BRD9_DANRE
ID BRD9_DANRE Reviewed; 631 AA.
AC Q7ZUF2;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Bromodomain-containing protein 9;
GN Name=brd9;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in chromatin remodeling and regulation of
CC transcription. Acts as a chromatin reader that recognizes and binds
CC acylated histones: binds histones that are acetylated and/or
CC butyrylated. {ECO:0000250|UniProtKB:Q9H8M2}.
CC -!- SUBUNIT: Binds acetylated histones H3 and H4. Binds butyrylated histone
CC H4. {ECO:0000250|UniProtKB:Q9H8M2}.
CC -!- DOMAIN: The Bromo domain mediates interaction with histones that have
CC acetylated lysine residues at specific positions. Also recognizes and
CC binds histones that are butyrylated. {ECO:0000250|UniProtKB:Q9H8M2}.
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DR EMBL; BC049140; AAH49140.1; -; mRNA.
DR RefSeq; NP_956569.1; NM_200275.1.
DR AlphaFoldDB; Q7ZUF2; -.
DR SMR; Q7ZUF2; -.
DR STRING; 7955.ENSDARP00000023970; -.
DR PaxDb; Q7ZUF2; -.
DR GeneID; 393245; -.
DR KEGG; dre:393245; -.
DR CTD; 65980; -.
DR ZFIN; ZDB-GENE-060502-1; brd9.
DR eggNOG; KOG1828; Eukaryota.
DR InParanoid; Q7ZUF2; -.
DR OrthoDB; 439339at2759; -.
DR PhylomeDB; Q7ZUF2; -.
DR PRO; PR:Q7ZUF2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0070577; F:lysine-acetylated histone binding; ISS:UniProtKB.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.20.920.10; -; 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR021900; DUF3512.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF12024; DUF3512; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; SSF47370; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 2: Evidence at transcript level;
KW Bromodomain; Chromatin regulator; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..631
FT /note="Bromodomain-containing protein 9"
FT /id="PRO_0000239221"
FT DOMAIN 183..253
FT /note="Bromo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 39..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..246
FT /note="Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu
FT binding"
FT /evidence="ECO:0000250|UniProtKB:Q9H8M2"
FT REGION 571..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 199
FT /note="Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu
FT binding"
FT /evidence="ECO:0000250|UniProtKB:Q9H8M2"
FT SITE 252
FT /note="Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu
FT binding"
FT /evidence="ECO:0000250|UniProtKB:Q9H8M2"
SQ SEQUENCE 631 AA; 71542 MW; 968BA39BB7C1BC9A CRC64;
MGKKHKKYRP EWRAVEGDYE DKPLEKPLKL VLKVGGSEVT ELSGSGHDSS YYDDRSDHEW
ERHKEKKKKK KKKSEKEKYA DDDERRRRKE EKKKKREREQ SETASTAPVE PFTLPKPVEV
VVEEKKRKRD KFESESEADE FHPAVKVEVE QPADRPVRAC RTQQENEATP HQQLLEHFLR
LLQRKDAHGF FAFPVTDAIA PGYSMIIKHP MDFSTMKDKI AANEYKTITE FKADFKLMCD
NAMVYNRPET VYYKAAKKLL HTGFKMMSKQ AAILGDDDIA PEEPVTEMMP IHTEYPKKSK
KQPVKEPIIS DMYELEGNAC SLTDSTAEEH VLALVEHAAD EARDRINRFM PNSKIGYLKK
DTEGSLMYVV VNQDPEGEEE ETHPVDLSSL ANKLIPGLTS LGFKDDRRHK VTFLSSAYNT
QTLQNNSIYP DLHPEEMDML YSAYGDETGV QCALSLQEFV KGCGGFTKRL VDDLLDKMTA
GDHSKAVVQI RQKRNLPIDE AKSSLCDMPG TDGGGMEAGS VLDFMSMKSY PDMSLDMLNT
LGKCVKKEPE HEDGHQHFDD PTKLLQEFQD ASVDRVGSRP SSNLSSLSNA SERDQHHLGS
SPHLGVGDQA EMVQDPYEFL QSPEPGSTAN S