ID   TFB4_CANGA              Reviewed;         335 AA.
AC   Q6FWA7;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=General transcription and DNA repair factor IIH subunit TFB4;
DE            Short=TFIIH subunit TFB4;
DE   AltName: Full=RNA polymerase II transcription factor B subunit 4;
GN   Name=TFB4; OrderedLocusNames=CAGL0D01650g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the general transcription and DNA repair factor
CC       IIH (TFIIH) core complex, which is involved in general and
CC       transcription-coupled nucleotide excision repair (NER) of damaged DNA
CC       and, when complexed to TFIIK, in RNA transcription by RNA polymerase
CC       II. In NER, TFIIH acts by opening DNA around the lesion to allow the
CC       excision of the damaged oligonucleotide and its replacement by a new
CC       DNA fragment. In transcription, TFIIH has an essential role in
CC       transcription initiation. When the pre-initiation complex (PIC) has
CC       been established, TFIIH is required for promoter opening and promoter
CC       escape. Phosphorylation of the C-terminal tail (CTD) of the largest
CC       subunit of RNA polymerase II by the kinase module TFIIK controls the
CC       initiation of transcription. {ECO:0000250|UniProtKB:Q12004}.
CC   -!- SUBUNIT: Component of the 7-subunit TFIIH core complex composed of
CC       XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in
CC       NER. The core complex associates with the 3-subunit CTD-kinase module
CC       TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit
CC       holoenzyme (holo-TFIIH) active in transcription.
CC       {ECO:0000250|UniProtKB:Q12004}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFB4 family. {ECO:0000305}.
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DR   EMBL; CR380950; CAG58398.1; -; Genomic_DNA.
DR   RefSeq; XP_445487.1; XM_445487.1.
DR   AlphaFoldDB; Q6FWA7; -.
DR   SMR; Q6FWA7; -.
DR   STRING; 5478.XP_445487.1; -.
DR   EnsemblFungi; CAG58398; CAG58398; CAGL0D01650g.
DR   GeneID; 2887225; -.
DR   KEGG; cgr:CAGL0D01650g; -.
DR   CGD; CAL0128459; CAGL0D01650g.
DR   VEuPathDB; FungiDB:CAGL0D01650g; -.
DR   eggNOG; KOG2487; Eukaryota.
DR   HOGENOM; CLU_040211_0_0_1; -.
DR   InParanoid; Q6FWA7; -.
DR   OMA; CFCHRKV; -.
DR   Proteomes; UP000002428; Chromosome D.
DR   GO; GO:0000112; C:nucleotide-excision repair factor 3 complex; IEA:EnsemblFungi.
DR   GO; GO:0000439; C:transcription factor TFIIH core complex; IEA:EnsemblFungi.
DR   GO; GO:0005675; C:transcription factor TFIIH holo complex; IEA:EnsemblFungi.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:EnsemblFungi.
DR   GO; GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IEA:EnsemblFungi.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR004600; TFIIH_Tfb4/GTF2H3.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR12831; PTHR12831; 1.
DR   Pfam; PF03850; Tfb4; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..335
FT                   /note="General transcription and DNA repair factor IIH
FT                   subunit TFB4"
FT                   /id="PRO_0000119270"
FT   ZN_FING         286..305
FT                   /note="C4-type"
SQ   SEQUENCE   335 AA;  37342 MW;  3C07A8E3F26D2149 CRC64;
     MDAIADPNFQ QTKLRSTATE DIPSLLTVVL DISPRLWAEF DHRSGEKQSV TTVLKSLIVF
     LNSHLAFNSA NQVAVIAAFS QGIQYLYPRS SDTSEQNAGN SKDLSIISSH MYRRFRNVDE
     TLIEEFYKLY QREESLIDKP VQKSTLSGAM AAALTYTNRL TKEFESISLR SRLLVITCGS
     SREKDEIFQY IPIMNCIFSA TKLKCPIDVI KIGGNKQSTF LQQTTDATNG VYIHLESTNG
     IIQYLSTAMS IDPSLRQIIV RPTQGSVDFR TSCYLTGKVV AIGYICSVCL CVLSIIPPGN
     KCPACDSQFD ERVIAKLKKK PVVPKSTLKK VKKKV