ID   BRD9_DANRE              Reviewed;         631 AA.
AC   Q7ZUF2;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Bromodomain-containing protein 9;
GN   Name=brd9;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in chromatin remodeling and regulation of
CC       transcription. Acts as a chromatin reader that recognizes and binds
CC       acylated histones: binds histones that are acetylated and/or
CC       butyrylated. {ECO:0000250|UniProtKB:Q9H8M2}.
CC   -!- SUBUNIT: Binds acetylated histones H3 and H4. Binds butyrylated histone
CC       H4. {ECO:0000250|UniProtKB:Q9H8M2}.
CC   -!- DOMAIN: The Bromo domain mediates interaction with histones that have
CC       acetylated lysine residues at specific positions. Also recognizes and
CC       binds histones that are butyrylated. {ECO:0000250|UniProtKB:Q9H8M2}.
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DR   EMBL; BC049140; AAH49140.1; -; mRNA.
DR   RefSeq; NP_956569.1; NM_200275.1.
DR   AlphaFoldDB; Q7ZUF2; -.
DR   SMR; Q7ZUF2; -.
DR   STRING; 7955.ENSDARP00000023970; -.
DR   PaxDb; Q7ZUF2; -.
DR   GeneID; 393245; -.
DR   KEGG; dre:393245; -.
DR   CTD; 65980; -.
DR   ZFIN; ZDB-GENE-060502-1; brd9.
DR   eggNOG; KOG1828; Eukaryota.
DR   InParanoid; Q7ZUF2; -.
DR   OrthoDB; 439339at2759; -.
DR   PhylomeDB; Q7ZUF2; -.
DR   PRO; PR:Q7ZUF2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0070577; F:lysine-acetylated histone binding; ISS:UniProtKB.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.20.920.10; -; 1.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR021900; DUF3512.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF12024; DUF3512; 1.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00297; BROMO; 1.
DR   SUPFAM; SSF47370; SSF47370; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
PE   2: Evidence at transcript level;
KW   Bromodomain; Chromatin regulator; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..631
FT                   /note="Bromodomain-containing protein 9"
FT                   /id="PRO_0000239221"
FT   DOMAIN          183..253
FT                   /note="Bromo"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          39..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          244..246
FT                   /note="Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu
FT                   binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8M2"
FT   REGION          571..631
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..103
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        575..595
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            199
FT                   /note="Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu
FT                   binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8M2"
FT   SITE            252
FT                   /note="Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu
FT                   binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8M2"
SQ   SEQUENCE   631 AA;  71542 MW;  968BA39BB7C1BC9A CRC64;
     MGKKHKKYRP EWRAVEGDYE DKPLEKPLKL VLKVGGSEVT ELSGSGHDSS YYDDRSDHEW
     ERHKEKKKKK KKKSEKEKYA DDDERRRRKE EKKKKREREQ SETASTAPVE PFTLPKPVEV
     VVEEKKRKRD KFESESEADE FHPAVKVEVE QPADRPVRAC RTQQENEATP HQQLLEHFLR
     LLQRKDAHGF FAFPVTDAIA PGYSMIIKHP MDFSTMKDKI AANEYKTITE FKADFKLMCD
     NAMVYNRPET VYYKAAKKLL HTGFKMMSKQ AAILGDDDIA PEEPVTEMMP IHTEYPKKSK
     KQPVKEPIIS DMYELEGNAC SLTDSTAEEH VLALVEHAAD EARDRINRFM PNSKIGYLKK
     DTEGSLMYVV VNQDPEGEEE ETHPVDLSSL ANKLIPGLTS LGFKDDRRHK VTFLSSAYNT
     QTLQNNSIYP DLHPEEMDML YSAYGDETGV QCALSLQEFV KGCGGFTKRL VDDLLDKMTA
     GDHSKAVVQI RQKRNLPIDE AKSSLCDMPG TDGGGMEAGS VLDFMSMKSY PDMSLDMLNT
     LGKCVKKEPE HEDGHQHFDD PTKLLQEFQD ASVDRVGSRP SSNLSSLSNA SERDQHHLGS
     SPHLGVGDQA EMVQDPYEFL QSPEPGSTAN S