TFB3_DEBHA
ID TFB3_DEBHA Reviewed; 340 AA.
AC Q6BP96;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=RNA polymerase II transcription factor B subunit 3;
DE AltName: Full=RNA polymerase II transcription factor B 38 kDa subunit;
DE AltName: Full=RNA polymerase II transcription factor B p38 subunit;
GN Name=TFB3; OrderedLocusNames=DEHA2E15378g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Acts as component of the general transcription and DNA repair
CC factor IIH (TFIIH or factor B), which is essential for both basal and
CC activated transcription, and is involved in nucleotide excision repair
CC (NER) of damaged DNA. TFIIH as CTD kinase activity and DNA-dependent
CC ATPase activity, and is essential for polymerase II transcription (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; CR382137; CAG88223.2; -; Genomic_DNA.
DR RefSeq; XP_459974.2; XM_459974.2.
DR AlphaFoldDB; Q6BP96; -.
DR SMR; Q6BP96; -.
DR STRING; 4959.XP_459974.2; -.
DR PRIDE; Q6BP96; -.
DR EnsemblFungi; CAG88223; CAG88223; DEHA2E15378g.
DR GeneID; 2902807; -.
DR KEGG; dha:DEHA2E15378g; -.
DR VEuPathDB; FungiDB:DEHA2E15378g; -.
DR eggNOG; KOG3800; Eukaryota.
DR HOGENOM; CLU_048466_1_1_1; -.
DR InParanoid; Q6BP96; -.
DR OMA; PANCPVA; -.
DR OrthoDB; 1454155at2759; -.
DR Proteomes; UP000000599; Chromosome E.
DR GO; GO:0005675; C:transcription factor TFIIH holo complex; IEA:InterPro.
DR GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR015877; Cdk-activating_kinase_MAT1_cen.
DR InterPro; IPR004575; MAT1/Tfb3.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR12683:SF13; PTHR12683:SF13; 1.
DR Pfam; PF06391; MAT1; 1.
DR Pfam; PF17121; zf-C3HC4_5; 1.
DR TIGRFAMs; TIGR00570; cdk7; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..340
FT /note="RNA polymerase II transcription factor B subunit 3"
FT /id="PRO_0000055938"
FT ZN_FING 12..57
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT COILED 124..206
FT /evidence="ECO:0000255"
SQ SEQUENCE 340 AA; 39717 MW; 78FC311611AE1CA8 CRC64;
MVVEDDRSKD MCPICKTDKY LSPNMNFLIN PECYHKICES CVDRIFSLGP APCPYPKCGK
ILRKNKFKKQ IFDDLGIEKE IDIRKRVSGI YNKTEEDFDD LKDYNKYLES VENIIFNLNN
GIDIEETESN LVKYENEHKI EILEKNMRES QKNSDLAKYQ EAMARLKQEK VKIQKQMEIE
DLEFQKQQKQ ELLDKLSTAQ SANSEELITQ SNNNILKRSS LRKRQLQQLT SQLDQQFQSS
NPFSKQAKAI EDEDNRTPFT PFKGDRELHK NYTFLPDIHK NDAMDVDEDA GLNTYHAPYL
SKLAKDKQYL GAGWRLNNAF ERALDEAFTG LCCFIDKEKT
