ID   TFB2_YARLI              Reviewed;         467 AA.
AC   Q6BZX4;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=General transcription and DNA repair factor IIH subunit TFB2;
DE            Short=TFIIH subunit TFB2;
DE   AltName: Full=RNA polymerase II transcription factor B subunit 2;
GN   Name=TFB2; OrderedLocusNames=YALI0F30173g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the general transcription and DNA repair factor
CC       IIH (TFIIH) core complex, which is involved in general and
CC       transcription-coupled nucleotide excision repair (NER) of damaged DNA
CC       and, when complexed to TFIIK, in RNA transcription by RNA polymerase
CC       II. In NER, TFIIH acts by opening DNA around the lesion to allow the
CC       excision of the damaged oligonucleotide and its replacement by a new
CC       DNA fragment. In transcription, TFIIH has an essential role in
CC       transcription initiation. When the pre-initiation complex (PIC) has
CC       been established, TFIIH is required for promoter opening and promoter
CC       escape. Phosphorylation of the C-terminal tail (CTD) of the largest
CC       subunit of RNA polymerase II by the kinase module TFIIK controls the
CC       initiation of transcription. {ECO:0000250|UniProtKB:Q02939}.
CC   -!- SUBUNIT: Component of the 7-subunit TFIIH core complex composed of
CC       XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in
CC       NER. The core complex associates with the 3-subunit CTD-kinase module
CC       TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit
CC       holoenzyme (holo-TFIIH) active in transcription.
CC       {ECO:0000250|UniProtKB:Q02939}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFB2 family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG78851.1; -; Genomic_DNA.
DR   RefSeq; XP_506038.1; XM_506038.1.
DR   AlphaFoldDB; Q6BZX4; -.
DR   SMR; Q6BZX4; -.
DR   STRING; 4952.CAG78851; -.
DR   EnsemblFungi; CAG78851; CAG78851; YALI0_F30173g.
DR   GeneID; 2908598; -.
DR   KEGG; yli:YALI0F30173g; -.
DR   VEuPathDB; FungiDB:YALI0_F30173g; -.
DR   HOGENOM; CLU_027280_4_0_1; -.
DR   InParanoid; Q6BZX4; -.
DR   OMA; LWENERN; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0000439; C:transcription factor TFIIH core complex; IBA:GO_Central.
DR   GO; GO:0005675; C:transcription factor TFIIH holo complex; IBA:GO_Central.
DR   GO; GO:0001671; F:ATPase activator activity; IEA:InterPro.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; IBA:GO_Central.
DR   GO; GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IBA:GO_Central.
DR   InterPro; IPR040662; Tfb2_C.
DR   InterPro; IPR004598; TFIIH_p52/Tfb2.
DR   PANTHER; PTHR13152; PTHR13152; 1.
DR   Pfam; PF03849; Tfb2; 1.
DR   Pfam; PF18307; Tfb2_C; 1.
DR   TIGRFAMs; TIGR00625; tfb2; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..467
FT                   /note="General transcription and DNA repair factor IIH
FT                   subunit TFB2"
FT                   /id="PRO_0000119267"
SQ   SEQUENCE   467 AA;  52631 MW;  7216F3E5C711DABD CRC64;
     MTSQFKNSIN DYLEGLPEAV LTRLYQSPAT CLAVFRLLPA LARTLIMGMI FNPDPIAVAD
     VDALVKPSSQ RLKLETQKKL RLLHIFTETQ AHIIINPTFK KNLRAALVGG DQNISFGVPC
     DTEDKHKVDV AFLDAHAVSQ WEMILHFMVG TSIGRTPSDG VLNLLKHSGL MEPERGGLRI
     TNAGFQFLLQ DVNAQIWTLL LQYLNMSEYL QMDPVDVLNF IFMLGSLELG QDYSLSALSE
     TQKHMLEDLR DYGIVYQRKA SSRRFYPTRL ATTLTSETAA LRTASQSMEA ATQDTISSSV
     AADSGFIILE TNFRLYAYTE SPLQIAVLNL FVNLKTRFAN MVTGQINRDS VRFALSNGIT
     AEQIITYLSV HAHPRMKGME HVLPPTVVDQ IKLWQLEMDR IRATDGYLFS EFKNFDEYKD
     VSTYAKELGV LLYENPGKRK FVSTLAGSQQ IVEFVKRRNQ KHRSSAN