TF3A_ANAAE
ID TF3A_ANAAE Reviewed; 339 AA.
AC P34694;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Transcription factor IIIA;
DE Short=TFIIIA;
GN Name=gtf3a;
OS Anaxyrus americanus (American toad) (Bufo americanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Bufonidae; Anaxyrus.
OX NCBI_TaxID=8389;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Ovary;
RX PubMed=1398134; DOI=10.1016/0378-1119(92)90094-6;
RA Gaskins C.J., Smith J.F., Ogilvie M.K., Hanas J.S.;
RT "Comparison of the sequence and structure of transcription factor IIIA from
RT Bufo americanus and Rana pipiens.";
RL Gene 120:197-206(1992).
CC -!- FUNCTION: Involved in ribosomal large subunit biogenesis. Interacts
CC with the internal control region (ICR) of approximately 50 bases within
CC the 5S RNA genes, is required for correct transcription of these genes
CC by RNA polymerase III. Also binds the transcribed 5S RNA's.
CC {ECO:0000250|UniProtKB:P03001, ECO:0000250|UniProtKB:P17842,
CC ECO:0000250|UniProtKB:Q92664}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; X58366; CAA41259.1; -; mRNA.
DR PIR; JC1442; JC1442.
DR AlphaFoldDB; P34694; -.
DR SMR; P34694; -.
DR PRIDE; P34694; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Repeat; Ribosome biogenesis;
KW RNA-binding; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..339
FT /note="Transcription factor IIIA"
FT /id="PRO_0000047081"
FT ZN_FING 12..36
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 42..66
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 72..97
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 104..128
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 134..158
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 161..187
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 190..212
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 219..244
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 250..274
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 271..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 339 AA; 39500 MW; 24CE3252696183C8 CRC64;
MGEKLPVVYK RFICSFPDCN ATYNKNRKLQ AHLCKHTGER PFPCTYEGCE KGFVTLHHLN
RHVLSHTGEK PCKCETENCN LAFTTASNMR LHFKRAHSSP AQVYVCYFAD CGQQFRKHNQ
LKIHQYIHTN QQPFKCSHEG CDKCYASPSR LKRHEKTHAG YPCRKDSTCP FVGKTWSDYM
KHAAELHSEV TCSICNRTFK RKSFLKEHKK IHREERIVYR CPRENCDRTY TTKFNLKSHI
LTFHENLRPF VCEHEGCGKT FAMKQSLDRH FNTHDPEKKK MVKPPRPVRS LASRLSGYKP
KKSKKKKKPS QTPAMESQEQ QPDASKADPL PVLENLTLK
