TF3C5_MOUSE
ID TF3C5_MOUSE Reviewed; 520 AA.
AC Q8R2T8; Q8BLE3; Q8R0D0;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2004, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=General transcription factor 3C polypeptide 5;
DE AltName: Full=TF3C-epsilon;
DE AltName: Full=Transcription factor IIIC 63 kDa subunit;
DE Short=TFIIIC 63 kDa subunit;
DE Short=TFIIIC63;
DE AltName: Full=Transcription factor IIIC subunit epsilon;
GN Name=Gtf3c5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-520 (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Involved in RNA polymerase III-mediated transcription.
CC Integral, tightly associated component of the DNA-binding TFIIIC2
CC subcomplex that directly binds tRNA and virus-associated RNA promoters
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of the TFIIIC subcomplex TFIIIC2, consisting of six
CC subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts
CC with BRF1, GTF3C6 and TBP (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8R2T8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8R2T8-2; Sequence=VSP_010356;
CC -!- SIMILARITY: Belongs to the TFIIIC subunit 5 family. {ECO:0000305}.
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DR EMBL; BC027055; AAH27055.1; -; mRNA.
DR EMBL; BC027247; AAH27247.1; -; mRNA.
DR EMBL; BC039171; AAH39171.1; -; mRNA.
DR EMBL; AK045419; BAC32354.1; -; mRNA.
DR CCDS; CCDS15842.1; -. [Q8R2T8-2]
DR CCDS; CCDS71012.1; -. [Q8R2T8-1]
DR RefSeq; NP_001277413.1; NM_001290484.1. [Q8R2T8-1]
DR RefSeq; NP_683730.1; NM_148928.3. [Q8R2T8-2]
DR AlphaFoldDB; Q8R2T8; -.
DR SMR; Q8R2T8; -.
DR BioGRID; 213934; 1.
DR IntAct; Q8R2T8; 2.
DR MINT; Q8R2T8; -.
DR STRING; 10090.ENSMUSP00000028157; -.
DR iPTMnet; Q8R2T8; -.
DR PhosphoSitePlus; Q8R2T8; -.
DR EPD; Q8R2T8; -.
DR MaxQB; Q8R2T8; -.
DR PaxDb; Q8R2T8; -.
DR PRIDE; Q8R2T8; -.
DR ProteomicsDB; 263294; -. [Q8R2T8-1]
DR ProteomicsDB; 263295; -. [Q8R2T8-2]
DR Antibodypedia; 18242; 204 antibodies from 25 providers.
DR DNASU; 70239; -.
DR Ensembl; ENSMUST00000028157; ENSMUSP00000028157; ENSMUSG00000026816. [Q8R2T8-2]
DR Ensembl; ENSMUST00000113889; ENSMUSP00000109521; ENSMUSG00000026816. [Q8R2T8-1]
DR GeneID; 70239; -.
DR KEGG; mmu:70239; -.
DR UCSC; uc012bsz.2; mouse. [Q8R2T8-1]
DR CTD; 9328; -.
DR MGI; MGI:1917489; Gtf3c5.
DR VEuPathDB; HostDB:ENSMUSG00000026816; -.
DR eggNOG; KOG2473; Eukaryota.
DR GeneTree; ENSGT00390000004458; -.
DR HOGENOM; CLU_026463_0_0_1; -.
DR InParanoid; Q8R2T8; -.
DR OMA; PPEYFVR; -.
DR PhylomeDB; Q8R2T8; -.
DR TreeFam; TF313581; -.
DR Reactome; R-MMU-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-MMU-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR BioGRID-ORCS; 70239; 25 hits in 75 CRISPR screens.
DR ChiTaRS; Gtf3c5; mouse.
DR PRO; PR:Q8R2T8; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8R2T8; protein.
DR Bgee; ENSMUSG00000026816; Expressed in forelimb bud and 239 other tissues.
DR ExpressionAtlas; Q8R2T8; baseline and differential.
DR Genevisible; Q8R2T8; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0000127; C:transcription factor TFIIIC complex; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISO:MGI.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
DR GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; IEA:InterPro.
DR Gene3D; 3.30.200.160; -; 1.
DR InterPro; IPR019136; TF_IIIC_su-5_HTH.
DR InterPro; IPR040454; TF_IIIC_Tfc1/Sfc1.
DR InterPro; IPR041499; Tfc1/Sfc1_N.
DR InterPro; IPR042536; TFIIIC_tauA_Sfc1.
DR PANTHER; PTHR13230; PTHR13230; 1.
DR Pfam; PF09734; Tau95; 1.
DR Pfam; PF17682; Tau95_N; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; DNA-binding; Nucleus;
KW Reference proteome; Transcription.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9Y5Q8"
FT CHAIN 2..520
FT /note="General transcription factor 3C polypeptide 5"
FT /id="PRO_0000209716"
FT REGION 466..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..520
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y5Q8"
FT VAR_SEQ 465..470
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_010356"
FT CONFLICT 145
FT /note="M -> T (in Ref. 1; AAH27247)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 520 AA; 60502 MW; 02687D323638FD0B CRC64;
MAAAEPDADP KAAIPVDLRR ERRLVCVEYP GVVRNEAKML QTLGGEESVS RIYTDPTKRL
ELYFRPKDPY CHPVCANRFS TSSLLLRIRK RTRRRRGVLG DEAHPQVTFN LEIIGIISTI
YKFQGMSDFQ YLAVHTEAGG KHVSMYDRVL MRKPEKEEFF HQELPLYIPP PIFSRLDTPV
DYFYRPETQH REGYHNPTIS GENLIGLSRA RRPHNAIFVN FEDTEVPEQP LEAAVQTWKK
ACTNPIDQKV EEELRKLFDI RPVWSRNAVK SNVSVHPDKL KILLPYMAYY MITGPWRSLW
IRFGYDPRKH PDAKIYQVLD FRIRCGMKYG YGSRDMPVKA KRSTYNYSLP ITVKKTSNQP
GTMHDLKQGL GPSGTDGPRK LTYNKYKLKD SVYIFREGAL PPYRQMFYQL CDLNVEELQK
IVHRNDGTET VCTERDGWCL PKTTDHLRDT MSLMILQTIR SERPALFSNT GKADRGKEQL
MFESGEEEEE EEEEEEEEEE DFKPSDGSEN EMETEILDYV
