TF3C2_MOUSE
ID TF3C2_MOUSE Reviewed; 907 AA.
AC Q8BL74; Q3U7Z9; Q80XQ7; Q8BJJ4; Q8BLP3; Q8K1J1; Q9CSS0; Q9CVE6; Q9DBK6;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=General transcription factor 3C polypeptide 2;
DE AltName: Full=TF3C-beta;
DE AltName: Full=Transcription factor IIIC 110 kDa subunit;
DE Short=TFIIIC 110 kDa subunit;
DE Short=TFIIIC110;
DE AltName: Full=Transcription factor IIIC subunit beta;
GN Name=Gtf3c2; Synonyms=Kiaa0011;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Bone marrow, Brain cortex, Corpora quadrigemina, Embryo, and
RC Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Required for RNA polymerase III-mediated transcription.
CC Component of TFIIIC that initiates transcription complex assembly on
CC tRNA and is required for transcription of 5S rRNA and other stable
CC nuclear and cytoplasmic RNAs. May play a direct role in stabilizing
CC interactions of TFIIIC2 with TFIIIC1 (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of the TFIIIC subcomplex TFIIIC2, consisting of six
CC subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC31709.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=BAC97843.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK008582; BAB25760.1; -; mRNA.
DR EMBL; AK012095; BAB28026.1; -; mRNA.
DR EMBL; AK043944; BAC31709.1; ALT_SEQ; mRNA.
DR EMBL; AK046192; BAC32629.1; -; mRNA.
DR EMBL; AK083636; BAC38975.1; -; mRNA.
DR EMBL; AK151300; BAE30283.1; -; mRNA.
DR EMBL; AK152439; BAE31220.1; -; mRNA.
DR EMBL; AK129033; BAC97843.1; ALT_INIT; mRNA.
DR EMBL; BC034369; AAH34369.1; -; mRNA.
DR CCDS; CCDS39053.1; -.
DR RefSeq; NP_082177.2; NM_027901.2.
DR AlphaFoldDB; Q8BL74; -.
DR BioGRID; 214900; 16.
DR IntAct; Q8BL74; 14.
DR MINT; Q8BL74; -.
DR STRING; 10090.ENSMUSP00000085325; -.
DR iPTMnet; Q8BL74; -.
DR PhosphoSitePlus; Q8BL74; -.
DR EPD; Q8BL74; -.
DR jPOST; Q8BL74; -.
DR MaxQB; Q8BL74; -.
DR PaxDb; Q8BL74; -.
DR PeptideAtlas; Q8BL74; -.
DR PRIDE; Q8BL74; -.
DR ProteomicsDB; 259016; -.
DR DNASU; 71752; -.
DR Ensembl; ENSMUST00000088010; ENSMUSP00000085325; ENSMUSG00000106864.
DR GeneID; 71752; -.
DR KEGG; mmu:71752; -.
DR UCSC; uc008wxh.1; mouse.
DR CTD; 2976; -.
DR MGI; MGI:1919002; Gtf3c2.
DR VEuPathDB; HostDB:ENSMUSG00000106864; -.
DR eggNOG; ENOG502RAA6; Eukaryota.
DR GeneTree; ENSGT00390000018632; -.
DR HOGENOM; CLU_014720_0_0_1; -.
DR InParanoid; Q8BL74; -.
DR OMA; DKGFIWQ; -.
DR OrthoDB; 885702at2759; -.
DR PhylomeDB; Q8BL74; -.
DR TreeFam; TF314779; -.
DR Reactome; R-MMU-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-MMU-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR BioGRID-ORCS; 71752; 13 hits in 60 CRISPR screens.
DR ChiTaRS; Gtf3c2; mouse.
DR PRO; PR:Q8BL74; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8BL74; protein.
DR Bgee; ENSMUSG00000106864; Expressed in embryonic post-anal tail and 288 other tissues.
DR ExpressionAtlas; Q8BL74; baseline and differential.
DR Genevisible; Q8BL74; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0000127; C:transcription factor TFIIIC complex; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; ISO:MGI.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISO:MGI.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISO:MGI.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription;
KW WD repeat.
FT CHAIN 1..907
FT /note="General transcription factor 3C polypeptide 2"
FT /id="PRO_0000050986"
FT REPEAT 461..517
FT /note="WD 1"
FT REPEAT 548..589
FT /note="WD 2"
FT REPEAT 607..647
FT /note="WD 3"
FT REPEAT 828..870
FT /note="WD 4"
FT REGION 25..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..261
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 62
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUA4"
FT MOD_RES 130
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUA4"
FT MOD_RES 163
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUA4"
FT MOD_RES 219
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUA4"
FT MOD_RES 256
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUA4"
FT MOD_RES 593
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUA4"
FT MOD_RES 867
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUA4"
FT MOD_RES 888
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUA4"
FT MOD_RES 891
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUA4"
FT MOD_RES 897
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8WUA4"
FT CONFLICT 39
FT /note="S -> SS (in Ref. 3; AAH34369)"
FT /evidence="ECO:0000305"
FT CONFLICT 64
FT /note="D -> DK (in Ref. 3; AAH34369)"
FT /evidence="ECO:0000305"
FT CONFLICT 146
FT /note="K -> E (in Ref. 1; BAC31709)"
FT /evidence="ECO:0000305"
FT CONFLICT 392
FT /note="P -> Q (in Ref. 1; BAC32629)"
FT /evidence="ECO:0000305"
FT CONFLICT 622
FT /note="S -> N (in Ref. 1; BAC38975)"
FT /evidence="ECO:0000305"
FT CONFLICT 731
FT /note="P -> L (in Ref. 3; AAH34369)"
FT /evidence="ECO:0000305"
FT CONFLICT 815
FT /note="Q -> L (in Ref. 1; BAC38975)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 907 AA; 100275 MW; CEC3D374D3280CA7 CRC64;
MDTCGVGYVA LGEADPVGSM IVVDSPGQEE LSQLDVKASE TSGVEASIEM SLPPPLPGFE
DSSDRRLPPD QESLTRLEQQ DLSSEMSKVS NTRASKPSGR RGGRTARGAK RPQQRKPPST
PLVPGLLDQS NPLSTPMPKK RSQKSKGDLL LLKLSKGLDQ PESPHPKRPP EDFETPSGER
PRRRAAQVAL LYLQELAEEL STALPAPPLS GPKSPKVSSP TKPKKTRQAS SQGEEDGSAR
DEDFVLQVEG EDEEESEAPS ENSSDPEPVA PRSTPRGPAA GKQKPHCRGM APNGLPNYIM
APVWKCLHLT KDLREQHHSF WEFAEWIPVA WKWQLLSELE AAPYLPQEEK SPLFSVQREG
IPEDGTIYRI NRFSSITAHP ERWDVSFFTG GPLWALDWCP VPEGSAASQY VALFSSPDMN
ETHPLSQLHS GPGLLQLWGL GTLQQESCPG NRAHFVYGIA CDSGCIWDLK FCPSGAWEHP
ETLRKAPLLP RLGLLALACS DGKVLLFSLP HPEALLAQQP PDAMKPAIYK VQCLATLQVG
SVQASDPSEC GQCLSLAWMP TRPHHHLAAG YYNGMVVFWN LPTNSPLQRI RLSDGSLKLY
PFQCFLAHDQ AVRTIQWCKA NSHFLVSAGS DRKIKFWDLR RPYEPINCIK RFLSTELSWL
LPYNGVTVAQ DNCYASYGLC GIHYIDAGYL GFKAYFTAPR KGTVWSLSGS DWLGTVAAGD
ISGELIAAIL PDMASNPINV KKPAERRFPI YKADLIPYQD SPEDQDYSST SSETPNPPKA
RTYTETINHH YLLFQDTDLS SFHNLLRREP MLRMQEGEGH SQLCLDRLQL EAIHKVRFSP
NLDSYGWLVS GGQSGLVRIH FVRGLTSPLA HRVQLESRAN FNAMFQPSFP TEGPGFSPSS
HCLLPNP
