ID   TFB5_DEBHA              Reviewed;          69 AA.
AC   Q6BVH4;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=General transcription and DNA repair factor IIH subunit TFB5;
DE            Short=TFIIH subunit TFB5;
DE   AltName: Full=RNA polymerase II transcription factor B subunit 5;
GN   Name=TFB5; OrderedLocusNames=DEHA2C02662g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the general transcription and DNA repair factor
CC       IIH (TFIIH) core complex, which is involved in general and
CC       transcription-coupled nucleotide excision repair (NER) of damaged DNA
CC       and, when complexed to TFIIK, in RNA transcription by RNA polymerase
CC       II. In NER, TFIIH acts by opening DNA around the lesion to allow the
CC       excision of the damaged oligonucleotide and its replacement by a new
CC       DNA fragment. In transcription, TFIIH has an essential role in
CC       transcription initiation. When the pre-initiation complex (PIC) has
CC       been established, TFIIH is required for promoter opening and promoter
CC       escape. Phosphorylation of the C-terminal tail (CTD) of the largest
CC       subunit of RNA polymerase II by the kinase module TFIIK controls the
CC       initiation of transcription. {ECO:0000250|UniProtKB:Q3E7C1}.
CC   -!- SUBUNIT: Component of the 7-subunit TFIIH core complex composed of
CC       XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in
CC       NER. The core complex associates with the 3-subunit CTD-kinase module
CC       TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit
CC       holoenzyme (holo-TFIIH) active in transcription.
CC       {ECO:0000250|UniProtKB:Q3E7C1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TFB5 family. {ECO:0000305}.
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DR   EMBL; CR382135; CAG85835.2; -; Genomic_DNA.
DR   RefSeq; XP_457795.2; XM_457795.1.
DR   AlphaFoldDB; Q6BVH4; -.
DR   SMR; Q6BVH4; -.
DR   STRING; 4959.XP_457795.2; -.
DR   EnsemblFungi; CAG85835; CAG85835; DEHA2C02662g.
DR   GeneID; 2900788; -.
DR   KEGG; dha:DEHA2C02662g; -.
DR   VEuPathDB; FungiDB:DEHA2C02662g; -.
DR   eggNOG; KOG3451; Eukaryota.
DR   HOGENOM; CLU_166246_3_2_1; -.
DR   InParanoid; Q6BVH4; -.
DR   OMA; KVMQPEE; -.
DR   OrthoDB; 1591321at2759; -.
DR   Proteomes; UP000000599; Chromosome C.
DR   GO; GO:0000439; C:transcription factor TFIIH core complex; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:InterPro.
DR   Gene3D; 3.30.70.1220; -; 1.
DR   InterPro; IPR035935; TFB5-like_sf.
DR   InterPro; IPR009400; TFIIH_TTDA/Tfb5.
DR   PANTHER; PTHR28580; PTHR28580; 1.
DR   Pfam; PF06331; Tfb5; 1.
DR   SMART; SM01395; Tbf5; 1.
DR   SUPFAM; SSF142897; SSF142897; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..69
FT                   /note="General transcription and DNA repair factor IIH
FT                   subunit TFB5"
FT                   /id="PRO_0000119280"
SQ   SEQUENCE   69 AA;  7860 MW;  D47E4F1C6C980101 CRC64;
     MPSAIKGVMV QCDPSIKALI LKIDSERHDI VIEELDETHL VIDSNKVQAV KNELNRLLSK
     NIYNPFDEQ