TFF1_RAT
ID TFF1_RAT Reviewed; 81 AA.
AC Q63467;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Trefoil factor 1;
DE AltName: Full=Protein pS2;
DE Flags: Precursor;
GN Name=Tff1; Synonyms=Ps2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar; TISSUE=Stomach;
RX PubMed=8836141; DOI=10.1042/bj3180939;
RA Itoh H., Tomita M., Uchino H., Kobayashi T., Kataoka H., Sekiya R.,
RA Nawa Y.;
RT "cDNA cloning of rat pS2 peptide and expression of trefoil peptides in
RT acetic acid-induced colitis.";
RL Biochem. J. 318:939-944(1996).
CC -!- FUNCTION: Stabilizer of the mucous gel overlying the gastrointestinal
CC mucosa that provides a physical barrier against various noxious agents.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
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DR EMBL; D83231; BAA11857.1; -; mRNA.
DR PIR; S71962; S71962.
DR RefSeq; NP_476470.1; NM_057129.1.
DR AlphaFoldDB; Q63467; -.
DR SMR; Q63467; -.
DR STRING; 10116.ENSRNOP00000001538; -.
DR PaxDb; Q63467; -.
DR Ensembl; ENSRNOT00000001538; ENSRNOP00000001538; ENSRNOG00000001164.
DR GeneID; 117270; -.
DR KEGG; rno:117270; -.
DR UCSC; RGD:620707; rat.
DR CTD; 7031; -.
DR RGD; 620707; Tff1.
DR eggNOG; ENOG502S00P; Eukaryota.
DR GeneTree; ENSGT00940000162623; -.
DR HOGENOM; CLU_179440_1_0_1; -.
DR InParanoid; Q63467; -.
DR OMA; RGFPWCF; -.
DR OrthoDB; 1563185at2759; -.
DR PhylomeDB; Q63467; -.
DR TreeFam; TF336092; -.
DR PRO; PR:Q63467; -.
DR Proteomes; UP000002494; Chromosome 20.
DR Bgee; ENSRNOG00000001164; Expressed in stomach and 12 other tissues.
DR Genevisible; Q63467; RN.
DR GO; GO:0005737; C:cytoplasm; TAS:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; ISO:RGD.
DR GO; GO:0030277; P:maintenance of gastrointestinal epithelium; IEP:RGD.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0035902; P:response to immobilization stress; IEP:RGD.
DR GO; GO:0010039; P:response to iron ion; IEP:RGD.
DR GO; GO:0043434; P:response to peptide hormone; IEP:RGD.
DR GO; GO:0042060; P:wound healing; TAS:RGD.
DR CDD; cd00111; Trefoil; 1.
DR Gene3D; 4.10.110.10; -; 1.
DR InterPro; IPR017994; P_trefoil_chordata.
DR InterPro; IPR017957; P_trefoil_CS.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR PANTHER; PTHR13826; PTHR13826; 1.
DR Pfam; PF00088; Trefoil; 1.
DR PRINTS; PR00680; PTREFOIL.
DR SMART; SM00018; PD; 1.
DR SUPFAM; SSF57492; SSF57492; 1.
DR PROSITE; PS00025; P_TREFOIL_1; 1.
DR PROSITE; PS51448; P_TREFOIL_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Growth factor; Pyrrolidone carboxylic acid;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..81
FT /note="Trefoil factor 1"
FT /id="PRO_0000023458"
FT DOMAIN 26..69
FT /note="P-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT MOD_RES 22
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000255"
FT DISULFID 28..54
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 38..53
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 48..65
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
SQ SEQUENCE 81 AA; 9155 MW; 56740550406ECF25 CRC64;
MEHKVTCVLA MVLMLALSSL AQNQEETCAV IPRERINCGF PGVTAQQCKE KGCCFDDSVR
GFPWCFRPLV IENQQEEECP F
