ID   TFEC_BOVIN              Reviewed;         317 AA.
AC   A4IFU7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Transcription factor EC;
GN   Name=TFEC;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional regulator that acts as a repressor or an
CC       activator. Acts as a transcriptional repressor on minimal promoter
CC       containing element F (that includes an E-box sequence). Binds to
CC       element F in an E-box sequence-specific manner. Acts as a
CC       transcriptional transactivator on the proximal promoter region of the
CC       tartrate-resistant acid phosphatase (TRAP) E-box containing promoter.
CC       Collaborates with MITF in target gene activation. Acts as a
CC       transcriptional repressor on minimal promoter containing mu E3 enhancer
CC       sequence. Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain
CC       gene enhancer. Binds DNA in a homo- or heterodimeric form (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Forms heterodimers with MITF and TFE3. Interacts
CC       with MITF (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- SIMILARITY: Belongs to the MiT/TFE family. {ECO:0000305}.
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DR   EMBL; BC134774; AAI34775.1; -; mRNA.
DR   RefSeq; NP_001077208.1; NM_001083739.1.
DR   AlphaFoldDB; A4IFU7; -.
DR   SMR; A4IFU7; -.
DR   STRING; 9913.ENSBTAP00000018918; -.
DR   PaxDb; A4IFU7; -.
DR   GeneID; 539016; -.
DR   KEGG; bta:539016; -.
DR   CTD; 22797; -.
DR   eggNOG; KOG1318; Eukaryota.
DR   InParanoid; A4IFU7; -.
DR   OrthoDB; 1211990at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR021802; MiT/TFE_C.
DR   InterPro; IPR024101; TFEC.
DR   PANTHER; PTHR45776:SF1; PTHR45776:SF1; 2.
DR   Pfam; PF11851; DUF3371; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..317
FT                   /note="Transcription factor EC"
FT                   /id="PRO_0000313563"
FT   DOMAIN          110..163
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..90
FT                   /note="Necessary for transcriptional transactivation"
FT                   /evidence="ECO:0000250"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          241..317
FT                   /note="Necessary for transcriptional transactivation"
FT                   /evidence="ECO:0000250"
FT   REGION          297..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   317 AA;  35702 MW;  16D040A3EC01D1CF CRC64;
     MTLDHQILNQ SFKRSHPPTP SSELLVQHGH PSPESDTGLT GNPLTRLLTL GKEDDNTEWH
     VSGSILDVYS GEQEISPVNM GLTSASCPSS LPMKREITET DTRALAKERQ KKDNHNLIER
     RRRYNINYRI KELGTLIPKS NDPDMRWNKG TILKASVEYI KWLQKEQQRA QELEHRQKKL
     EQANRRLLLR IQELEIQARA HGLPTLASLV TVDLGAHITK QTHLEQNSGD YCQQLVLSQG
     TSPELCDQAM AFSDPLSHFT DLSFSAALKE EQRLDNMLLD DTVSPFGTDP LLSAISPAVS
     KESSRRSSFS SEDGDEL