ID   TF2LX_HYLLA             Reviewed;         241 AA.
AC   Q8MIE6;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Homeobox protein TGIF2LX;
DE   AltName: Full=TGF-beta-induced transcription factor 2-like protein;
DE   AltName: Full=TGFB-induced factor 2-like protein, X-linked;
DE   AltName: Full=TGIF-like on the X;
GN   Name=TGIF2LX; Synonyms=TGIFLX;
OS   Hylobates lar (Common gibbon) (White-handed gibbon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Hylobates.
OX   NCBI_TaxID=9580;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Blanco-Arias P.;
RT   "Characterisation of a TGIF-like protein gene in the human Xq21.3-Yp11.2
RT   homology block.";
RL   Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May have a transcription role in testis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the TALE/TGIF homeobox family. {ECO:0000305}.
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DR   EMBL; AJ345076; CAC87898.1; -; mRNA.
DR   AlphaFoldDB; Q8MIE6; -.
DR   SMR; Q8MIE6; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..241
FT                   /note="Homeobox protein TGIF2LX"
FT                   /id="PRO_0000049325"
FT   DNA_BIND        48..111
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          115..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..132
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   241 AA;  26360 MW;  BE1E249F0AC7DEB0 CRC64;
     MEAAADGSAE TQSPVEKDSP AKTQSPAQDT STVSRNSADT GKVLALPEHT KKPKGYLPAE
     SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLSQISNW FINARRRILP DMLKRHGNDP
     NIGHETGKDA HATHLQSTDA SVPAKSGPSG PENVQSLPVW PLPKGQMSGE KLPDPESAPS
     QNPTVIAQPK KKVKVSVTSP SSPEPVPPEE YPDFSSFQLL VDAAVQRAAE LELEKKQEPN
     P