ID   TFCP2_XENLA             Reviewed;         506 AA.
AC   Q4V860;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Transcription factor CP2;
GN   Name=tfcp2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a transcription factor.
CC   -!- SUBUNIT: Component of the SSP (stage selector protein) complex, which
CC       appears to be a heteromer of TFCP2 and 2 copies of NFE4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the grh/CP2 family. CP2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC097529; AAH97529.1; -; mRNA.
DR   RefSeq; NP_001089447.1; NM_001095978.1.
DR   AlphaFoldDB; Q4V860; -.
DR   SMR; Q4V860; -.
DR   BioGRID; 592278; 2.
DR   DNASU; 734497; -.
DR   GeneID; 734497; -.
DR   KEGG; xla:734497; -.
DR   CTD; 734497; -.
DR   Xenbase; XB-GENE-865546; tfcp2.L.
DR   OMA; MILPFQY; -.
DR   OrthoDB; 386296at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 734497; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd09589; SAM_TFCP2; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR007604; CP2.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR041418; SAM_3.
DR   InterPro; IPR037599; TFCP2_SAM.
DR   Pfam; PF04516; CP2; 1.
DR   Pfam; PF18016; SAM_3; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS51968; GRH_CP2_DB; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..506
FT                   /note="Transcription factor CP2"
FT                   /id="PRO_0000228004"
FT   DOMAIN          61..300
FT                   /note="Grh/CP2 DB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01313"
FT   REGION          133..395
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          238..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          291..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        239..264
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..307
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   506 AA;  57542 MW;  A56E8A46FD2F3A5E CRC64;
     MAWALKLPLA DEVIESGLVQ DFDASLSGIG QELGAGAYSM SDVLALPIFK QEESSLPSEN
     ENKILPFQYV LCTATSPAVK LHEETLTYLN QGQSYEIRML DNRKIGELPE LNGKLVKSIF
     RVVFHDRRLQ YTEHQQLEGW RWNRPGDRIL DIDIPMSVGI IDPRANPTQL NTIEFLWDPA
     KRTSVFIQVH CISTEFTMRK HGGEKGVPFR VQIDTFKENE NGEYTEHLHS ASSQIKVFKP
     KGADRKQKTD REKMEKRTPQ EKEKYQPSYE TTILTECSPW PEITYVSNSP SPGFNSSHNS
     FPIGEGNGSP NHQPEPPAPI VDVSAGLTPI QNLMPTSTPQ EAQQWLHRNR FAAFSRLFTN
     FSGADLLKLT REDVIQICGP ADGIRLFNAL KGRIVRPRLT IYVCQESQQL REQQQHKHEN
     GEPGNGAFYV YHAIYLEEMT TIELTEKIAQ LFSISPHQIN QIYKQGPTGI HVLISDEMIQ
     NFQDESCFIL DTMKAETNDS YHIILK