ID   TFB3_CANGA              Reviewed;         330 AA.
AC   Q6FMP4; Q8TFL7;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=RNA polymerase II transcription factor B subunit 3;
DE   AltName: Full=RNA polymerase II transcription factor B 38 kDa subunit;
DE   AltName: Full=RNA polymerase II transcription factor B p38 subunit;
GN   Name=TFB3; OrderedLocusNames=CAGL0K06369g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 97-330.
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=12125055; DOI=10.1002/yea.890;
RA   Walsh D.W., Wolfe K.H., Butler G.;
RT   "Genomic differences between Candida glabrata and Saccharomyces cerevisiae
RT   around the MRPL28 and GCN3 loci.";
RL   Yeast 19:991-994(2002).
CC   -!- FUNCTION: Acts as component of the general transcription and DNA repair
CC       factor IIH (TFIIH or factor B), which is essential for both basal and
CC       activated transcription, and is involved in nucleotide excision repair
CC       (NER) of damaged DNA. TFIIH as CTD kinase activity and DNA-dependent
CC       ATPase activity, and is essential for polymerase II transcription (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR380957; CAG61461.1; -; Genomic_DNA.
DR   EMBL; AY083606; AAM08093.1; -; Genomic_DNA.
DR   RefSeq; XP_448500.1; XM_448500.1.
DR   AlphaFoldDB; Q6FMP4; -.
DR   SMR; Q6FMP4; -.
DR   STRING; 5478.XP_448500.1; -.
DR   EnsemblFungi; CAG61461; CAG61461; CAGL0K06369g.
DR   GeneID; 2890432; -.
DR   KEGG; cgr:CAGL0K06369g; -.
DR   CGD; CAL0134781; CAGL0K06369g.
DR   VEuPathDB; FungiDB:CAGL0K06369g; -.
DR   eggNOG; KOG3800; Eukaryota.
DR   HOGENOM; CLU_048466_1_1_1; -.
DR   InParanoid; Q6FMP4; -.
DR   OMA; PANCPVA; -.
DR   Proteomes; UP000002428; Chromosome K.
DR   GO; GO:0070985; C:transcription factor TFIIK complex; IEA:EnsemblFungi.
DR   GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IEA:EnsemblFungi.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:EnsemblFungi.
DR   GO; GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IEA:EnsemblFungi.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR015877; Cdk-activating_kinase_MAT1_cen.
DR   InterPro; IPR004575; MAT1/Tfb3.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR12683:SF13; PTHR12683:SF13; 1.
DR   Pfam; PF06391; MAT1; 1.
DR   Pfam; PF17121; zf-C3HC4_5; 1.
DR   PIRSF; PIRSF003338; MAT1_metazoa; 1.
DR   TIGRFAMs; TIGR00570; cdk7; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..330
FT                   /note="RNA polymerase II transcription factor B subunit 3"
FT                   /id="PRO_0000055937"
FT   ZN_FING         23..68
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ   SEQUENCE   330 AA;  38837 MW;  3C5FAFBF95365888 CRC64;
     MSSAVASKGM NQGSEFDDNK DMCPICKTDR YLSPDVRFLV NPECYHKICE SCVDRIFSLG
     PAPCPYKSCD KILRKNKFKT QIFDDVGVEK EVDIRKRVFN VFNKTLEDFD NDLEAYNKYL
     EEVEDIVYKL DNKIDVVETE EKLRTYEELN KQLIMNNMER SKKDLENFEQ RQQFEKEMRM
     KKRMLERQIE SEDKMNKEWA KREIVNRLAS STNADDVIEG VKNTVKLKKS SARRKLEEIN
     RVLQNNPYSS LMLSQGLSRK EDNVPFTPFN GDRDLDKRYT IDQESYDDPF IKDLENRKDY
     IASGFRSDFV YDRMLTEAFM GLGCVVAEEV