ID   TF2LX_PANTR             Reviewed;         241 AA.
AC   Q8MIB7; A2T7D0;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 2.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Homeobox protein TGIF2LX;
DE   AltName: Full=TGF-beta-induced transcription factor 2-like protein;
DE   AltName: Full=TGFB-induced factor 2-like protein, X-linked;
DE   AltName: Full=TGIF-like on the X;
GN   Name=TGIF2LX; Synonyms=TGIFLX;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Blanco-Arias P.;
RT   "Characterisation of a TGIF-like protein gene in the human Xq21.3-Yp11.2
RT   homology block.";
RL   Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May have a transcription role in testis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the TALE/TGIF homeobox family. {ECO:0000305}.
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DR   EMBL; AJ345073; CAC87895.1; -; mRNA.
DR   EMBL; DQ977419; ABM92085.1; -; Genomic_DNA.
DR   RefSeq; NP_001009067.1; NM_001009067.1.
DR   AlphaFoldDB; Q8MIB7; -.
DR   BMRB; Q8MIB7; -.
DR   SMR; Q8MIB7; -.
DR   STRING; 9598.ENSPTRP00000037983; -.
DR   PaxDb; Q8MIB7; -.
DR   GeneID; 450174; -.
DR   KEGG; ptr:450174; -.
DR   CTD; 90316; -.
DR   eggNOG; KOG0773; Eukaryota.
DR   InParanoid; Q8MIB7; -.
DR   OrthoDB; 1221551at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..241
FT                   /note="Homeobox protein TGIF2LX"
FT                   /id="PRO_0000049329"
FT   DNA_BIND        48..111
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        64
FT                   /note="I -> V (in Ref. 1; ABM92085)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   241 AA;  26695 MW;  B5CA86641AEE30BF CRC64;
     MEAAADGPAE TQSPVQKDSP AKTQSPAQDT SIMSRNNADT GRVLALPEHK KKRKGNLPAE
     SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLLQISNW FINARRRILP DMLQQHRNDP
     IIGHKTGKDA HATHLQSTEA SVPAKSGPSG PDNVQSLPLW PLPKGQMSRE KQPDPESAPS
     QKLTGIAQPK KKVKVSITSP SSPELVSPEE YADFSSFLLL VDAAVQRAAE LELEKKQEPN
     P