TFB5_ARATH
ID TFB5_ARATH Reviewed; 71 AA.
AC Q6NNM0; Q9LNA6;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=General transcription and DNA repair factor IIH subunit TFB5;
DE Short=AtTFB5 {ECO:0000303|PubMed:15645454};
DE Short=TFIIH subunit TFB5;
DE AltName: Full=RNA polymerase II transcription factor B subunit 5;
GN Name=TFB5 {ECO:0000305}; Synonyms=GTF2H5 {ECO:0000305};
GN OrderedLocusNames=At1g12400 {ECO:0000312|Araport:AT1G12400};
GN ORFNames=F5O11.12 {ECO:0000312|EMBL:AAF79634.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAR92302.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP COMPONENT OF TFIIH CORE COMPLEX, AND NOMENCLATURE.
RX PubMed=15645454; DOI=10.1002/em.20094;
RA Kunz B.A., Anderson H.J., Osmond M.J., Vonarx E.J.;
RT "Components of nucleotide excision repair and DNA damage tolerance in
RT Arabidopsis thaliana.";
RL Environ. Mol. Mutagen. 45:115-127(2005).
CC -!- FUNCTION: Component of the general transcription and DNA repair factor
CC IIH (TFIIH) core complex, which is involved in general and
CC transcription-coupled nucleotide excision repair (NER) of damaged DNA
CC and, when complexed to CAK, in RNA transcription by RNA polymerase II.
CC In NER, TFIIH acts by opening DNA around the lesion to allow the
CC excision of the damaged oligonucleotide and its replacement by a new
CC DNA fragment. In transcription, TFIIH has an essential role in
CC transcription initiation. When the pre-initiation complex (PIC) has
CC been established, TFIIH is required for promoter opening and promoter
CC escape. Phosphorylation of the C-terminal tail (CTD) of the largest
CC subunit of RNA polymerase II by the kinase module CAK controls the
CC initiation of transcription. {ECO:0000250|UniProtKB:Q6ZYL4}.
CC -!- SUBUNIT: Component of the 7-subunit TFIIH core complex composed of XPB,
CC XPD, TFB1/GTF2H1, GTF2H2/P44, TFB4/GTF2H3, TFB2/GTF2H4 and TFB5/GTF2H5,
CC which is active in NER. The core complex associates with the 3-subunit
CC CDK-activating kinase (CAK) module composed of CYCH1/cyclin H1, CDKD
CC and MAT1/At4g30820 to form the 10-subunit holoenzyme (holo-TFIIH)
CC active in transcription. {ECO:0000250|UniProtKB:Q6ZYL4,
CC ECO:0000305|PubMed:15645454}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TFB5 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79634.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC025416; AAF79634.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28875.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59075.1; -; Genomic_DNA.
DR EMBL; BT010796; AAR24163.1; -; mRNA.
DR EMBL; BT011266; AAR92302.1; -; mRNA.
DR PIR; E86258; E86258.
DR RefSeq; NP_001321468.1; NM_001332033.1.
DR RefSeq; NP_172702.1; NM_101112.3.
DR AlphaFoldDB; Q6NNM0; -.
DR SMR; Q6NNM0; -.
DR STRING; 3702.AT1G12400.1; -.
DR PaxDb; Q6NNM0; -.
DR PRIDE; Q6NNM0; -.
DR ProteomicsDB; 246398; -.
DR EnsemblPlants; AT1G12400.1; AT1G12400.1; AT1G12400.
DR EnsemblPlants; AT1G12400.2; AT1G12400.2; AT1G12400.
DR GeneID; 837795; -.
DR Gramene; AT1G12400.1; AT1G12400.1; AT1G12400.
DR Gramene; AT1G12400.2; AT1G12400.2; AT1G12400.
DR KEGG; ath:AT1G12400; -.
DR Araport; AT1G12400; -.
DR TAIR; locus:2034685; AT1G12400.
DR eggNOG; KOG3451; Eukaryota.
DR HOGENOM; CLU_166246_4_1_1; -.
DR InParanoid; Q6NNM0; -.
DR OMA; IMENMNP; -.
DR PRO; PR:Q6NNM0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q6NNM0; baseline and differential.
DR GO; GO:0000439; C:transcription factor TFIIH core complex; IBA:GO_Central.
DR GO; GO:0005675; C:transcription factor TFIIH holo complex; IBA:GO_Central.
DR GO; GO:0006294; P:nucleotide-excision repair, preincision complex assembly; IBA:GO_Central.
DR GO; GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IBA:GO_Central.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro.
DR Gene3D; 3.30.70.1220; -; 1.
DR InterPro; IPR035935; TFB5-like_sf.
DR InterPro; IPR009400; TFIIH_TTDA/Tfb5.
DR PANTHER; PTHR28580; PTHR28580; 1.
DR Pfam; PF06331; Tfb5; 1.
DR SMART; SM01395; Tbf5; 1.
DR SUPFAM; SSF142897; SSF142897; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..71
FT /note="General transcription and DNA repair factor IIH
FT subunit TFB5"
FT /id="PRO_0000435437"
SQ SEQUENCE 71 AA; 8111 MW; B3DC7DD6DC0C3C42 CRC64;
MVNAIKGVFV SCDIPMTQFI VNMNNSMPPS QKFIIHVLDS THLFVQPHVE QMIRSAISDF
RDQNSYEKPT S
