ID   BRD9_XENTR              Reviewed;         596 AA.
AC   Q6NVM8;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Bromodomain-containing protein 9;
GN   Name=brd9;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in chromatin remodeling and regulation of
CC       transcription. Acts as a chromatin reader that recognizes and binds
CC       acylated histones: binds histones that are acetylated and/or
CC       butyrylated. {ECO:0000250|UniProtKB:Q9H8M2}.
CC   -!- SUBUNIT: Binds acetylated histones H3 and H4. Binds butyrylated histone
CC       H4. {ECO:0000250|UniProtKB:Q9H8M2}.
CC   -!- DOMAIN: The Bromo domain mediates interaction with histones that have
CC       acetylated lysine residues at specific positions. Also recognizes and
CC       binds histones that are butyrylated. {ECO:0000250|UniProtKB:Q9H8M2}.
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DR   EMBL; BC067977; AAH67977.1; -; mRNA.
DR   RefSeq; NP_998862.1; NM_213697.2.
DR   AlphaFoldDB; Q6NVM8; -.
DR   SMR; Q6NVM8; -.
DR   STRING; 8364.ENSXETP00000028698; -.
DR   PaxDb; Q6NVM8; -.
DR   PRIDE; Q6NVM8; -.
DR   GeneID; 407874; -.
DR   KEGG; xtr:407874; -.
DR   CTD; 65980; -.
DR   Xenbase; XB-GENE-969470; brd9.
DR   eggNOG; KOG1828; Eukaryota.
DR   InParanoid; Q6NVM8; -.
DR   OrthoDB; 439339at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0070577; F:lysine-acetylated histone binding; ISS:UniProtKB.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.20.920.10; -; 1.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR018359; Bromodomain_CS.
DR   InterPro; IPR021900; DUF3512.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF12024; DUF3512; 1.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00297; BROMO; 1.
DR   SUPFAM; SSF47370; SSF47370; 1.
DR   PROSITE; PS00633; BROMODOMAIN_1; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
PE   2: Evidence at transcript level;
KW   Bromodomain; Chromatin regulator; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..596
FT                   /note="Bromodomain-containing protein 9"
FT                   /id="PRO_0000239223"
FT   DOMAIN          165..235
FT                   /note="Bromo"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          49..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          226..228
FT                   /note="Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu
FT                   binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8M2"
FT   REGION          537..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..119
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        547..563
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            181
FT                   /note="Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu
FT                   binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8M2"
FT   SITE            234
FT                   /note="Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu
FT                   binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8M2"
SQ   SEQUENCE   596 AA;  67908 MW;  844B9154D65BECC5 CRC64;
     MGKKHKKHKS EWRSYDAGEL GSPGDQSQYY VDKPLEKPLK LVLKVGGSEV TELSGSGHDS
     SFYEDRSDHE RERHKEKKKK KKKKSEKEKD KYLDEDERRR RKEEKKRKRE KEQCDSEGET
     EVFESVRKVD IEATDRPVRA CRTHPAENES TPLQQLLEYF LRQLQRKDPN GFFAFPVTDQ
     IAPGYFMIIK NPMDFSTMKE KISQNEYKSV TEFKADFKLM CDNAMTYNRP ETVYYKLAKK
     LLHTGFKMMS KQAALLGDED TTTEEPTPEI IMPTAAEVVK KSKKPSKDMF RVMEEDQSSI
     FEPEGNACSL TDSTAEEHVL ALVEHAADEA RDKINRYLPN CRIGYLKKNA DGTLIYTVVN
     GDPENEEEDT HLVDLSSLSS KLLPSFTTLG FKEDRRHKVT FLNSTGTALS LQNNTLFTNL
     KPDQIDLMYA GYGDDTGIQC ALSLQEFVKD CGSFAKRMVN DLLDQITGGD HSRTIYQMAG
     SEREGSSNSV LDYMALKTYS DVSLDMSMLS SLDKVKKELE HEDSHLNLDD ASKLLPDFHD
     VHNDRGGSRP SSSSSVSNNS ERDHHLGSPS RISVGEQQDI HDPYEFLQSP ETENQN