) active in
CC       transcription. {ECO:0000250|UniProtKB:Q6ZYL4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFB5 family. {ECO:0000305}.
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DR   EMBL; AAFI02000005; EAL72303.1; -; Genomic_DNA.
DR   RefSeq; XP_646393.1; XM_641301.1.
DR   AlphaFoldDB; Q55CT8; -.
DR   SMR; Q55CT8; -.
DR   STRING; 44689.DDB0266451; -.
DR   PaxDb; Q55CT8; -.
DR   EnsemblProtists; EAL72303; EAL72303; DDB_G0269906.
DR   GeneID; 8617348; -.
DR   KEGG; ddi:DDB_G0269906; -.
DR   dictyBase; DDB_G0269906; gtf2h5.
DR   eggNOG; ENOG502RHXG; Eukaryota.
DR   HOGENOM; CLU_166246_4_1_1; -.
DR   InParanoid; Q55CT8; -.
DR   OMA; PTKQFVE; -.
DR   PhylomeDB; Q55CT8; -.
DR   Reactome; R-DDI-113418; Formation of the Early Elongation Complex.
DR   Reactome; R-DDI-5696395; Formation of Incision Complex in GG-NER.
DR   Reactome; R-DDI-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-DDI-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-DDI-6782135; Dual incision in TC-NER.
DR   Reactome; R-DDI-6782210; Gap-filling DNA repair synthesis and ligation in TC-NER.
DR   Reactome; R-DDI-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR   Reactome; R-DDI-72086; mRNA Capping.
DR   Reactome; R-DDI-73772; RNA Polymerase I Promoter Escape.
DR   Reactome; R-DDI-73776; RNA Polymerase II Promoter Escape.
DR   Reactome; R-DDI-73779; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
DR   Reactome; R-DDI-75953; RNA Polymerase II Transcription Initiation.
DR   Reactome; R-DDI-75955; RNA Polymerase II Transcription Elongation.
DR   Reactome; R-DDI-76042; RNA Polymerase II Transcription Initiation And Promoter Clearance.
DR   Reactome; R-DDI-77075; RNA Pol II CTD phosphorylation and interaction with CE.
DR   PRO; PR:Q55CT8; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0000439; C:transcription factor TFIIH core complex; IBA:GO_Central.
DR   GO; GO:0005675; C:transcription factor TFIIH holo complex; IBA:GO_Central.
DR   GO; GO:0006294; P:nucleotide-excision repair, preincision complex assembly; IBA:GO_Central.
DR   GO; GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro.
DR   Gene3D; 3.30.70.1220; -; 1.
DR   InterPro; IPR035935; TFB5-like_sf.
DR   InterPro; IPR009400; TFIIH_TTDA/Tfb5.
DR   PANTHER; PTHR28580; PTHR28580; 1.
DR   Pfam; PF06331; Tfb5; 1.
DR   SMART; SM01395; Tbf5; 1.
DR   SUPFAM; SSF142897; SSF142897; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..72
FT                   /note="General transcription factor IIH subunit 5"
FT                   /id="PRO_0000328423"
SQ   SEQUENCE   72 AA;  8531 MW;  2F13DE1C6D919C82 CRC64;
     MVHVYKGLFL ECDPPTKQFV EYISKQEHFE VIVLDETHLF LQGGDEKVIN SIQRRIDDLQ
     NQNTYSVFDK DQ