ID   TFCP2_CHICK             Reviewed;         496 AA.
AC   Q7T2U9;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Transcription factor CP2;
GN   Name=TFCP2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=15107494; DOI=10.1093/nar/gkh545;
RA   Acloque H., Mey A., Birot A.-M., Gruffat H., Pain B., Samarut J.;
RT   "Transcription factor cCP2 controls gene expression in chicken embryonic
RT   stem cells.";
RL   Nucleic Acids Res. 32:2259-2271(2004).
CC   -!- FUNCTION: Binds the B-response element 5'-CAAGTCCAGGCAAGT-3' of the
CC       ENS1/ERNI promoter. May be the major transcription activator thus being
CC       essential for its expression. {ECO:0000269|PubMed:15107494}.
CC   -!- SUBUNIT: Component of the SSP (stage selector protein) complex, which
CC       appears to be a heteromer of TFCP2 and 2 copies of NFE4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the epiblast at the pre-primitive
CC       streak stage. At the primitive streak stage, expressed in the extending
CC       primitive streak and in the prospective neural plate. At stages 7 and
CC       8, expressed in the neural folds, somites and in the regressing
CC       primitive streak. At stage 12, ubiquitously expressed in the whole
CC       embryo. {ECO:0000269|PubMed:15107494}.
CC   -!- SIMILARITY: Belongs to the grh/CP2 family. CP2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY298725; AAP56347.1; -; mRNA.
DR   RefSeq; NP_989715.1; NM_204384.1.
DR   AlphaFoldDB; Q7T2U9; -.
DR   SMR; Q7T2U9; -.
DR   STRING; 9031.ENSGALP00000003492; -.
DR   PaxDb; Q7T2U9; -.
DR   GeneID; 378900; -.
DR   KEGG; gga:378900; -.
DR   CTD; 7024; -.
DR   VEuPathDB; HostDB:geneid_378900; -.
DR   eggNOG; KOG4091; Eukaryota.
DR   HOGENOM; CLU_015127_2_0_1; -.
DR   InParanoid; Q7T2U9; -.
DR   PRO; PR:Q7T2U9; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR007604; CP2.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR041418; SAM_3.
DR   Pfam; PF04516; CP2; 1.
DR   Pfam; PF18016; SAM_3; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS51968; GRH_CP2_DB; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..496
FT                   /note="Transcription factor CP2"
FT                   /id="PRO_0000228003"
FT   DOMAIN          61..300
FT                   /note="Grh/CP2 DB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01313"
FT   REGION          133..386
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          238..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          296..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        239..267
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   496 AA;  56473 MW;  94C451AF30BD249B CRC64;
     MAWALKLPLA DEVIESGLVQ DFDASLSGIG QELGAGAYSM SDVLALPIFK QEESSLPPEN
     ENKILPFQYV LCAATSPAVK LHDETLTYLN QGQSYEIRML DNRKIGELPE INGKLVKSIF
     RVVFHDRRLQ YTEHQQLEGW RWNRPGDRIL DIDIPMSVGI IDPRANPTQL NTVEFLWDPS
     KRTSVFIQVH CISTEFTMRK HGGEKGVPFR VQIDTFKENE NGEYTEHLHS ASCQIKVFKP
     KGADRKQKTD REKMEKRTPH EKEKYQPSYE TTILTECSPW PEITYVNNAP SPGFNSSHSS
     FSIGEGNGSP NHQPEPPPPI ADNLLPTSTP QEAQQWLHRN RFSTFSRLFR NFSGADLLKL
     TREDVIQICG PADGIRLFNA LKGRMVRPRL TIYVCQESQQ LQELQQKHED GDAVTSTFFV
     YHAIYLEELT AVELTEKLAQ LFSISSQQIS QIYKQGPTGI HVLISDEMIQ NFQDESCFVL
     DTMKAETNDS YHIILK