ID   TFEC_CHICK              Reviewed;         377 AA.
AC   Q5XFQ6; Q6RCT8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Transcription factor EC;
DE            Short=TFE-C;
GN   Name=TFEC; Synonyms=TCFEC;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-200.
RA   Rowan S., Fisher D.E.;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=15459106; DOI=10.1242/dev.01300;
RA   Rowan S., Chen C.-M.A., Young T.L., Fisher D.E., Cepko C.L.;
RT   "Transdifferentiation of the retina into pigmented cells in ocular
RT   retardation mice defines a new function of the homeodomain gene Chx10.";
RL   Development 131:5139-5152(2004).
CC   -!- FUNCTION: Transcriptional regulator that acts as a repressor or an
CC       activator. Binds DNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- SIMILARITY: Belongs to the MiT/TFE family. {ECO:0000305}.
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DR   EMBL; AY502941; AAR83675.1; -; mRNA.
DR   EMBL; BK004078; DAA04569.1; -; mRNA.
DR   RefSeq; NP_001006229.2; NM_001006229.2.
DR   AlphaFoldDB; Q5XFQ6; -.
DR   SMR; Q5XFQ6; -.
DR   STRING; 9031.ENSGALP00000042575; -.
DR   PaxDb; Q5XFQ6; -.
DR   GeneID; 417773; -.
DR   KEGG; gga:417773; -.
DR   CTD; 22797; -.
DR   VEuPathDB; HostDB:geneid_417773; -.
DR   eggNOG; KOG1318; Eukaryota.
DR   InParanoid; Q5XFQ6; -.
DR   OrthoDB; 1211990at2759; -.
DR   PhylomeDB; Q5XFQ6; -.
DR   PRO; PR:Q5XFQ6; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR021802; MiT/TFE_C.
DR   InterPro; IPR031867; MiT/TFE_N.
DR   InterPro; IPR024101; TFEC.
DR   PANTHER; PTHR45776:SF1; PTHR45776:SF1; 1.
DR   Pfam; PF11851; DUF3371; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..377
FT                   /note="Transcription factor EC"
FT                   /id="PRO_0000313569"
FT   DOMAIN          169..222
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          349..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..365
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   377 AA;  42515 MW;  BC3999F4DD66B354 CRC64;
     MVWVRRWGTT HLENQSRYHI QQSQRYQVKQ YLTLDTKLSS QTLSLSHSHT VQPTGVTSIF
     RNGHMPPVSD IGTPESPVTK LLALGGEHEN AMEEVIEDII NMESSFNDEG IGCSETPLLM
     QRTSILDIYN SDQGMAPANM SLTNASCPAN LPVKRELTAD TRAMAKERQK KDNHNLIERR
     RRYNINYRIK ELGTLIPKSN DPDMRWNKGT ILKASVEYIK WLQKEQQRAR ELEHRQKKLE
     HANRRLLLRI QELEIQARAH GLPVMSSLSA VDLAAQVIKQ QSYPEENSVD YSQQMPLAHG
     PNSDVCDGST AFSDPLSHFT DLSFSAALKE EQQLEEILLD DTVSPFGADP LLSSTSPAAS
     KESSRRSSFS TDDGDDL