ID   TFF1_CANLF              Reviewed;          81 AA.
AC   Q863T4;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Trefoil factor 1;
DE   Flags: Precursor;
GN   Name=TFF1;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Stomach;
RA   Campbell B.G., Jabbes M.;
RT   "Canine trefoil factor 1 (TFF1) mRNA from gastric mucosa.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stabilizer of the mucous gel overlying the gastrointestinal
CC       mucosa that provides a physical barrier against various noxious agents.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; AY258287; AAP14905.1; -; mRNA.
DR   RefSeq; NP_001002992.1; NM_001002992.1.
DR   AlphaFoldDB; Q863T4; -.
DR   SMR; Q863T4; -.
DR   STRING; 9615.ENSCAFP00000050000; -.
DR   PaxDb; Q863T4; -.
DR   PRIDE; Q863T4; -.
DR   GeneID; 403491; -.
DR   KEGG; cfa:403491; -.
DR   CTD; 7031; -.
DR   eggNOG; ENOG502S00P; Eukaryota.
DR   HOGENOM; CLU_179440_1_0_1; -.
DR   InParanoid; Q863T4; -.
DR   OMA; RGFPWCF; -.
DR   OrthoDB; 1563185at2759; -.
DR   TreeFam; TF336092; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030277; P:maintenance of gastrointestinal epithelium; IBA:GO_Central.
DR   CDD; cd00111; Trefoil; 1.
DR   Gene3D; 4.10.110.10; -; 1.
DR   InterPro; IPR017994; P_trefoil_chordata.
DR   InterPro; IPR017957; P_trefoil_CS.
DR   InterPro; IPR000519; P_trefoil_dom.
DR   InterPro; IPR044913; P_trefoil_dom_sf.
DR   PANTHER; PTHR13826; PTHR13826; 1.
DR   Pfam; PF00088; Trefoil; 1.
DR   PRINTS; PR00680; PTREFOIL.
DR   SMART; SM00018; PD; 1.
DR   SUPFAM; SSF57492; SSF57492; 1.
DR   PROSITE; PS00025; P_TREFOIL_1; 1.
DR   PROSITE; PS51448; P_TREFOIL_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..81
FT                   /note="Trefoil factor 1"
FT                   /id="PRO_0000023455"
FT   DOMAIN          26..69
FT                   /note="P-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        28..54
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        38..53
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        48..65
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
SQ   SEQUENCE   81 AA;  8926 MW;  BE85413B9DF82E1A CRC64;
     MEHRVIYVLV LVCALTLSSL AQGQQETCTV APHHRDNCGS PGITPSQCKD KGCCFDNTVR
     GVPWCYYPVA VDNPPEEECP F