ID   TFC7_DOTSN              Reviewed;         381 AA.
AC   M2XJV1;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2013, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Hps1-dma1 cluster transcription factor tfc7 {ECO:0000303|PubMed:31053329};
GN   Name=tfc7; ORFNames=DOTSEDRAFT_83206;
OS   Dothistroma septosporum (strain NZE10 / CBS 128990) (Red band needle blight
OS   fungus) (Mycosphaerella pini).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Dothistroma.
OX   NCBI_TaxID=675120;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NZE10 / CBS 128990;
RX   PubMed=23209441; DOI=10.1371/journal.pgen.1003088;
RA   de Wit P.J.G.M., van der Burgt A., Oekmen B., Stergiopoulos I.,
RA   Abd-Elsalam K.A., Aerts A.L., Bahkali A.H., Beenen H.G., Chettri P.,
RA   Cox M.P., Datema E., de Vries R.P., Dhillon B., Ganley A.R.,
RA   Griffiths S.A., Guo Y., Hamelin R.C., Henrissat B., Kabir M.S.,
RA   Jashni M.K., Kema G., Klaubauf S., Lapidus A., Levasseur A., Lindquist E.,
RA   Mehrabi R., Ohm R.A., Owen T.J., Salamov A., Schwelm A., Schijlen E.,
RA   Sun H., van den Burg H.A., van Ham R.C.H.J., Zhang S., Goodwin S.B.,
RA   Grigoriev I.V., Collemare J., Bradshaw R.E.;
RT   "The genomes of the fungal plant pathogens Cladosporium fulvum and
RT   Dothistroma septosporum reveal adaptation to different hosts and lifestyles
RT   but also signatures of common ancestry.";
RL   PLoS Genet. 8:E1003088-E1003088(2012).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NZE10 / CBS 128990;
RX   PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA   Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA   Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA   LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA   Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA   Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA   Grigoriev I.V.;
RT   "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT   genomes of eighteen Dothideomycetes fungi.";
RL   PLoS Pathog. 8:E1003037-E1003037(2012).
RN   [3]
RP   FUNCTION.
RX   PubMed=31053329; DOI=10.1016/j.funbio.2019.02.006;
RA   Ozturk I.K., Dupont P.Y., Chettri P., McDougal R., Boehl O.J., Cox R.J.,
RA   Bradshaw R.E.;
RT   "Evolutionary relics dominate the small number of secondary metabolism
RT   genes in the hemibiotrophic fungus Dothistroma septosporum.";
RL   Fungal Biol. 123:397-407(2019).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       hps1-dma1 gene cluster that probably mediates the biosynthesis a
CC       derivative of cyclopiazonic acid (CPA) (Probable). Further studies are
CC       required to whether the CPA-like hps1-dma1 cluster is functional or a
CC       non-functional relic reflecting evolution of D.septosporum (Probable).
CC       {ECO:0000305|PubMed:31053329}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; KB446545; EME39732.1; -; Genomic_DNA.
DR   AlphaFoldDB; M2XJV1; -.
DR   EnsemblFungi; EME39732; EME39732; DOTSEDRAFT_83206.
DR   eggNOG; ENOG502RJXM; Eukaryota.
DR   HOGENOM; CLU_035265_0_0_1; -.
DR   OMA; SECANIG; -.
DR   OrthoDB; 1396569at2759; -.
DR   Proteomes; UP000016933; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045122; P:aflatoxin biosynthetic process; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR013700; AflR.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF08493; AflR; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..381
FT                   /note="Hps1-dma1 cluster transcription factor tfc7"
FT                   /id="PRO_0000447728"
FT   DNA_BIND        10..37
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          41..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..88
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   381 AA;  41464 MW;  4F927B811FA7510B CRC64;
     MSTIKYRAAC DHCSATKIKC TQERPQCTRC RALGRDCHYS RSLRAGKPPR SSQGLNRKIS
     NAPVLPRQNT PVSNPTSMSS KPEHWPTMPT SYPTPQAAAP TAEIFHFPDL SSAATSSSSS
     PANTDWFFDF NSGSADGLGD LTPPLVVTAP HLPPLDHDLK HPVFPTQGIH FGAFADLISL
     PPASPLLPSP SLADGDRCAK LATETLNSLY DMPANHLHGS GNRHPSVDQT LSTCARAVQA
     IHELVNCSCQ KDLYLPMLII IVASKIVAWY QAVAYIRDPG TGFADGKQCF REVVVEGPLN
     IGAYQLDDEV GWTLKNQIVL GQLQRLNEAV NIYDRRYCSD SLGGQMTEGG KLYASMVGFV
     KSTLQFTIHA LEGRIRSGHP R