ID   TFB3_YARLI              Reviewed;         346 AA.
AC   Q6C7D0;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=RNA polymerase II transcription factor B subunit 3;
DE   AltName: Full=RNA polymerase II transcription factor B 38 kDa subunit;
DE   AltName: Full=RNA polymerase II transcription factor B p38 subunit;
GN   Name=TFB3; OrderedLocusNames=YALI0E01826g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as component of the general transcription and DNA repair
CC       factor IIH (TFIIH or factor B), which is essential for both basal and
CC       activated transcription, and is involved in nucleotide excision repair
CC       (NER) of damaged DNA. TFIIH as CTD kinase activity and DNA-dependent
CC       ATPase activity, and is essential for polymerase II transcription (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR382131; CAG79011.1; -; Genomic_DNA.
DR   RefSeq; XP_503432.1; XM_503432.1.
DR   AlphaFoldDB; Q6C7D0; -.
DR   SMR; Q6C7D0; -.
DR   STRING; 4952.CAG79011; -.
DR   PRIDE; Q6C7D0; -.
DR   EnsemblFungi; CAG79011; CAG79011; YALI0_E01826g.
DR   GeneID; 2912060; -.
DR   KEGG; yli:YALI0E01826g; -.
DR   VEuPathDB; FungiDB:YALI0_E01826g; -.
DR   HOGENOM; CLU_048466_1_0_1; -.
DR   InParanoid; Q6C7D0; -.
DR   OMA; PANCPVA; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0005675; C:transcription factor TFIIH holo complex; IBA:GO_Central.
DR   GO; GO:0070985; C:transcription factor TFIIK complex; IEA:EnsemblFungi.
DR   GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IEA:EnsemblFungi.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR015877; Cdk-activating_kinase_MAT1_cen.
DR   InterPro; IPR004575; MAT1/Tfb3.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR12683:SF13; PTHR12683:SF13; 1.
DR   Pfam; PF06391; MAT1; 1.
DR   Pfam; PF17121; zf-C3HC4_5; 1.
DR   TIGRFAMs; TIGR00570; cdk7; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..346
FT                   /note="RNA polymerase II transcription factor B subunit 3"
FT                   /id="PRO_0000055941"
FT   ZN_FING         8..53
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          314..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   346 AA;  39676 MW;  BA58BF713E75F992 CRC64;
     MSEDGDICPI CKSSRYLNPD MKFLVNPQCY HKMCESCVDR LFAYGPVTCP HNGCEKILRK
     NKFKTQIFED VAVEKEVDVR QRVMSVMNKR EDEFDTLNDY NAYLEKIEDS IFTLLNGTAD
     EKDALTKEIE AYEKEHKAEI IANNKLRDEE DKYEQQKEDW MKEQRKANYL MAVEEQRAAQ
     EDKEAAKREL VHQLATSNKD ASSIEQNVQK TALKRSSART VNFQPMPTSR YFEKVKKESS
     KPETPFTPFN GDRQIPALFE VQDHYDDKVI EPLAHDIQHQ AGGFTLKAAY ARILQQAFFG
     LGVDVQTELL AEENGNSNGT AVPVKTEEDP VKLEEPSIQV KVESTV