TF3C5_DICDI
ID TF3C5_DICDI Reviewed; 865 AA.
AC Q54GS8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=General transcription factor 3C polypeptide 5;
DE AltName: Full=TF3C-epsilon;
DE AltName: Full=Transcription factor IIIC subunit epsilon;
GN Name=gtf3c5; Synonyms=tfiiic5; ORFNames=DDB_G0289935;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Involved in RNA polymerase III-mediated transcription.
CC Integral, tightly associated component of the DNA-binding TFIIIC2
CC subcomplex that directly binds tRNA and virus-associated RNA promoters
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of the TFIIIC complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TFIIIC subunit 5 family. {ECO:0000305}.
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DR EMBL; AAFI02000149; EAL62480.1; -; Genomic_DNA.
DR RefSeq; XP_635991.1; XM_630899.1.
DR AlphaFoldDB; Q54GS8; -.
DR STRING; 44689.DDB0231091; -.
DR PaxDb; Q54GS8; -.
DR PRIDE; Q54GS8; -.
DR EnsemblProtists; EAL62480; EAL62480; DDB_G0289935.
DR GeneID; 8627406; -.
DR KEGG; ddi:DDB_G0289935; -.
DR dictyBase; DDB_G0289935; gtf3C5.
DR eggNOG; KOG2473; Eukaryota.
DR HOGENOM; CLU_331337_0_0_1; -.
DR InParanoid; Q54GS8; -.
DR OMA; YVCEGMA; -.
DR Reactome; R-DDI-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-DDI-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR PRO; PR:Q54GS8; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000127; C:transcription factor TFIIIC complex; ISS:dictyBase.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; IEA:InterPro.
DR Gene3D; 3.30.200.160; -; 1.
DR InterPro; IPR019136; TF_IIIC_su-5_HTH.
DR InterPro; IPR040454; TF_IIIC_Tfc1/Sfc1.
DR InterPro; IPR041499; Tfc1/Sfc1_N.
DR InterPro; IPR042536; TFIIIC_tauA_Sfc1.
DR PANTHER; PTHR13230; PTHR13230; 2.
DR Pfam; PF09734; Tau95; 1.
DR Pfam; PF17682; Tau95_N; 1.
PE 3: Inferred from homology;
KW DNA-binding; Nucleus; Reference proteome; Transcription.
FT CHAIN 1..865
FT /note="General transcription factor 3C polypeptide 5"
FT /id="PRO_0000328347"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..815
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..865
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 865 AA; 98963 MW; 13F7075345BA8D13 CRC64;
MNDETNKNNS NINNNNNNNN SSALVLVDNV RYDKAIIRPL PTKAYYGLEY PANVQNADKA
IESVGGLSKI SNVIKSREKE YLQLKFRPNN PTCKPTFGTK SPTCHLLLRV RPNKQQTQTQ
TQTQTQDNNE EMNSPKPTIQ SPKTTSRSKQ QQQQQQPQEN EKFDATIIAL VPSTIRFDGL
CDFQYLIKSD NNNTKSESDN VNDSSSSSSS KTVPITKQKD QYYVQQYSDN NEIMKDEPMN
LIPPLFSRID FPQNYLFKAN PNAQFDKTSK QFVFAKQTTR KATGHAKFNN VIPVAPQELP
KVFGVNELMK KTRDILVALF EKRPIWLYIS LLDKVQKEGG LVAHTKRVLP SLAFNFVDGP
WRKCWVKLGF DPRIHPETSQ YQTIDFRISE QDNHYPSNQP SKNNNNNNNN KDSIKNKEKD
NSNKEDKEHK EDKEDKQEED KENNETDNNE KSNKIDEESR DNTKNTDGGE DKNNKNIVEK
KNNNEKGDDN NIDDGDEIMK NKEDENGEGN NNNNNNNNNK EGVSEVQKLG RGHKDEKLII
QNGVSGETKI NPSRKKLLDI NTFEFNSQLP TSSSSLSSSS TQPLLLLKGG SGDDAQDFYQ
APVYDYTFKT APSMLSNLYQ IIDIEEPSIA EYWASVKIQS TCQKKFGWFS ESSFREGLER
MKARFGVMDN KMRFKSRSNT STATTTSTKS TQPKSTQPKE PKLKSTQPKE PRPKGRPRKY
AIKKDKNNNN NVDNNNDDSI DKMDLDDEET TTKSNKQNKE IDESLKNDTL AQMEKDNEYL
HGKNEEIEIE IDGGVVGGFD YDDDDDDEDK PFELLDDFDG TDNIQMKQID DFFGTQTNED
SEEDESDFDE EEEEEEEDFE FEESE
