TF2LX_HUMAN
ID TF2LX_HUMAN Reviewed; 241 AA.
AC Q8IUE1; Q5JRM9; Q8TD48;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Homeobox protein TGIF2LX;
DE AltName: Full=TGF-beta-induced transcription factor 2-like protein;
DE AltName: Full=TGFB-induced factor 2-like protein, X-linked;
DE AltName: Full=TGIF-like on the X;
GN Name=TGIF2LX; Synonyms=TGIFLX;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Testis;
RX PubMed=12226713; DOI=10.1007/s00335-002-3010-9;
RA Blanco-Arias P., Sargent C.A., Affara N.A.;
RT "The human-specific Yp11.2/Xq21.3 homology block encodes a potentially
RT functional testis-specific TGIF-like retroposon.";
RL Mamm. Genome 13:463-468(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ILE-197.
RX PubMed=12815422; DOI=10.1038/nature01722;
RA Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W.,
RA Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A.,
RA Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R.,
RA Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R.,
RA McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S.,
RA Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P.,
RA Waterston R.H., Wilson R.K., Rozen S., Page D.C.;
RT "The male-specific region of the human Y chromosome is a mosaic of discrete
RT sequence classes.";
RL Nature 423:825-837(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-197.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP STRUCTURE BY NMR OF 51-120.
RG RIKEN structural genomics initiative (RSGI);
RT "The solution structure of the homeobox domain of human homeobox protein
RT TGIF2LX.";
RL Submitted (OCT-2006) to the PDB data bank.
CC -!- FUNCTION: May have a transcription role in testis.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in adult testis.
CC -!- SIMILARITY: Belongs to the TALE/TGIF homeobox family. {ECO:0000305}.
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DR EMBL; AJ427749; CAD20750.1; -; Genomic_DNA.
DR EMBL; AF497480; AAM18073.1; -; mRNA.
DR EMBL; AL590041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117398; AAI17399.1; -; mRNA.
DR EMBL; BC117400; AAI17401.1; -; mRNA.
DR CCDS; CCDS14459.1; -.
DR RefSeq; NP_620410.3; NM_138960.3.
DR PDB; 2DMN; NMR; -; A=51-120.
DR PDBsum; 2DMN; -.
DR AlphaFoldDB; Q8IUE1; -.
DR BMRB; Q8IUE1; -.
DR SMR; Q8IUE1; -.
DR BioGRID; 124690; 34.
DR IntAct; Q8IUE1; 2.
DR STRING; 9606.ENSP00000453704; -.
DR GlyGen; Q8IUE1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8IUE1; -.
DR PhosphoSitePlus; Q8IUE1; -.
DR BioMuta; TGIF2LX; -.
DR DMDM; 44888510; -.
DR EPD; Q8IUE1; -.
DR MassIVE; Q8IUE1; -.
DR MaxQB; Q8IUE1; -.
DR PaxDb; Q8IUE1; -.
DR PeptideAtlas; Q8IUE1; -.
DR PRIDE; Q8IUE1; -.
DR ProteomicsDB; 70555; -.
DR Antibodypedia; 28433; 134 antibodies from 25 providers.
DR DNASU; 90316; -.
DR Ensembl; ENST00000283891.6; ENSP00000355119.4; ENSG00000153779.11.
DR Ensembl; ENST00000561129.2; ENSP00000453704.1; ENSG00000153779.11.
DR GeneID; 90316; -.
DR KEGG; hsa:90316; -.
DR MANE-Select; ENST00000283891.6; ENSP00000355119.4; NM_138960.4; NP_620410.3.
DR UCSC; uc004efe.4; human.
DR CTD; 90316; -.
DR DisGeNET; 90316; -.
DR GeneCards; TGIF2LX; -.
DR HGNC; HGNC:18570; TGIF2LX.
DR HPA; ENSG00000153779; Tissue enriched (testis).
DR MIM; 300411; gene.
DR neXtProt; NX_Q8IUE1; -.
DR OpenTargets; ENSG00000153779; -.
DR PharmGKB; PA38582; -.
DR VEuPathDB; HostDB:ENSG00000153779; -.
DR eggNOG; KOG0773; Eukaryota.
DR GeneTree; ENSGT00940000163848; -.
DR HOGENOM; CLU_034318_1_0_1; -.
DR InParanoid; Q8IUE1; -.
DR OMA; DPNQITM; -.
DR OrthoDB; 1221551at2759; -.
DR PhylomeDB; Q8IUE1; -.
DR TreeFam; TF318093; -.
DR PathwayCommons; Q8IUE1; -.
DR SignaLink; Q8IUE1; -.
DR BioGRID-ORCS; 90316; 12 hits in 641 CRISPR screens.
DR EvolutionaryTrace; Q8IUE1; -.
DR GenomeRNAi; 90316; -.
DR Pharos; Q8IUE1; Tbio.
DR PRO; PR:Q8IUE1; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8IUE1; protein.
DR Bgee; ENSG00000153779; Expressed in testis and 11 other tissues.
DR Genevisible; Q8IUE1; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..241
FT /note="Homeobox protein TGIF2LX"
FT /id="PRO_0000049324"
FT DNA_BIND 48..111
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..58
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 197
FT /note="V -> I (in dbSNP:rs2290380)"
FT /evidence="ECO:0000269|PubMed:12815422,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_017867"
FT HELIX 59..71
FT /evidence="ECO:0007829|PDB:2DMN"
FT TURN 72..75
FT /evidence="ECO:0007829|PDB:2DMN"
FT HELIX 80..90
FT /evidence="ECO:0007829|PDB:2DMN"
FT HELIX 94..107
FT /evidence="ECO:0007829|PDB:2DMN"
FT HELIX 109..112
FT /evidence="ECO:0007829|PDB:2DMN"
SQ SEQUENCE 241 AA; 26675 MW; A3E393E0BAD0B3BA CRC64;
MEAAADGPAE TQSPVEKDSP AKTQSPAQDT SIMSRNNADT GRVLALPEHK KKRKGNLPAE
SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLLQISNW FINARRRILP DMLQQRRNDP
IIGHKTGKDA HATHLQSTEA SVPAKSGPSG PDNVQSLPLW PLPKGQMSRE KQPDPESAPS
QKLTGIAQPK KKVKVSVTSP SSPELVSPEE HADFSSFLLL VDAAVQRAAE LELEKKQEPN
P
