TF3C6_MOUSE
ID TF3C6_MOUSE Reviewed; 227 AA.
AC Q9D8P7; Q8R2T6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=General transcription factor 3C polypeptide 6;
DE AltName: Full=Transcription factor IIIC 35 kDa subunit;
DE Short=TFIIIC 35 kDa subunit;
DE Short=TFIIIC35;
DE AltName: Full=Transcription factor IIIC subunit 6;
GN Name=Gtf3c6 {ECO:0000312|EMBL:AAH48446.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAB25281.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB25281.1}, and
RC DBA/2J {ECO:0000312|EMBL:BAE40045.1};
RC TISSUE=Muellerian duct {ECO:0000312|EMBL:BAE36699.1}, and
RC Pancreas {ECO:0000312|EMBL:BAB25281.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000312|EMBL:AAH48446.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II {ECO:0000312|EMBL:AAH27260.1};
RC TISSUE=Brain {ECO:0000312|EMBL:AAH48446.1}, and
RC Mammary tumor {ECO:0000312|EMBL:AAH27260.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in RNA polymerase III-mediated transcription.
CC Integral, tightly associated component of the DNA-binding TFIIIC2
CC subcomplex that directly binds tRNA and virus-associated RNA promoters
CC (By similarity). {ECO:0000250|UniProtKB:Q969F1}.
CC -!- SUBUNIT: Part of the TFIIIC subcomplex TFIIIC2, consisting of six
CC subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts
CC with GTF3C4 and GTF3C5 (By similarity). {ECO:0000250|UniProtKB:Q969F1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q969F1}.
CC -!- SIMILARITY: Belongs to the TFIIIC subunit 6 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK007816; BAB25281.1; -; mRNA.
DR EMBL; AK162053; BAE36699.1; -; mRNA.
DR EMBL; AK168070; BAE40045.1; -; mRNA.
DR EMBL; BC027260; AAH27260.1; -; mRNA.
DR EMBL; BC048446; AAH48446.1; -; mRNA.
DR CCDS; CCDS23794.1; -.
DR RefSeq; NP_080389.2; NM_026113.4.
DR AlphaFoldDB; Q9D8P7; -.
DR BioGRID; 212141; 6.
DR IntAct; Q9D8P7; 5.
DR STRING; 10090.ENSMUSP00000019982; -.
DR iPTMnet; Q9D8P7; -.
DR PhosphoSitePlus; Q9D8P7; -.
DR MaxQB; Q9D8P7; -.
DR PaxDb; Q9D8P7; -.
DR PeptideAtlas; Q9D8P7; -.
DR PRIDE; Q9D8P7; -.
DR ProteomicsDB; 262880; -.
DR Antibodypedia; 54521; 54 antibodies from 13 providers.
DR DNASU; 67371; -.
DR Ensembl; ENSMUST00000217537; ENSMUSP00000151091; ENSMUSG00000019837.
DR GeneID; 67371; -.
DR KEGG; mmu:67371; -.
DR UCSC; uc007ewr.1; mouse.
DR CTD; 112495; -.
DR MGI; MGI:1914621; Gtf3c6.
DR VEuPathDB; HostDB:ENSMUSG00000019837; -.
DR eggNOG; ENOG502RYMW; Eukaryota.
DR GeneTree; ENSGT00390000000510; -.
DR HOGENOM; CLU_106995_0_0_1; -.
DR InParanoid; Q9D8P7; -.
DR OMA; FEENTEH; -.
DR OrthoDB; 1477153at2759; -.
DR PhylomeDB; Q9D8P7; -.
DR TreeFam; TF329713; -.
DR Reactome; R-MMU-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-MMU-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR BioGRID-ORCS; 67371; 14 hits in 73 CRISPR screens.
DR ChiTaRS; Gtf3c6; mouse.
DR PRO; PR:Q9D8P7; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9D8P7; protein.
DR Bgee; ENSMUSG00000019837; Expressed in dorsal pancreas and 252 other tissues.
DR ExpressionAtlas; Q9D8P7; baseline and differential.
DR Genevisible; Q9D8P7; MM.
DR GO; GO:0016604; C:nuclear body; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0000127; C:transcription factor TFIIIC complex; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; ISO:MGI.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISO:MGI.
DR GO; GO:0006383; P:transcription by RNA polymerase III; ISO:MGI.
DR InterPro; IPR042771; GTF3C6-like.
DR InterPro; IPR019481; TFIIIC_triple_barrel.
DR PANTHER; PTHR21860; PTHR21860; 1.
DR Pfam; PF10419; TFIIIC_sub6; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription.
FT CHAIN 1..227
FT /note="General transcription factor 3C polypeptide 6"
FT /id="PRO_0000314059"
FT REGION 157..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..198
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 227 AA; 25548 MW; EFC2EC1A5968E8FB CRC64;
MASPNAMAAA VDPIWEDLEE EEEELEEEQF VLVELSGIID SDFLSKCENK CKILGIDTER
PIMQVDSYVF AGEYEDTLGT CVIFEEGVER VDPEGTDKTV LKYKCHTMKK LSMTRTLLTE
KKEGEENIDG VEWLQMKDND FSYRPNMICS FLHEHEDEAA GPASDKPVEL EDQESQMKGS
AEQTQEQEKV EHSEVEDPAP SGETPSEMES SVFMGTQDGN VSQNNQS
