TF3A_SCHPO
ID TF3A_SCHPO Reviewed; 374 AA.
AC Q9UTL5;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 136.
DE RecName: Full=Transcription factor IIIA;
DE Short=TFIIIA;
GN Name=sfc2; ORFNames=SPAC144.09c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=12087160; DOI=10.1093/nar/gkf385;
RA Schulman D.B., Setzer D.R.;
RT "Identification and characterization of transcription factor IIIA from
RT Schizosaccharomyces pombe.";
RL Nucleic Acids Res. 30:2772-2781(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Is required for correct transcription of 5S RNA genes by RNA
CC polymerase III. Also binds the transcribed 5S RNA's. Initiates
CC transcription of the 5S ribosomal RNA gene.
CC {ECO:0000269|PubMed:12087160}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AY091590; AAM00046.1; -; mRNA.
DR EMBL; CU329670; CAB59689.1; -; Genomic_DNA.
DR PIR; T37676; T37676.
DR RefSeq; NP_594670.1; NM_001020099.2.
DR AlphaFoldDB; Q9UTL5; -.
DR SMR; Q9UTL5; -.
DR STRING; 4896.SPAC144.09c.1; -.
DR MaxQB; Q9UTL5; -.
DR PaxDb; Q9UTL5; -.
DR EnsemblFungi; SPAC144.09c.1; SPAC144.09c.1:pep; SPAC144.09c.
DR GeneID; 2542887; -.
DR KEGG; spo:SPAC144.09c; -.
DR PomBase; SPAC144.09c; sfc2.
DR VEuPathDB; FungiDB:SPAC144.09c; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_91_2_1; -.
DR InParanoid; Q9UTL5; -.
DR OMA; CNETFRK; -.
DR PhylomeDB; Q9UTL5; -.
DR Reactome; R-SPO-8951664; Neddylation.
DR Reactome; R-SPO-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:Q9UTL5; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0008097; F:5S rRNA binding; IDA:PomBase.
DR GO; GO:0003677; F:DNA binding; IDA:PomBase.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; IDA:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; IDA:PomBase.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW RNA-binding; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..374
FT /note="Transcription factor IIIA"
FT /id="PRO_0000047085"
FT ZN_FING 23..47
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 53..77
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 83..107
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 113..138
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 144..169
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 204..226
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 236..261
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 267..291
FT /note="C2H2-type 8; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 349..374
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 374 AA; 43851 MW; 7469C701FFF08FF6 CRC64;
MCHFNELSIE IESKNLRSAK KIFHCPYEEC GKKYSRPSLL EQHLRTHSNE RPFVCDYTGC
SKAFYRKSHL KIHKRCHTNV KPFSCHYDGC DAQFYTQQHL ERHIEVHRKP KPYACTWEGC
DECFSKHQQL RSHISACHTH LLPYPCTYQD CELRFATKQK LQNHVNRAHE KIISYSCPHE
SCVGHEGFEK WSQLQNHIRE AHVPSCSICG RQFKTAAHLR HHVVLHQTTL EERKTYHCPM
EGCKKSFTRS SALKKHISVI HEGNMAFHCD SCGTKFGYKH MLQRHLERGT CKKAHKPYIN
ECGIKHDGIE GVAIHDQKEK ELSSNLVSDV AKKIINEVTG HGYKEAREYS CSFPECNYRF
KRLYDMHRHL NSHH
