TF3A_LITPI
ID TF3A_LITPI Reviewed; 335 AA.
AC P34695;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Transcription factor IIIA;
DE Short=TFIIIA;
GN Name=gtf3a;
OS Lithobates pipiens (Northern leopard frog) (Rana pipiens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX NCBI_TaxID=8404;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Ovary;
RX PubMed=1398134; DOI=10.1016/0378-1119(92)90094-6;
RA Gaskins C.J., Smith J.F., Ogilvie M.K., Hanas J.S.;
RT "Comparison of the sequence and structure of transcription factor IIIA from
RT Bufo americanus and Rana pipiens.";
RL Gene 120:197-206(1992).
CC -!- FUNCTION: Involved in ribosomal large subunit biogenesis. Interacts
CC with the internal control region (ICR) of approximately 50 bases within
CC the 5S RNA genes, is required for correct transcription of these genes
CC by RNA polymerase III. Also binds the transcribed 5S RNA's.
CC {ECO:0000250|UniProtKB:P03001, ECO:0000250|UniProtKB:P17842,
CC ECO:0000250|UniProtKB:Q92664}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; M85211; AAA49534.1; -; mRNA.
DR EMBL; X58369; CAA41260.1; -; mRNA.
DR PIR; JC1441; JC1441.
DR AlphaFoldDB; P34695; -.
DR SMR; P34695; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Repeat; Ribosome biogenesis;
KW RNA-binding; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..335
FT /note="Transcription factor IIIA"
FT /id="PRO_0000047083"
FT ZN_FING 13..37
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 43..67
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 73..98
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 105..129
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 135..159
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 162..188
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 192..214
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 221..246
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 252..276
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 269..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 335 AA; 38169 MW; E0B89EFD201DD288 CRC64;
MGEKATPAVY KRYICSFADC SASYNKNWKL QAHLCKHTGE RPFPCTVEGC GKGFVTLFHL
TRHSMTHTGE KPCKCDAPDC DLSFTTMTNL RKHYQRAHLS PSLIYECYFA DCGQTFKKHN
QLKLHQYIHT NQQPFKCNHE GCDKSFSSPS RLKRHEKVHA GYPCQKDSSC SFVGKTWTEY
MKHLAASHSE PTICDVCNRK FKNKTHLKDH KRTHEVERVV YKCPRDGCDR TYTKKFGLQS
HILSFHEDSR PFACGHPGCG KTFAMKQSLD RHANTHDPEK KKMKKPRPKK SLASRLSGYN
PKKLSKTPKS ASELGKLPPD GPPDTATAMQ NLSIK
