TFF2_HUMAN
ID TFF2_HUMAN Reviewed; 129 AA.
AC Q03403; Q15854;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Trefoil factor 2;
DE AltName: Full=Spasmolysin;
DE AltName: Full=Spasmolytic polypeptide;
DE Short=SP;
DE Flags: Precursor;
GN Name=TFF2; Synonyms=SML1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Stomach;
RX PubMed=2303034; DOI=10.1002/j.1460-2075.1990.tb08125.x;
RA Tomasetto C., Rio M.C., Gautier C., Wolf C., Hareuveni M., Chambon P.,
RA Lathe R.;
RT "hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with
RT pS2 in stomach but not in breast carcinoma.";
RL EMBO J. 9:407-414(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9070946; DOI=10.1006/geno.1996.4511;
RA Seib T., Blin N., Hilgert K., Seifert M., Theisinger B., Engel M.,
RA Dooley S., Zang K.D., Welter C.;
RT "The three human trefoil genes TFF1, TFF2, and TFF3 are located within a
RT region of 55 kb on chromosome 21q22.3.";
RL Genomics 40:200-202(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10950923; DOI=10.1006/geno.2000.6253;
RA Berry A., Scott H.S., Kudoh J., Talior I., Korostishevsky M.,
RA Wattenhofer M., Guipponi M., Barras C., Rossier C., Shibuya K., Wang J.,
RA Kawasaki K., Asakawa S., Minoshima S., Shimizu N., Antonarakis S.E.,
RA Bonne-Tamir B.;
RT "Refined localization of autosomal recessive nonsyndromic deafness DFNB10
RT locus using 34 novel microsatellite markers, genomic structure, and
RT exclusion of six known genes in the region.";
RL Genomics 68:22-29(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inhibits gastrointestinal motility and gastric acid
CC secretion. Could function as a structural component of gastric mucus,
CC possibly by stabilizing glycoproteins in the mucus gel through
CC interactions with carbohydrate side chains (By similarity).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q03403; O00571: DDX3X; NbExp=3; IntAct=EBI-4314702, EBI-353779;
CC Q03403; P25685: DNAJB1; NbExp=3; IntAct=EBI-4314702, EBI-357034;
CC Q03403; P50570-2: DNM2; NbExp=3; IntAct=EBI-4314702, EBI-10968534;
CC Q03403; Q12926-2: ELAVL2; NbExp=3; IntAct=EBI-4314702, EBI-11075944;
CC Q03403; Q96PJ5: FCRL4; NbExp=3; IntAct=EBI-4314702, EBI-4314687;
CC Q03403; P42858: HTT; NbExp=18; IntAct=EBI-4314702, EBI-466029;
CC Q03403; Q96HC4-3: PDLIM5; NbExp=3; IntAct=EBI-4314702, EBI-25913059;
CC Q03403; P62308: SNRPG; NbExp=3; IntAct=EBI-4314702, EBI-624585;
CC Q03403; Q15545: TAF7; NbExp=3; IntAct=EBI-4314702, EBI-1560194;
CC Q03403; P07437: TUBB; NbExp=3; IntAct=EBI-4314702, EBI-350864;
CC Q03403; A0A024R8L5: WIPI1; NbExp=3; IntAct=EBI-4314702, EBI-25923668;
CC Q03403; Q9Y6X8: ZHX2; NbExp=3; IntAct=EBI-4314702, EBI-948566;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Stomach.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/TFF2ID264.html";
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DR EMBL; X51698; CAA35995.1; -; mRNA.
DR EMBL; U47292; AAB05397.1; -; Genomic_DNA.
DR EMBL; U47289; AAB05397.1; JOINED; Genomic_DNA.
DR EMBL; U47290; AAB05397.1; JOINED; Genomic_DNA.
DR EMBL; U47291; AAB05397.1; JOINED; Genomic_DNA.
DR EMBL; AB038162; BAB13730.1; -; Genomic_DNA.
DR EMBL; BC032820; AAH32820.1; -; mRNA.
DR CCDS; CCDS13684.1; -.
DR PIR; S12371; S12371.
DR RefSeq; NP_005414.1; NM_005423.4.
DR AlphaFoldDB; Q03403; -.
DR SMR; Q03403; -.
DR BioGRID; 112890; 1.
DR IntAct; Q03403; 13.
DR STRING; 9606.ENSP00000291526; -.
DR DrugBank; DB03088; Pidolic acid.
DR iPTMnet; Q03403; -.
DR PhosphoSitePlus; Q03403; -.
DR BioMuta; TFF2; -.
DR DMDM; 2833194; -.
DR jPOST; Q03403; -.
DR MassIVE; Q03403; -.
DR PaxDb; Q03403; -.
DR PeptideAtlas; Q03403; -.
DR PRIDE; Q03403; -.
DR ProteomicsDB; 58207; -.
DR Antibodypedia; 23779; 365 antibodies from 35 providers.
DR DNASU; 7032; -.
DR Ensembl; ENST00000291526.5; ENSP00000291526.4; ENSG00000160181.9.
DR GeneID; 7032; -.
DR KEGG; hsa:7032; -.
DR MANE-Select; ENST00000291526.5; ENSP00000291526.4; NM_005423.5; NP_005414.1.
DR UCSC; uc002zaw.4; human.
DR CTD; 7032; -.
DR DisGeNET; 7032; -.
DR GeneCards; TFF2; -.
DR HGNC; HGNC:11756; TFF2.
DR HPA; ENSG00000160181; Tissue enriched (stomach).
DR MIM; 182590; gene.
DR neXtProt; NX_Q03403; -.
DR OpenTargets; ENSG00000160181; -.
DR PharmGKB; PA36471; -.
DR VEuPathDB; HostDB:ENSG00000160181; -.
DR eggNOG; ENOG502S5ZY; Eukaryota.
DR GeneTree; ENSGT00940000161334; -.
DR HOGENOM; CLU_161058_0_0_1; -.
DR InParanoid; Q03403; -.
DR OMA; WCFYPLP; -.
DR OrthoDB; 1563185at2759; -.
DR PhylomeDB; Q03403; -.
DR TreeFam; TF336092; -.
DR PathwayCommons; Q03403; -.
DR SignaLink; Q03403; -.
DR BioGRID-ORCS; 7032; 11 hits in 1070 CRISPR screens.
DR ChiTaRS; TFF2; human.
DR GeneWiki; Trefoil_factor_2; -.
DR GenomeRNAi; 7032; -.
DR Pharos; Q03403; Tbio.
DR PRO; PR:Q03403; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q03403; protein.
DR Bgee; ENSG00000160181; Expressed in pancreatic ductal cell and 105 other tissues.
DR Genevisible; Q03403; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031723; F:CXCR4 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0030277; P:maintenance of gastrointestinal epithelium; IBA:GO_Central.
DR GO; GO:0060455; P:negative regulation of gastric acid secretion; IBA:GO_Central.
DR CDD; cd00111; Trefoil; 2.
DR Gene3D; 4.10.110.10; -; 2.
DR InterPro; IPR017994; P_trefoil_chordata.
DR InterPro; IPR017957; P_trefoil_CS.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR PANTHER; PTHR13826; PTHR13826; 1.
DR Pfam; PF00088; Trefoil; 2.
DR PRINTS; PR00680; PTREFOIL.
DR SMART; SM00018; PD; 2.
DR SUPFAM; SSF57492; SSF57492; 2.
DR PROSITE; PS00025; P_TREFOIL_1; 2.
DR PROSITE; PS51448; P_TREFOIL_2; 2.
PE 1: Evidence at protein level;
KW Disulfide bond; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..129
FT /note="Trefoil factor 2"
FT /id="PRO_0000023460"
FT DOMAIN 29..73
FT /note="P-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DOMAIN 79..122
FT /note="P-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 29..127
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 31..58
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 42..57
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 52..69
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 81..107
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 91..106
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 101..118
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT VARIANT 3
FT /note="R -> W (in dbSNP:rs7277409)"
FT /id="VAR_053564"
FT CONFLICT 1..19
FT /note="MGRRDAQLLAALLVLGLCA -> RHGTARRPAPGSAPRPGAMC (in Ref.
FT 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 122
FT /note="K -> N (in Ref. 1; CAA35995)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 129 AA; 14284 MW; 6A296A11AD9CCC5D CRC64;
MGRRDAQLLA ALLVLGLCAL AGSEKPSPCQ CSRLSPHNRT NCGFPGITSD QCFDNGCCFD
SSVTGVPWCF HPLPKQESDQ CVMEVSDRRN CGYPGISPEE CASRKCCFSN FIFEVPWCFF
PKSVEDCHY
