TFC5_SCHPO
ID TFC5_SCHPO Reviewed; 520 AA.
AC O94481;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2012, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Transcription factor TFIIIB component B'' {ECO:0000250|UniProtKB:P46678};
DE AltName: Full=Transcription factor TFIIIB complex subunit bdp1;
GN Name=bdp1; Synonyms=tfc5 {ECO:0000250|UniProtKB:P46678};
GN ORFNames=SPCC1919.14c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: General activator of RNA polymerase III transcription.
CC {ECO:0000250|UniProtKB:P46678}.
CC -!- SUBUNIT: TFIIIB comprises the TATA-binding protein (tbp1), the B-
CC related factor (brf1) and the B'' component (bdp1).
CC {ECO:0000250|UniProtKB:P46678}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624,
CC ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the TFC5 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA22645.2; -; Genomic_DNA.
DR PIR; T41239; T41239.
DR RefSeq; NP_588496.2; NM_001023486.2.
DR AlphaFoldDB; O94481; -.
DR SMR; O94481; -.
DR BioGRID; 275486; 2.
DR STRING; 4896.SPCC1919.14c.1; -.
DR iPTMnet; O94481; -.
DR MaxQB; O94481; -.
DR PaxDb; O94481; -.
DR PRIDE; O94481; -.
DR EnsemblFungi; SPCC1919.14c.1; SPCC1919.14c.1:pep; SPCC1919.14c.
DR GeneID; 2538909; -.
DR KEGG; spo:SPCC1919.14c; -.
DR PomBase; SPCC1919.14c; bdp1.
DR VEuPathDB; FungiDB:SPCC1919.14c; -.
DR eggNOG; KOG2009; Eukaryota.
DR HOGENOM; CLU_537651_0_0_1; -.
DR InParanoid; O94481; -.
DR OMA; SATWGNR; -.
DR Reactome; R-SPO-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-SPO-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR PRO; PR:O94481; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000126; C:transcription factor TFIIIB complex; ISS:PomBase.
DR GO; GO:0003677; F:DNA binding; ISM:PomBase.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; IC:PomBase.
DR GO; GO:0001156; F:TFIIIC-class transcription factor complex binding; IBA:GO_Central.
DR GO; GO:0070898; P:RNA polymerase III preinitiation complex assembly; IBA:GO_Central.
DR CDD; cd00167; SANT; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR039467; TFIIIB_B''_Myb.
DR Pfam; PF15963; Myb_DNA-bind_7; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51293; SANT; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..520
FT /note="Transcription factor TFIIIB component B''"
FT /id="PRO_0000361656"
FT DOMAIN 376..427
FT /note="SANT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT REGION 1..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 520 AA; 59083 MW; 4BAD4FB5EBFAF51F CRC64;
MSSQILTSPT KKSMSRFAPK FTARREKVSD QKEVVHEEKN QPLTGNEVET SAQLSRDTAN
ADISSPVVQT VVHKEATENP TASSYRKDDS VKQNEKLLHS NPTFKISKPT VLEQPLNAIE
HLSPETDLSS SAEQQFMKEL DLFFDENIPL SQLSAVSDGK ADSPATKKSR RSYRESSLKR
KSQLILENVG TDEKIINISE TKMSALCDDP GIGRKSQRFI ELEKMLFEEK RAKRIKKQGA
STASSSREAS LDSTIKQPLS ASLLESSEPK EKEEIVGSLE EEGTDESASL EDSLSHPTKS
ILDQLADKME VDGLNNNSNY SATPRTRVVN GQIVLDETSL EVDRHERDFV PAEEREYVEE
NSLSRRVTSA TWGNRQKPEK WNAMDTEKFY KALSQWGTDF ALIANMFPTR NRRQIKLKFK
QEERRNPARV NQALKIKKPI DMEEYSKVSG KVFRPVEEME KELQKIRENF EEERRRAIEV
AEQRQLIVNH ELEQEKNAPS PTDDKSYVFE DGVEVVGQVV
