ID   TFCP2_XENTR             Reviewed;         507 AA.
AC   Q6NZH6;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Transcription factor CP2;
GN   Name=tfcp2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a transcription factor.
CC   -!- SUBUNIT: Component of the SSP (stage selector protein) complex, which
CC       appears to be a heteromer of TFCP2 and 2 copies of NFE4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the grh/CP2 family. CP2 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC066130; AAH66130.1; -; mRNA.
DR   RefSeq; NP_991396.1; NM_205827.1.
DR   AlphaFoldDB; Q6NZH6; -.
DR   SMR; Q6NZH6; -.
DR   Ensembl; ENSXETT00000085920; ENSXETP00000096781; ENSXETG00000009632.
DR   GeneID; 403094; -.
DR   KEGG; xtr:403094; -.
DR   CTD; 7024; -.
DR   Xenbase; XB-GENE-485720; tfcp2.
DR   InParanoid; Q6NZH6; -.
DR   OrthoDB; 386296at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000009632; Expressed in neurula embryo and 14 other tissues.
DR   ExpressionAtlas; Q6NZH6; baseline.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd09589; SAM_TFCP2; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR007604; CP2.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR041418; SAM_3.
DR   InterPro; IPR037599; TFCP2_SAM.
DR   Pfam; PF04516; CP2; 1.
DR   Pfam; PF18016; SAM_3; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS51968; GRH_CP2_DB; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..507
FT                   /note="Transcription factor CP2"
FT                   /id="PRO_0000228005"
FT   DOMAIN          61..300
FT                   /note="Grh/CP2 DB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01313"
FT   REGION          133..395
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          240..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          296..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..264
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   507 AA;  57634 MW;  CCE404A4C160FF46 CRC64;
     MAWALKLPLA DEVIESGLVQ DFDASLSGIG QELGAGAYSM SDVLALPIFK QEESSLPSEN
     ENKILPFQYV LCTATSPAVK LHEETLTYLN QGQSYEIRML DNRKMGELPE LNGKLVKSIF
     RVVFHDRRLQ YTEHQQLEGW RWNRPGDRIL DIDIPMSVGI IDPRANPTQL NTVEFLWDPA
     KRTSVFIQVH CISTEFTMRK HGGEKGVPFR VQIDTFKENE NGEYTEHLHS ASCQIKVFKP
     KGADRKQKTD REKMEKRTPQ EKEKYQPSYE TTILTECSPW PEITYVSNAP SPGFNSSHNS
     FPIGEGNGSP NHQPEPPAPI VDVSAGLTPI QNLLPTSTPQ EAQQWLHRNR FAAFSRLFTN
     FSGADLLKLT RDDVIQICGP ADGIRLFNAL KGRMVRPRLT IYVCQESQQL REQQQQHKHE
     NGEAGNSAFY VYHAIYLEEM TAIELTEKIA QLFSISPHQI NQIYKQGPTG IHVLISDEMI
     QNFQDESCFI LDTMKAETND SYHIILK