TF3C6_HUMAN
ID TF3C6_HUMAN Reviewed; 213 AA.
AC Q969F1; Q5VXN2;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=General transcription factor 3C polypeptide 6;
DE AltName: Full=Transcription factor IIIC 35 kDa subunit;
DE Short=TFIIIC 35 kDa subunit;
DE Short=TFIIIC35;
DE AltName: Full=Transcription factor IIIC subunit 6;
GN Name=GTF3C6; Synonyms=C6orf51; ORFNames=CDA020, NPD020;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, IDENTIFICATION IN TFIIIC2 COMPLEX,
RP INTERACTION WITH GTF3C4 AND GTF3C5, AND SUBCELLULAR LOCATION.
RX PubMed=17409385; DOI=10.1074/jbc.m611542200;
RA Dumay-Odelot H., Marck C., Durrieu-Gaillard S., Lefebvre O., Jourdain S.,
RA Prochazkova M., Pflieger A., Teichmann M.;
RT "Identification, molecular cloning, and characterization of the sixth
RT subunit of human transcription factor TFIIIC.";
RL J. Biol. Chem. 282:17179-17189(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pheochromocytoma, and Pituitary;
RA Liu F., Xu X.R., Qian B.Z., Xiao H., Chen Z., Han Z.;
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastric mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE
RP ANALYSIS] AT SER-9, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE
RP ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- FUNCTION: Involved in RNA polymerase III-mediated transcription.
CC Integral, tightly associated component of the DNA-binding TFIIIC2
CC subcomplex that directly binds tRNA and virus-associated RNA promoters.
CC {ECO:0000269|PubMed:17409385}.
CC -!- SUBUNIT: Part of the TFIIIC subcomplex TFIIIC2, consisting of six
CC subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts
CC with GTF3C4 and GTF3C5. {ECO:0000269|PubMed:17409385}.
CC -!- INTERACTION:
CC Q969F1; Q9H0A9-2: SPATC1L; NbExp=3; IntAct=EBI-6268616, EBI-11995806;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17409385}.
CC -!- SIMILARITY: Belongs to the TFIIIC subunit 6 family. {ECO:0000305}.
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DR EMBL; EF137904; ABO33431.1; -; mRNA.
DR EMBL; AF361492; AAL57217.1; -; mRNA.
DR EMBL; AF361496; AAL57221.1; -; mRNA.
DR EMBL; AK057977; BAB71624.1; -; mRNA.
DR EMBL; AL357515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW48305.1; -; Genomic_DNA.
DR EMBL; BC011593; AAH11593.1; -; mRNA.
DR CCDS; CCDS5087.1; -.
DR RefSeq; NP_612417.1; NM_138408.3.
DR AlphaFoldDB; Q969F1; -.
DR BioGRID; 125192; 25.
DR IntAct; Q969F1; 5.
DR STRING; 9606.ENSP00000357863; -.
DR iPTMnet; Q969F1; -.
DR PhosphoSitePlus; Q969F1; -.
DR BioMuta; GTF3C6; -.
DR DMDM; 30580360; -.
DR EPD; Q969F1; -.
DR jPOST; Q969F1; -.
DR MassIVE; Q969F1; -.
DR MaxQB; Q969F1; -.
DR PaxDb; Q969F1; -.
DR PeptideAtlas; Q969F1; -.
DR PRIDE; Q969F1; -.
DR ProteomicsDB; 75747; -.
DR Antibodypedia; 54521; 54 antibodies from 13 providers.
DR DNASU; 112495; -.
DR Ensembl; ENST00000329970.8; ENSP00000357863.4; ENSG00000155115.7.
DR GeneID; 112495; -.
DR KEGG; hsa:112495; -.
DR MANE-Select; ENST00000329970.8; ENSP00000357863.4; NM_138408.4; NP_612417.1.
DR UCSC; uc003pum.4; human.
DR CTD; 112495; -.
DR GeneCards; GTF3C6; -.
DR HGNC; HGNC:20872; GTF3C6.
DR HPA; ENSG00000155115; Low tissue specificity.
DR MIM; 611784; gene.
DR neXtProt; NX_Q969F1; -.
DR OpenTargets; ENSG00000155115; -.
DR PharmGKB; PA162390481; -.
DR VEuPathDB; HostDB:ENSG00000155115; -.
DR eggNOG; ENOG502RYMW; Eukaryota.
DR GeneTree; ENSGT00390000000510; -.
DR HOGENOM; CLU_106995_0_0_1; -.
DR InParanoid; Q969F1; -.
DR OMA; FEENTEH; -.
DR OrthoDB; 1477153at2759; -.
DR PhylomeDB; Q969F1; -.
DR TreeFam; TF329713; -.
DR PathwayCommons; Q969F1; -.
DR Reactome; R-HSA-749476; RNA Polymerase III Abortive And Retractive Initiation.
DR Reactome; R-HSA-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-HSA-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR SignaLink; Q969F1; -.
DR SIGNOR; Q969F1; -.
DR BioGRID-ORCS; 112495; 367 hits in 1085 CRISPR screens.
DR ChiTaRS; GTF3C6; human.
DR GenomeRNAi; 112495; -.
DR Pharos; Q969F1; Tdark.
DR PRO; PR:Q969F1; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q969F1; protein.
DR Bgee; ENSG00000155115; Expressed in gastrocnemius and 99 other tissues.
DR Genevisible; Q969F1; HS.
DR GO; GO:0016604; C:nuclear body; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0000127; C:transcription factor TFIIIC complex; IDA:HGNC-UCL.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; IDA:GO_Central.
DR GO; GO:0042791; P:5S class rRNA transcription by RNA polymerase III; IC:HGNC-UCL.
DR GO; GO:0006383; P:transcription by RNA polymerase III; IDA:HGNC-UCL.
DR GO; GO:0042797; P:tRNA transcription by RNA polymerase III; IC:HGNC-UCL.
DR InterPro; IPR042771; GTF3C6-like.
DR InterPro; IPR019481; TFIIIC_triple_barrel.
DR PANTHER; PTHR21860; PTHR21860; 1.
DR Pfam; PF10419; TFIIIC_sub6; 1.
PE 1: Evidence at protein level;
KW Acetylation; DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:21406692"
FT CHAIN 2..213
FT /note="General transcription factor 3C polypeptide 6"
FT /id="PRO_0000089507"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
SQ SEQUENCE 213 AA; 24049 MW; F2EC5E97B42B6FB5 CRC64;
MAAAADERSP EDGEDEEEEE QLVLVELSGI IDSDFLSKCE NKCKVLGIDT ERPILQVDSC
VFAGEYEDTL GTCVIFEENV EHADTEGNNK TVLKYKCHTM KKLSMTRTLL TEKKEGEENI
GGVEWLQIKD NDFSYRPNMI CNFLHENEDE EVVASAPDKS LELEEEEIQM NDSSNLSCEQ
EKPMHLEIED SGPLIDIPSE TEGSVFMETQ MLP
