TFB3_ASHGO
ID TFB3_ASHGO Reviewed; 318 AA.
AC Q75D20;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=RNA polymerase II transcription factor B subunit 3;
DE AltName: Full=RNA polymerase II transcription factor B 38 kDa subunit;
DE AltName: Full=RNA polymerase II transcription factor B p38 subunit;
GN Name=TFB3; OrderedLocusNames=ABR202C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Acts as component of the general transcription and DNA repair
CC factor IIH (TFIIH or factor B), which is essential for both basal and
CC activated transcription, and is involved in nucleotide excision repair
CC (NER) of damaged DNA. TFIIH as CTD kinase activity and DNA-dependent
CC ATPase activity, and is essential for polymerase II transcription (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AE016815; AAS50975.1; -; Genomic_DNA.
DR RefSeq; NP_983151.1; NM_208504.1.
DR AlphaFoldDB; Q75D20; -.
DR SMR; Q75D20; -.
DR STRING; 33169.AAS50975; -.
DR EnsemblFungi; AAS50975; AAS50975; AGOS_ABR202C.
DR GeneID; 4619261; -.
DR KEGG; ago:AGOS_ABR202C; -.
DR eggNOG; KOG3800; Eukaryota.
DR HOGENOM; CLU_048466_1_1_1; -.
DR InParanoid; Q75D20; -.
DR OMA; PANCPVA; -.
DR Proteomes; UP000000591; Chromosome II.
DR GO; GO:0005675; C:transcription factor TFIIH holo complex; IBA:GO_Central.
DR GO; GO:0070985; C:transcription factor TFIIK complex; IEA:EnsemblFungi.
DR GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IEA:EnsemblFungi.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:EnsemblFungi.
DR GO; GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IEA:EnsemblFungi.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR015877; Cdk-activating_kinase_MAT1_cen.
DR InterPro; IPR004575; MAT1/Tfb3.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR12683:SF13; PTHR12683:SF13; 1.
DR Pfam; PF06391; MAT1; 1.
DR Pfam; PF17121; zf-C3HC4_5; 1.
DR PIRSF; PIRSF003338; MAT1_metazoa; 1.
DR TIGRFAMs; TIGR00570; cdk7; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..318
FT /note="RNA polymerase II transcription factor B subunit 3"
FT /id="PRO_0000055936"
FT ZN_FING 10..55
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ SEQUENCE 318 AA; 37757 MW; F0EA9DAEEAA2E270 CRC64;
MDDDEKKDMC PICKTDRYLS PDMKFLVNPE CYHKICESCV DRIFSLGPAQ CPYEGCDKIL
RKNKFKTQIF ADVDVEREVD IRKRVFNVFN KTIEDFDGDT AAYDQYLEEV EDIVYGLDNG
IDVAKNEEKL RTYEELNKQL ILANMERNKQ TLENFEQRQK FEKEIKLKKR QLEKQIEDEE
RANREWVKWE IVNQLTTSED AEQVIENVKK TVKLKKSSAR RKLEELNKVL RNNPYMTISN
GRMKKQEHVP FTPFNGDRDR HKRYVIDEES YHDPVVKELQ TKKEYIASGF RAEYVYNRVL
TEAFMGLGCI IQDELQPS
