ID   TFDF1_CUPPJ             Reviewed;         354 AA.
AC   P27137; Q46M69;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Maleylacetate reductase 1;
DE            EC=1.3.1.32;
DE   AltName: Full=Maleylacetate reductase I;
GN   Name=tfdFI; Synonyms=tfdF; OrderedLocusNames=Reut_D6463;
OS   Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator
OS   (strain JMP 134)).
OG   Plasmid pJP4, and Plasmid pPJ4.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=264198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pJP4;
RX   PubMed=2185214; DOI=10.1128/jb.172.5.2351-2359.1990;
RA   Perkins E.J., Gordon M.P., Caceres O., Lurquin P.F.;
RT   "Organization and sequence analysis of the 2,4-dichlorophenol hydroxylase
RT   and dichlorocatechol oxidative operons of plasmid pJP4.";
RL   J. Bacteriol. 172:2351-2359(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   PLASMID=pJP4;
RX   PubMed=15186344; DOI=10.1111/j.1462-2920.2004.00596.x;
RA   Trefault N., De la Iglesia R., Molina A.M., Manzano M., Ledger T.,
RA   Perez-Pantoja D., Sanchez M.A., Stuardo M., Gonzalez B.;
RT   "Genetic organization of the catabolic plasmid pJP4 from Ralstonia eutropha
RT   JMP134 (pJP4) reveals mechanisms of adaptation to chloroaromatic pollutants
RT   and evolution of specialized chloroaromatic degradation pathways.";
RL   Environ. Microbiol. 6:655-668(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JMP134 / LMG 1197; PLASMID=pPJ4;
RX   PubMed=20339589; DOI=10.1371/journal.pone.0009729;
RA   Lykidis A., Perez-Pantoja D., Ledger T., Mavromatis K., Anderson I.J.,
RA   Ivanova N.N., Hooper S.D., Lapidus A., Lucas S., Gonzalez B.,
RA   Kyrpides N.C.;
RT   "The complete multipartite genome sequence of Cupriavidus necator JMP134, a
RT   versatile pollutant degrader.";
RL   PLoS ONE 5:E9729-E9729(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-oxoadipate + NAD(+) = H(+) + maleylacetate + NADH;
CC         Xref=Rhea:RHEA:16981, ChEBI:CHEBI:15378, ChEBI:CHEBI:15775,
CC         ChEBI:CHEBI:16468, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.32;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-oxoadipate + NADP(+) = H(+) + maleylacetate + NADPH;
CC         Xref=Rhea:RHEA:16985, ChEBI:CHEBI:15378, ChEBI:CHEBI:15775,
CC         ChEBI:CHEBI:16468, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.32;
CC   -!- PATHWAY: Aromatic compound metabolism; 3-chlorocatechol degradation.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase
CC       family. {ECO:0000305}.
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DR   EMBL; M35097; AAA98265.1; -; Genomic_DNA.
DR   EMBL; AY365053; AAR31036.1; -; Genomic_DNA.
DR   EMBL; CP000093; AAZ65761.1; -; Genomic_DNA.
DR   PIR; D35255; D35255.
DR   RefSeq; WP_011178383.1; NZ_AY365053.1.
DR   AlphaFoldDB; P27137; -.
DR   SMR; P27137; -.
DR   PRIDE; P27137; -.
DR   DNASU; 3607954; -.
DR   EnsemblBacteria; AAZ65761; AAZ65761; Reut_D6463.
DR   GeneID; 55536837; -.
DR   KEGG; reu:Reut_D6463; -.
DR   HOGENOM; CLU_007207_0_1_4; -.
DR   OMA; EMIATKG; -.
DR   OrthoDB; 1456634at2; -.
DR   BioCyc; MetaCyc:MON-14414; -.
DR   UniPathway; UPA00083; -.
DR   GO; GO:0018506; F:maleylacetate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:1901168; P:3-chlorocatechol catabolic process; IDA:CACAO.
DR   CDD; cd08177; MAR; 1.
DR   InterPro; IPR001670; ADH_Fe/GldA.
DR   InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR   InterPro; IPR034786; MAR.
DR   PANTHER; PTHR11496; PTHR11496; 1.
DR   Pfam; PF00465; Fe-ADH; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; NAD; Oxidoreductase; Plasmid.
FT   CHAIN           1..354
FT                   /note="Maleylacetate reductase 1"
FT                   /id="PRO_0000087851"
SQ   SEQUENCE   354 AA;  37900 MW;  7D88C001B5B13376 CRC64;
     MKKFTLDYLS PRVVFGAGTA SALPDEIGRL GARRPLVLSS PEQRELAKDI VRPIGDRVAG
     YFDGATMHVP VDVIQKAERA FNDTDADSII AIGGGSTTGL AKILSMNLDV PSLVIPTTYA
     GSEMTTIWGV TEGGMKRTGR DPKVLPKTVI YDPLLTVDLP LAISVTSALN AIAHAAEGLY
     SADLNPVLET MCKQGICALF DAIPRLVAKP TDAEARTDAL FGAWMCGTAL CHLGMGLHHK
     LCHTLGGTLN LPHAETHAIV LPHALAYNLP YAAPAERLLQ EVAGSSDVPS ALYDLARNAG
     APLSLAEIGM RPEDIPRVRD LALRDQYPNP RPLESDALET LLVNAFRGRR PDFK