TFF2_CANLF
ID TFF2_CANLF Reviewed; 129 AA.
AC Q863J2;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Trefoil factor 2;
DE Flags: Precursor;
GN Name=TFF2;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Gastric mucosa;
RA Campbell B.G., Jabbes M.;
RT "Canine trefoil factor 2 (TFF2) mRNA from gastric mucosa.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits gastrointestinal motility and gastric acid
CC secretion. Could function as a structural component of gastric mucus,
CC possibly by stabilizing glycoproteins in the mucus gel through
CC interactions with carbohydrate side chains (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR EMBL; AY264843; AAP21820.1; -; mRNA.
DR RefSeq; NP_001002991.1; NM_001002991.1.
DR AlphaFoldDB; Q863J2; -.
DR SMR; Q863J2; -.
DR STRING; 9615.ENSCAFP00000057618; -.
DR PaxDb; Q863J2; -.
DR PRIDE; Q863J2; -.
DR GeneID; 403489; -.
DR KEGG; cfa:403489; -.
DR CTD; 7032; -.
DR eggNOG; ENOG502S5ZY; Eukaryota.
DR InParanoid; Q863J2; -.
DR OrthoDB; 1563185at2759; -.
DR Proteomes; UP000002254; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031723; F:CXCR4 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0030277; P:maintenance of gastrointestinal epithelium; IBA:GO_Central.
DR GO; GO:0060455; P:negative regulation of gastric acid secretion; IBA:GO_Central.
DR CDD; cd00111; Trefoil; 2.
DR Gene3D; 4.10.110.10; -; 2.
DR InterPro; IPR017994; P_trefoil_chordata.
DR InterPro; IPR017957; P_trefoil_CS.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR PANTHER; PTHR13826; PTHR13826; 1.
DR Pfam; PF00088; Trefoil; 2.
DR PRINTS; PR00680; PTREFOIL.
DR SMART; SM00018; PD; 2.
DR SUPFAM; SSF57492; SSF57492; 2.
DR PROSITE; PS00025; P_TREFOIL_1; 2.
DR PROSITE; PS51448; P_TREFOIL_2; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Pyrrolidone carboxylic acid; Reference proteome; Repeat;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..129
FT /note="Trefoil factor 2"
FT /id="PRO_0000023459"
FT DOMAIN 29..73
FT /note="P-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DOMAIN 79..122
FT /note="P-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT MOD_RES 24
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P01359"
FT DISULFID 29..127
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 31..58
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 42..57
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 52..69
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 81..107
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 91..106
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 101..118
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
SQ SEQUENCE 129 AA; 14102 MW; D0AE5DAB4CE6ABE0 CRC64;
MGPRGLQLLA VLLALGLCAP AGAQKPSACQ CSRIEASHRK NCGFPGISAS ECFNTGCCFD
SRVPNVPWCF HPLPKQESEQ CVMEVAARKN CGYPGISPQE CASRNCCFSD TIRNVPWCFF
PILNQDCHY
