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TFB4_YARLI
ID   TFB4_YARLI              Reviewed;         340 AA.
AC   Q6CD24;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=General transcription and DNA repair factor IIH subunit TFB4;
DE            Short=TFIIH subunit TFB4;
DE   AltName: Full=RNA polymerase II transcription factor B subunit 4;
GN   Name=TFB4; OrderedLocusNames=YALI0C04367g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the general transcription and DNA repair factor
CC       IIH (TFIIH) core complex, which is involved in general and
CC       transcription-coupled nucleotide excision repair (NER) of damaged DNA
CC       and, when complexed to TFIIK, in RNA transcription by RNA polymerase
CC       II. In NER, TFIIH acts by opening DNA around the lesion to allow the
CC       excision of the damaged oligonucleotide and its replacement by a new
CC       DNA fragment. In transcription, TFIIH has an essential role in
CC       transcription initiation. When the pre-initiation complex (PIC) has
CC       been established, TFIIH is required for promoter opening and promoter
CC       escape. Phosphorylation of the C-terminal tail (CTD) of the largest
CC       subunit of RNA polymerase II by the kinase module TFIIK controls the
CC       initiation of transcription. {ECO:0000250|UniProtKB:Q12004}.
CC   -!- SUBUNIT: Component of the 7-subunit TFIIH core complex composed of
CC       XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in
CC       NER. The core complex associates with the 3-subunit CTD-kinase module
CC       TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit
CC       holoenzyme (holo-TFIIH) active in transcription.
CC       {ECO:0000250|UniProtKB:Q12004}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFB4 family. {ECO:0000305}.
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DR   EMBL; CR382129; CAG81737.1; -; Genomic_DNA.
DR   RefSeq; XP_501438.1; XM_501438.1.
DR   AlphaFoldDB; Q6CD24; -.
DR   SMR; Q6CD24; -.
DR   STRING; 4952.CAG81737; -.
DR   EnsemblFungi; CAG81737; CAG81737; YALI0_C04367g.
DR   GeneID; 2909399; -.
DR   KEGG; yli:YALI0C04367g; -.
DR   VEuPathDB; FungiDB:YALI0_C04367g; -.
DR   HOGENOM; CLU_040211_0_0_1; -.
DR   InParanoid; Q6CD24; -.
DR   OMA; CFCHRKV; -.
DR   Proteomes; UP000001300; Chromosome C.
DR   GO; GO:0000112; C:nucleotide-excision repair factor 3 complex; IEA:EnsemblFungi.
DR   GO; GO:0000439; C:transcription factor TFIIH core complex; IBA:GO_Central.
DR   GO; GO:0005675; C:transcription factor TFIIH holo complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006289; P:nucleotide-excision repair; IBA:GO_Central.
DR   GO; GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IBA:GO_Central.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR004600; TFIIH_Tfb4/GTF2H3.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR12831; PTHR12831; 1.
DR   Pfam; PF03850; Tfb4; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..340
FT                   /note="General transcription and DNA repair factor IIH
FT                   subunit TFB4"
FT                   /id="PRO_0000119274"
FT   ZN_FING         294..313
FT                   /note="C4-type"
FT   REGION          85..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..117
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   340 AA;  37795 MW;  FDC8204E920ED9DF CRC64;
     MNAIDGTSRQ LKDTEDQTLD DTPSLLSIII DAHVPSWEEI KSQISISEAV ASILVFINAH
     LALHNSNSVN VIGYNASGAR ILYPPKSGVE STRSKEREER SESVSDGEQA PSKKDHSMYR
     QFKTVDEVVQ TELWNMLNHT NYVEEEKQHN SAISGALSLA LGFINKHVFV DESRMRARIL
     LLTVGHKNET IQYIPTMNCI FAAQKLKIPV DVCKLGPGSD QVFLQQACDS THGIYMDISE
     KNSKTPKGLV QYLLSGFISD PSLRPHIVLP TQSNVDFRAA CFLTKQVVDI GYVCSVCLCI
     MSQIPSNRRC PTCDTTYSEK TLAGLGRKPL KKKKKKVVKP
 
 
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