TFEC_RAT
ID TFEC_RAT Reviewed; 317 AA.
AC Q63302;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Transcription factor EC;
DE Short=TFE-C;
DE Short=rTFEC;
GN Name=Tfec; Synonyms=Tcfec;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, DEVELOPMENTAL STAGE, AND
RP TISSUE SPECIFICITY.
RC TISSUE=Chondrosarcoma;
RX PubMed=8336698; DOI=10.1128/mcb.13.8.4505-4512.1993;
RA Zhao G.Q., Zhao Q., Zhou X., Mattei M.-G., de Crombrugghe B.;
RT "TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and
RT inhibits TFE3-dependent transcription activation.";
RL Mol. Cell. Biol. 13:4505-4512(1993).
CC -!- FUNCTION: Transcriptional regulator that acts as a repressor or an
CC activator. Acts as a transcriptional repressor on minimal promoter
CC containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the
CC immunoglobulin heavy-chain gene enhancer. Acts as a transcriptional
CC transactivator on the proximal promoter region of the tartrate-
CC resistant acid phosphatase (TRAP) E-box containing promoter (By
CC similarity). Collaborates with MITF in target gene activation (By
CC similarity). Acts as a transcriptional repressor on minimal promoter
CC containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA
CC sequence of the immunoglobulin heavy-chain gene enhancer (By
CC similarity). Binds DNA in a homo- or heterodimeric form. {ECO:0000250,
CC ECO:0000269|PubMed:8336698}.
CC -!- SUBUNIT: Homodimer. Forms heterodimers with TFE3. Forms heterodimers
CC with MITF (By similarity). Interacts with MITF (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed in kidney, spleen, lung, liver, testis
CC and muscle. {ECO:0000269|PubMed:8336698}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryo at 14 dpc and in skeletal
CC muscle at 18 dpc. {ECO:0000269|PubMed:8336698}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA41523.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAA41523.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; L08812; AAA41523.1; ALT_SEQ; mRNA.
DR RefSeq; NP_071774.1; NM_022379.1.
DR AlphaFoldDB; Q63302; -.
DR SMR; Q63302; -.
DR STRING; 10116.ENSRNOP00000008156; -.
DR PaxDb; Q63302; -.
DR Ensembl; ENSRNOT00000086810; ENSRNOP00000073175; ENSRNOG00000061595.
DR GeneID; 26296; -.
DR KEGG; rno:26296; -.
DR UCSC; RGD:3846; rat.
DR CTD; 22797; -.
DR RGD; 3846; Tfec.
DR eggNOG; KOG1318; Eukaryota.
DR GeneTree; ENSGT00940000159404; -.
DR HOGENOM; CLU_031638_0_0_1; -.
DR InParanoid; Q63302; -.
DR OMA; ICPFGTD; -.
DR OrthoDB; 1211990at2759; -.
DR PhylomeDB; Q63302; -.
DR TreeFam; TF317174; -.
DR PRO; PR:Q63302; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000061595; Expressed in adult mammalian kidney and 14 other tissues.
DR Genevisible; Q63302; RN.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0034605; P:cellular response to heat; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:RGD.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR024101; TFEC.
DR PANTHER; PTHR45776:SF1; PTHR45776:SF1; 2.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..317
FT /note="Transcription factor EC"
FT /id="PRO_0000313568"
FT DOMAIN 110..163
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..90
FT /note="Necessary for transcriptional transactivation"
FT /evidence="ECO:0000250"
FT REGION 242..317
FT /note="Necessary for transcriptional transactivation"
FT /evidence="ECO:0000250"
SQ SEQUENCE 317 AA; 35175 MW; A68AC4E7F245E3DB CRC64;
MTLDHRLFSQ TLKRAQPLAA SCMPLAEHGP RSPDSDAGCA GNPFTNPLAL GKEDGVVEWR
LSGSILDVYS GEQGISPVNT GLMNASCPSI LPMKKEIAET DTRALAKERQ KKDNHNLIER
RRRYNINYRI KELGTLIPKS NDPDIRWNKG TILKASVDYI KWLQKEQQRA RELEHRQKKL
EHANRQLMLR IQELEIQARA HGLPILASLG TADFGTHITK QQTHSEKNSV GCCQQLTPSQ
GTSPEFYEQA VAFSDPLSHF TDLSFSAALK EEQRLDGMLL SDTICPFGTD PLLSAISPAV
SKASSRSSLS SEDGDEL
