ID   TFB2_DEBHA              Reviewed;         515 AA.
AC   Q6BGW8; B5RUZ8;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=General transcription and DNA repair factor IIH subunit TFB2;
DE            Short=TFIIH subunit TFB2;
DE   AltName: Full=RNA polymerase II transcription factor B subunit 2;
GN   Name=TFB2; OrderedLocusNames=DEHA2G23254g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the general transcription and DNA repair factor
CC       IIH (TFIIH) core complex, which is involved in general and
CC       transcription-coupled nucleotide excision repair (NER) of damaged DNA
CC       and, when complexed to TFIIK, in RNA transcription by RNA polymerase
CC       II. In NER, TFIIH acts by opening DNA around the lesion to allow the
CC       excision of the damaged oligonucleotide and its replacement by a new
CC       DNA fragment. In transcription, TFIIH has an essential role in
CC       transcription initiation. When the pre-initiation complex (PIC) has
CC       been established, TFIIH is required for promoter opening and promoter
CC       escape. Phosphorylation of the C-terminal tail (CTD) of the largest
CC       subunit of RNA polymerase II by the kinase module TFIIK controls the
CC       initiation of transcription. {ECO:0000250|UniProtKB:Q02939}.
CC   -!- SUBUNIT: Component of the 7-subunit TFIIH core complex composed of
CC       XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in
CC       NER. The core complex associates with the 3-subunit CTD-kinase module
CC       TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit
CC       holoenzyme (holo-TFIIH) active in transcription.
CC       {ECO:0000250|UniProtKB:Q02939}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFB2 family. {ECO:0000305}.
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DR   EMBL; CR382139; CAR66042.1; -; Genomic_DNA.
DR   RefSeq; XP_002777731.1; XM_002777685.1.
DR   AlphaFoldDB; Q6BGW8; -.
DR   SMR; Q6BGW8; -.
DR   STRING; 4959.XP_002777731.1; -.
DR   EnsemblFungi; CAR66042; CAR66042; DEHA2G23254g.
DR   GeneID; 8999303; -.
DR   KEGG; dha:DEHA2G23254g; -.
DR   VEuPathDB; FungiDB:DEHA2G23254g; -.
DR   eggNOG; KOG3471; Eukaryota.
DR   HOGENOM; CLU_027280_4_0_1; -.
DR   InParanoid; Q6BGW8; -.
DR   OMA; LWENERN; -.
DR   OrthoDB; 466731at2759; -.
DR   Proteomes; UP000000599; Chromosome G.
DR   GO; GO:0000439; C:transcription factor TFIIH core complex; IEA:InterPro.
DR   GO; GO:0001671; F:ATPase activator activity; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   InterPro; IPR040662; Tfb2_C.
DR   InterPro; IPR004598; TFIIH_p52/Tfb2.
DR   PANTHER; PTHR13152; PTHR13152; 1.
DR   Pfam; PF03849; Tfb2; 1.
DR   Pfam; PF18307; Tfb2_C; 1.
DR   TIGRFAMs; TIGR00625; tfb2; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..515
FT                   /note="General transcription and DNA repair factor IIH
FT                   subunit TFB2"
FT                   /id="PRO_0000119264"
SQ   SEQUENCE   515 AA;  58233 MW;  DF2C56B1E6F70B11 CRC64;
     MSSSNLFKAT VNEHLEGLPK QVQSRLYEAP ATCLSIYRLL PPIAKFYIMT MLFYETPVAL
     KDLDKWCKPT SRKFQFDSLK RLRALHLIEE DSSGSHIRLH PTFRQNFRDC LTGSQARNAF
     GNLSTTPDEQ SVSIKFLDSF ALQKWESILH FMVGTELSVT PSNSVLSLLK SGGLMEGTNK
     GGNRLNITNS GFQFLLQDIN AQIWTLLLQY LNLTQDLNMD PVDVLNFIFI LGSLELGKGY
     TVSSLSETQI SMLADLRDYG LIYQRSENSE RFYPTRLATT LTSDSAALKS PSMAMEQALE
     STTETEEQQN LASNSNQGTI ILETNFKIYA YTNSPLEIAI LNLFVHLKTR FSNMVCGQIT
     RESIRNALYN GITADQIIKF LETHAHSQMK ILAKERLDKK IEFDTSNNIN TAGGAPQSQM
     MTNENGTTVA QHKLEVLPPT VVDQIKLWQL ELDRIQTFEG YLFKDFASQQ EFEALSNYAS
     EIGVLLWSNK SKMKFFVTKD GISQVADFAS RNQRR