ID   TF3A_CANAL              Reviewed;         412 AA.
AC   Q59KL6; A0A1D8PHA1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Transcription factor IIIA;
DE            Short=TFIIIA;
GN   Name=PZF1; OrderedLocusNames=CAALFM_C204860WA;
GN   ORFNames=CaO19.4125, orf19.4125;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   INDUCTION.
RX   PubMed=21592964; DOI=10.1074/jbc.m111.233569;
RA   Singh R.P., Prasad H.K., Sinha I., Agarwal N., Natarajan K.;
RT   "Cap2-HAP complex is a critical transcriptional regulator that has dual but
RT   contrasting roles in regulation of iron homeostasis in Candida albicans.";
RL   J. Biol. Chem. 286:25154-25170(2011).
RN   [5]
RP   INDUCTION.
RX   PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
RA   Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
RA   Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
RT   "A recently evolved transcriptional network controls biofilm development in
RT   Candida albicans.";
RL   Cell 148:126-138(2012).
CC   -!- FUNCTION: Transcription factor required for transcription of 5S rRNA by
CC       RNA polymerase III. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- INDUCTION: Expression is induced by HAP43 and during biofilm formation.
CC       {ECO:0000269|PubMed:21592964, ECO:0000269|PubMed:22265407}.
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DR   EMBL; CP017624; AOW27509.1; -; Genomic_DNA.
DR   RefSeq; XP_710284.1; XM_705192.2.
DR   AlphaFoldDB; Q59KL6; -.
DR   SMR; Q59KL6; -.
DR   BioGRID; 1231206; 1.
DR   STRING; 237561.Q59KL6; -.
DR   PRIDE; Q59KL6; -.
DR   GeneID; 3648113; -.
DR   KEGG; cal:CAALFM_C204860WA; -.
DR   CGD; CAL0000184073; PZF1.
DR   VEuPathDB; FungiDB:C2_04860W_A; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_044102_0_0_1; -.
DR   InParanoid; Q59KL6; -.
DR   OMA; ITHTKSF; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0001010; F:RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity; IEA:EnsemblFungi.
DR   GO; GO:0001002; F:RNA polymerase III type 1 promoter sequence-specific DNA binding; IEA:EnsemblFungi.
DR   GO; GO:0042791; P:5S class rRNA transcription by RNA polymerase III; IEA:EnsemblFungi.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00355; ZnF_C2H2; 9.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..412
FT                   /note="Transcription factor IIIA"
FT                   /id="PRO_0000426061"
FT   ZN_FING         25..49
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         55..79
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         85..107
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         111..136
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         140..162
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         169..194
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         197..219
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         228..252
FT                   /note="C2H2-type 8; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         345..369
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   412 AA;  47527 MW;  D2EE83D167162A4F CRC64;
     MSESDETKSI SSLISSSSSS RPKKYICTYE GCDKAYNRPS LLEQHLRTHS NDRPYKCTVE
     DCDKAFFRKS HLETHIVSHS EKKPFHCSVC GKGVNSRQHL KRHEITHTKS FKCTFENCQE
     AFYKHQSLRH HILSVHEKTL TCKQCNKVFT RPSKLAQHKL KHHGGSPAYQ CDHPGCFKNF
     QTWSVLQFHI KQSHPKLKCP KCGKGCVGKK GLSSHMLSHD DSTMIKIWTC DYCDVGKFAK
     KNELVEHYNI FHDGNIPDDL LKETEVKKLE NLLDQGSKLN NLHELETEKL KVEEDEEDEE
     DSLDEKRSDV RSDSMSAQRS IKSFTASLEG SKSVSKLISN SGKKINCPKN NCDRMFSREY
     DLRRHLKWHD DNLQRIESFL NSIEKEETPE GEPLVKKARM DLLPNETSVI SR