ID   TF3A_ICTPU              Reviewed;         322 AA.
AC   P79797;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Transcription factor IIIA;
DE            Short=TFIIIA;
GN   Name=gtf3a;
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=9426240; DOI=10.1016/s0378-1119(97)00499-x;
RA   Ogilvie M.K., Hanas J.S.;
RT   "Molecular biology of vertebrate transcription factor IIIA: cloning and
RT   characterization of TFIIIA from channel catfish oocytes.";
RL   Gene 203:103-112(1997).
CC   -!- FUNCTION: Involved in ribosomal large subunit biogenesis. Interacts
CC       with the internal control region (ICR) of approximately 50 bases within
CC       the 5S RNA genes, is required for correct transcription of these genes
CC       by RNA polymerase III. Also binds the transcribed 5S RNA's (By
CC       similarity). {ECO:0000250|UniProtKB:P03001,
CC       ECO:0000250|UniProtKB:P17842, ECO:0000250|UniProtKB:Q92664}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; Z68499; CAA92808.1; -; mRNA.
DR   RefSeq; NP_001187205.1; NM_001200276.1.
DR   AlphaFoldDB; P79797; -.
DR   SMR; P79797; -.
DR   STRING; 7998.ENSIPUP00000015796; -.
DR   GeneID; 100305039; -.
DR   KEGG; ipu:100305039; -.
DR   CTD; 100037394; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000221080; Chromosome 23.
DR   GO; GO:0005634; C:nucleus; IDA:AgBase.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:AgBase.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 9.
DR   SUPFAM; SSF57667; SSF57667; 5.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Repeat; Ribosome biogenesis;
KW   RNA-binding; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..322
FT                   /note="Transcription factor IIIA"
FT                   /id="PRO_0000047082"
FT   ZN_FING         12..36
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         42..64
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         70..95
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         102..126
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         132..156
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         159..184
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         188..211
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         218..243
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         249..273
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          272..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..292
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..322
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   322 AA;  37366 MW;  EC30CE6E858F8456 CRC64;
     MGERFKDPAK NFVCSFLNCK ASFSKAWKLE AHYCKHTGLR PFACDRCDKT FCTRCQLTRH
     NLSHSGKKPY QCLEDGCSES FISTAGLKNH VERVHQHKEK HYVCDYEGCA KEFRKKKQLR
     SHKCEHMNQL PFECQYEGCG KKYTTSKKLQ KHEKVHDVYP CAEEGCDFQG RMWTEYQAHR
     KAAHREALQC DSCAKVFHKA WFLKKHKLFV HLGVRRVFKC TKEGCQKTYT THFNLQNHIL
     SFHEGIRSFI CPHDGCGKAF AMEGSLKRHA VVHDPQKKKL QKKTKRGRKK KLEPKTNVSD
     DSELPAQLHG LSLNTSTSQN NP