TF2LY_HUMAN
ID TF2LY_HUMAN Reviewed; 185 AA.
AC Q8IUE0; A2VCU1;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Homeobox protein TGIF2LY;
DE AltName: Full=TGF-beta-induced transcription factor 2-like protein;
DE AltName: Full=TGFB-induced factor 2-like protein, Y-linked;
DE AltName: Full=TGIF-like on the Y;
GN Name=TGIF2LY; Synonyms=TGIFLY;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Testis;
RX PubMed=12226713; DOI=10.1007/s00335-002-3010-9;
RA Blanco-Arias P., Sargent C.A., Affara N.A.;
RT "The human-specific Yp11.2/Xq21.3 homology block encodes a potentially
RT functional testis-specific TGIF-like retroposon.";
RL Mamm. Genome 13:463-468(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=12815422; DOI=10.1038/nature01722;
RA Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W.,
RA Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A.,
RA Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R.,
RA Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R.,
RA McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S.,
RA Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P.,
RA Waterston R.H., Wilson R.K., Rozen S., Page D.C.;
RT "The male-specific region of the human Y chromosome is a mosaic of discrete
RT sequence classes.";
RL Nature 423:825-837(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May have a transcription role in testis. May act as a
CC competitor/regulator of TGIF2LX.
CC -!- INTERACTION:
CC Q8IUE0; Q9NS73-5: MBIP; NbExp=3; IntAct=EBI-8063723, EBI-10182361;
CC Q8IUE0; Q15742: NAB2; NbExp=6; IntAct=EBI-8063723, EBI-8641936;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in adult testis.
CC -!- SIMILARITY: Belongs to the TALE/TGIF homeobox family. {ECO:0000305}.
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DR EMBL; AJ427750; CAD20751.1; -; Genomic_DNA.
DR EMBL; AF332223; AAK13475.1; -; mRNA.
DR EMBL; AK292609; BAF85298.1; -; mRNA.
DR EMBL; BC128604; AAI28605.1; -; mRNA.
DR CCDS; CCDS14775.1; -.
DR RefSeq; NP_631960.1; NM_139214.2.
DR AlphaFoldDB; Q8IUE0; -.
DR BMRB; Q8IUE0; -.
DR SMR; Q8IUE0; -.
DR BioGRID; 124750; 32.
DR IntAct; Q8IUE0; 27.
DR MINT; Q8IUE0; -.
DR iPTMnet; Q8IUE0; -.
DR PhosphoSitePlus; Q8IUE0; -.
DR BioMuta; TGIF2LY; -.
DR DMDM; 44888509; -.
DR MassIVE; Q8IUE0; -.
DR MaxQB; Q8IUE0; -.
DR PaxDb; Q8IUE0; -.
DR PeptideAtlas; Q8IUE0; -.
DR PRIDE; Q8IUE0; -.
DR Antibodypedia; 5309; 99 antibodies from 21 providers.
DR DNASU; 90655; -.
DR Ensembl; ENST00000321217.5; ENSP00000318502.4; ENSG00000176679.9.
DR Ensembl; ENST00000559055.2; ENSP00000453750.1; ENSG00000176679.9.
DR GeneID; 90655; -.
DR KEGG; hsa:90655; -.
DR MANE-Select; ENST00000321217.5; ENSP00000318502.4; NM_139214.3; NP_631960.1.
DR UCSC; uc004fqk.4; human.
DR CTD; 90655; -.
DR GeneCards; TGIF2LY; -.
DR HGNC; HGNC:18569; TGIF2LY.
DR HPA; ENSG00000176679; Tissue enriched (testis).
DR MIM; 400025; gene.
DR neXtProt; NX_Q8IUE0; -.
DR PharmGKB; PA38581; -.
DR VEuPathDB; HostDB:ENSG00000176679; -.
DR GeneTree; ENSGT00940000163848; -.
DR HOGENOM; CLU_1460844_0_0_1; -.
DR InParanoid; Q8IUE0; -.
DR OMA; QERRYQS; -.
DR OrthoDB; 1221551at2759; -.
DR PhylomeDB; Q8IUE0; -.
DR TreeFam; TF318093; -.
DR PathwayCommons; Q8IUE0; -.
DR SignaLink; Q8IUE0; -.
DR BioGRID-ORCS; 90655; 9 hits in 634 CRISPR screens.
DR GenomeRNAi; 90655; -.
DR Pharos; Q8IUE0; Tdark.
DR PRO; PR:Q8IUE0; -.
DR Proteomes; UP000005640; Chromosome Y.
DR RNAct; Q8IUE0; protein.
DR Bgee; ENSG00000176679; Expressed in testis and 3 other tissues.
DR Genevisible; Q8IUE0; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..185
FT /note="Homeobox protein TGIF2LY"
FT /id="PRO_0000049332"
FT DNA_BIND 48..111
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..58
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 185 AA; 20814 MW; F02975B3EA9866F4 CRC64;
MEAAADGPAE TQSPVEKDSP AKTQSPAQDT SIMSRNNADT GRVLALPEHK KKRKGNLPAE
SVKILRDWMY KHRFKAYPSE EEKQMLSEKT NLSLLRISNW FINARRRILP DMLQQRRNDP
IIGHKTGKDA HATHLQSTEA SVPAKSGPVV QTMYKACPCG PCQRARCQER SNQIRSRPLA
RSSPE
