ID   BRD7_CHICK              Reviewed;         651 AA.
AC   Q5ZKG2;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Bromodomain-containing protein 7;
GN   Name=BRD7; ORFNames=RCJMB04_11a18;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Acts both as coactivator and as corepressor. May play a role
CC       in chromatin remodeling. Participates in the Wnt signaling pathway.
CC       Transcriptional corepressor that down-regulates the expression of
CC       target genes. Binds to target promoters, leading to increased histone
CC       H3 acetylation. Coactivator for TP53-mediated activation of
CC       transcription of a set of target genes. Required for TP53-mediated
CC       cell-cycle arrest in response to oncogene activation. Inhibits cell
CC       cycle progression from G1 to S phase (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; AJ720122; CAG31781.1; -; mRNA.
DR   RefSeq; NP_001005839.1; NM_001005839.1.
DR   AlphaFoldDB; Q5ZKG2; -.
DR   SMR; Q5ZKG2; -.
DR   STRING; 9031.ENSGALP00000005996; -.
DR   PaxDb; Q5ZKG2; -.
DR   GeneID; 415730; -.
DR   KEGG; gga:415730; -.
DR   CTD; 29117; -.
DR   VEuPathDB; HostDB:geneid_415730; -.
DR   eggNOG; KOG1828; Eukaryota.
DR   InParanoid; Q5ZKG2; -.
DR   OrthoDB; 439339at2759; -.
DR   PhylomeDB; Q5ZKG2; -.
DR   PRO; PR:Q5ZKG2; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0070577; F:lysine-acetylated histone binding; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.920.10; -; 1.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR021900; DUF3512.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF12024; DUF3512; 1.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00297; BROMO; 1.
DR   SUPFAM; SSF47370; SSF47370; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
PE   2: Evidence at transcript level;
KW   Bromodomain; Cell cycle; Coiled coil; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Tumor suppressor;
KW   Wnt signaling pathway.
FT   CHAIN           1..651
FT                   /note="Bromodomain-containing protein 7"
FT                   /id="PRO_0000227667"
FT   DOMAIN          148..218
FT                   /note="Bromo"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT   REGION          36..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          257..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          533..564
FT                   /evidence="ECO:0000255"
FT   MOTIF           65..96
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        90..107
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..133
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   651 AA;  74022 MW;  44318F8C16BC1DFC CRC64;
     MGKKHKKHKS DKHPYEEYVE KPLKLVLKVG GNEVAELSTG SAGLDSSLYE DKSEHEKHKD
     RKRKKRKKGE KQVPGEEKEK RKRKVKEDKR KRDREHPDSE GEQELRCQTP IRLELSPEKP
     LTSSLSKQEE VEQTPLQEAL NQLMRQLQRK DPSSFFSFPV TDFIAPGYSM IIKNPMDFST
     MKEKIKNNGY QSIEELKDNF KLMCTNAMTY NKPDTIYYKA AKKLLHSGMK ILSQERIQSL
     KQSIEFMADL QKTRKQKDKV ELQLSGEDES GSGKDKGEPV DGDTKAFKTP NKEHKKKDKD
     LLEDKLRINS LEREQEQIDR IVRESGGKLT RRLANSQCEF ERRKPDGTTT LGLLNPVDLT
     AGEAGYCPVK LGMTAGRLQS GVNMLQGFKE DKRNKVTPVT YLNYGPYSSY APTYDSTFAN
     ISKEDSDLIY STYGEDSNQG SFSIHEFLMK SQDYPFLMAD SLLDVLTKGG HSRSLRELET
     PLEEDEGPHE RSDALKEIME IDIAARLDSA NNDRLTALKA VTNFGMPMEE FDSEEAEIFQ
     RKLDETTKLL RELQDAQNER LSTKPPPNMI CLLGPSYREM HLAERVTNNL KELAQQVTPG
     DIVSTYGIRK AMGISIPLPD IGDSGVDLTD EFQEPKKTVT ITENECGPVT V