TFB4_DEBHA
ID TFB4_DEBHA Reviewed; 387 AA.
AC Q6BL86;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=General transcription and DNA repair factor IIH subunit TFB4;
DE Short=TFIIH subunit TFB4;
DE AltName: Full=RNA polymerase II transcription factor B subunit 4;
GN Name=TFB4; OrderedLocusNames=DEHA2F15510g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the general transcription and DNA repair factor
CC IIH (TFIIH) core complex, which is involved in general and
CC transcription-coupled nucleotide excision repair (NER) of damaged DNA
CC and, when complexed to TFIIK, in RNA transcription by RNA polymerase
CC II. In NER, TFIIH acts by opening DNA around the lesion to allow the
CC excision of the damaged oligonucleotide and its replacement by a new
CC DNA fragment. In transcription, TFIIH has an essential role in
CC transcription initiation. When the pre-initiation complex (PIC) has
CC been established, TFIIH is required for promoter opening and promoter
CC escape. Phosphorylation of the C-terminal tail (CTD) of the largest
CC subunit of RNA polymerase II by the kinase module TFIIK controls the
CC initiation of transcription. {ECO:0000250|UniProtKB:Q12004}.
CC -!- SUBUNIT: Component of the 7-subunit TFIIH core complex composed of
CC XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in
CC NER. The core complex associates with the 3-subunit CTD-kinase module
CC TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit
CC holoenzyme (holo-TFIIH) active in transcription.
CC {ECO:0000250|UniProtKB:Q12004}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TFB4 family. {ECO:0000305}.
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DR EMBL; CR382138; CAG89405.2; -; Genomic_DNA.
DR RefSeq; XP_461035.2; XM_461035.1.
DR AlphaFoldDB; Q6BL86; -.
DR SMR; Q6BL86; -.
DR STRING; 4959.XP_461035.2; -.
DR EnsemblFungi; CAG89405; CAG89405; DEHA2F15510g.
DR GeneID; 2904162; -.
DR KEGG; dha:DEHA2F15510g; -.
DR eggNOG; KOG2487; Eukaryota.
DR HOGENOM; CLU_040211_0_0_1; -.
DR InParanoid; Q6BL86; -.
DR OMA; CFCHRKV; -.
DR OrthoDB; 1220881at2759; -.
DR Proteomes; UP000000599; Chromosome F.
DR GO; GO:0000439; C:transcription factor TFIIH core complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR004600; TFIIH_Tfb4/GTF2H3.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12831; PTHR12831; 1.
DR Pfam; PF03850; Tfb4; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..387
FT /note="General transcription and DNA repair factor IIH
FT subunit TFB4"
FT /id="PRO_0000119271"
FT ZN_FING 327..346
FT /note="C4-type"
FT REGION 89..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 41795 MW; 62305248EA646F3A CRC64;
MDAIADSVFT DIGSSDSPSD DPSLLTVVLD VTPQSWYKIR NQITIQEVAK SLLVFLNAHL
SLNNSNQVAF IASTPQGSKF LYPNPEKNYD EVSSKKNGEG SNLNKADSTS SLVGDGMYRQ
FRIVDEAVLE KLNEIFADIS QNVDKSRSNS TLSGALSLAL TYTNRMLNLD SSISTTTASA
INTTTNANSN KTSSSGTTSN SMSTGGTNTT SLTSMRSRIL IVSSNDDNDI KYIPIMNTTF
AAQKMKVPID VAKLGERDSS YLQQASDATN GVYLHIANPE GLIQTLSTAF FIEPSIRSLI
ILPTNSNVNY RASCFITGKS VNLGFVCSVC LCIMSIIPKE GKCPTCGSKF DEKILAQLRR
GVVIPVKKKR KLDSNGNGQS DNVTPEI
