ID   TFB3_KLULA              Reviewed;         318 AA.
AC   Q6CT73;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=RNA polymerase II transcription factor B subunit 3;
DE   AltName: Full=RNA polymerase II transcription factor B 38 kDa subunit;
DE   AltName: Full=RNA polymerase II transcription factor B p38 subunit;
GN   Name=TFB3; OrderedLocusNames=KLLA0C14872g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as component of the general transcription and DNA repair
CC       factor IIH (TFIIH or factor B), which is essential for both basal and
CC       activated transcription, and is involved in nucleotide excision repair
CC       (NER) of damaged DNA. TFIIH as CTD kinase activity and DNA-dependent
CC       ATPase activity, and is essential for polymerase II transcription (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR382123; CAH01717.1; -; Genomic_DNA.
DR   RefSeq; XP_452866.1; XM_452866.1.
DR   AlphaFoldDB; Q6CT73; -.
DR   SMR; Q6CT73; -.
DR   STRING; 28985.XP_452866.1; -.
DR   EnsemblFungi; CAH01717; CAH01717; KLLA0_C14872g.
DR   GeneID; 2891973; -.
DR   KEGG; kla:KLLA0_C14872g; -.
DR   eggNOG; KOG3800; Eukaryota.
DR   HOGENOM; CLU_048466_1_1_1; -.
DR   InParanoid; Q6CT73; -.
DR   OMA; PANCPVA; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0070985; C:transcription factor TFIIK complex; IEA:EnsemblFungi.
DR   GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IEA:EnsemblFungi.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:EnsemblFungi.
DR   GO; GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IEA:EnsemblFungi.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR015877; Cdk-activating_kinase_MAT1_cen.
DR   InterPro; IPR004575; MAT1/Tfb3.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR12683:SF13; PTHR12683:SF13; 1.
DR   Pfam; PF06391; MAT1; 1.
DR   Pfam; PF17121; zf-C3HC4_5; 1.
DR   PIRSF; PIRSF003338; MAT1_metazoa; 1.
DR   TIGRFAMs; TIGR00570; cdk7; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..318
FT                   /note="RNA polymerase II transcription factor B subunit 3"
FT                   /id="PRO_0000055939"
FT   ZN_FING         10..55
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ   SEQUENCE   318 AA;  38071 MW;  B372378FE8344E92 CRC64;
     MDEDEKKDMC PICKTDRYLS PDMKFLINPE CYHKICESCV DRIFSLGPAQ CPYEGCDKIL
     RRNKFKTQIF DDVGVEKEVD IRKRVFNVFN KTLEDFDNNQ DDYDKYLEEV EDIIYNLDHG
     IDMEKTEERL RTYEELNKQL IMANLERSKQ DVANFEQRQK FEKEMKLKKR LLEKQIEEEE
     RANREWAKRE IVNQLTVNED AEEVIENVKK TVKLKKSSAR RKLEELNKVL RNNPYMTMTN
     GRMKKKDTVP FTPFNGDRDL HKRYELVENE YNDSFIRDLQ KKKEYIASGF RADFIYDRML
     TEAFMGLGCI ISEELQSS