TFF1_MOUSE
ID TFF1_MOUSE Reviewed; 87 AA.
AC Q08423; Q3TVE6;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Trefoil factor 1;
DE AltName: Full=Protein pS2;
DE Flags: Precursor;
GN Name=Tff1; Synonyms=Bcei, Ps2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8314841; DOI=10.1083/jcb.122.1.191;
RA Lefebvre O., Wolf C., Kedinger M., Chenard M.-P., Tomasetto C., Chambon P.,
RA Rio M.-C.;
RT "The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct
RT patterns of expression.";
RL J. Cell Biol. 122:191-198(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11290420; DOI=10.1016/s0378-1119(01)00380-8;
RA Ribieras S., Lefebvre O., Tomasetto C., Rio M.C.;
RT "Mouse trefoil factor genes: genomic organization, sequences and
RT methylation analyses.";
RL Gene 266:67-75(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Stomach, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Stabilizer of the mucous gel overlying the gastrointestinal
CC mucosa that provides a physical barrier against various noxious agents.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Strong expression found in normal gastric mucosa.
CC Not detected in the small or large intestine nor in normal mammary
CC gland.
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DR EMBL; Z21858; CAA79913.1; -; mRNA.
DR EMBL; AJ271002; CAB65750.1; -; Genomic_DNA.
DR EMBL; AK008625; BAB25787.1; -; mRNA.
DR EMBL; AK008809; BAB25907.1; -; mRNA.
DR EMBL; AK008873; BAB25943.1; -; mRNA.
DR EMBL; AK010179; BAB26751.1; -; mRNA.
DR EMBL; AK131896; BAE20857.1; -; mRNA.
DR EMBL; AK160174; BAE35673.1; -; mRNA.
DR CCDS; CCDS37546.1; -.
DR PIR; A40700; A40700.
DR RefSeq; NP_033388.1; NM_009362.2.
DR AlphaFoldDB; Q08423; -.
DR SMR; Q08423; -.
DR STRING; 10090.ENSMUSP00000024831; -.
DR PaxDb; Q08423; -.
DR PeptideAtlas; Q08423; -.
DR PRIDE; Q08423; -.
DR ProteomicsDB; 262892; -.
DR Antibodypedia; 1095; 938 antibodies from 39 providers.
DR DNASU; 21784; -.
DR Ensembl; ENSMUST00000024831; ENSMUSP00000024831; ENSMUSG00000024032.
DR GeneID; 21784; -.
DR KEGG; mmu:21784; -.
DR UCSC; uc008buo.1; mouse.
DR CTD; 7031; -.
DR MGI; MGI:88135; Tff1.
DR VEuPathDB; HostDB:ENSMUSG00000024032; -.
DR eggNOG; ENOG502S00P; Eukaryota.
DR GeneTree; ENSGT00940000162623; -.
DR HOGENOM; CLU_179440_1_0_1; -.
DR InParanoid; Q08423; -.
DR OMA; RGFPWCF; -.
DR OrthoDB; 1563185at2759; -.
DR PhylomeDB; Q08423; -.
DR TreeFam; TF336092; -.
DR BioGRID-ORCS; 21784; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Tff1; mouse.
DR PRO; PR:Q08423; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q08423; protein.
DR Bgee; ENSMUSG00000024032; Expressed in pyloric antrum and 122 other tissues.
DR ExpressionAtlas; Q08423; baseline and differential.
DR Genevisible; Q08423; MM.
DR GO; GO:0005737; C:cytoplasm; TAS:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IMP:MGI.
DR GO; GO:0008283; P:cell population proliferation; IMP:MGI.
DR GO; GO:0030277; P:maintenance of gastrointestinal epithelium; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:MGI.
DR GO; GO:0009611; P:response to wounding; TAS:MGI.
DR CDD; cd00111; Trefoil; 1.
DR Gene3D; 4.10.110.10; -; 1.
DR InterPro; IPR017994; P_trefoil_chordata.
DR InterPro; IPR017957; P_trefoil_CS.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR PANTHER; PTHR13826; PTHR13826; 1.
DR Pfam; PF00088; Trefoil; 1.
DR PRINTS; PR00680; PTREFOIL.
DR SMART; SM00018; PD; 1.
DR SUPFAM; SSF57492; SSF57492; 1.
DR PROSITE; PS00025; P_TREFOIL_1; 1.
DR PROSITE; PS51448; P_TREFOIL_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Growth factor; Pyrrolidone carboxylic acid;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /note="Or 23"
FT /evidence="ECO:0000255"
FT CHAIN 22..87
FT /note="Trefoil factor 1"
FT /id="PRO_0000023457"
FT DOMAIN 32..75
FT /note="P-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT MOD_RES 22
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000255"
FT DISULFID 34..60
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 44..59
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 54..71
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
SQ SEQUENCE 87 AA; 9670 MW; 193B9ED3D72E71DC CRC64;
MEHKVICVLA VVLMLAFGSL AQAQAQAQAQ EETCIMAPRE RINCGFPGVT AQQCTERGCC
FDDSVRGFPW CFHPMAIENT QEEECPF
