TFF2_MOUSE
ID TFF2_MOUSE Reviewed; 129 AA.
AC Q03404; O08913;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Trefoil factor 2;
DE AltName: Full=Spasmolytic polypeptide;
DE Short=SP;
DE Flags: Precursor;
GN Name=Tff2; Synonyms=Sml1, Sp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE OF 2-129.
RC TISSUE=Pancreas, and Stomach;
RX PubMed=2303034; DOI=10.1002/j.1460-2075.1990.tb08125.x;
RA Tomasetto C., Rio M.C., Gautier C., Wolf C., Hareuveni M., Chambon P.,
RA Lathe R.;
RT "hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with
RT pS2 in stomach but not in breast carcinoma.";
RL EMBO J. 9:407-414(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=129/Sv;
RA Taupin D., Bei H., Hocker M., Wang T., Podolsky D.;
RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Inhibits gastrointestinal motility and gastric acid
CC secretion. Could function as a structural component of gastric mucus,
CC possibly by stabilizing glycoproteins in the mucus gel through
CC interactions with carbohydrate side chains (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Stomach and pancreas.
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DR EMBL; X51697; CAA35994.1; -; mRNA.
DR EMBL; U78770; AAB58490.1; -; Genomic_DNA.
DR CCDS; CCDS37545.1; -.
DR PIR; S12372; S12372.
DR AlphaFoldDB; Q03404; -.
DR SMR; Q03404; -.
DR STRING; 10090.ENSMUSP00000024826; -.
DR PhosphoSitePlus; Q03404; -.
DR MaxQB; Q03404; -.
DR PaxDb; Q03404; -.
DR PRIDE; Q03404; -.
DR ProteomicsDB; 262799; -.
DR MGI; MGI:1306805; Tff2.
DR eggNOG; ENOG502S5ZY; Eukaryota.
DR InParanoid; Q03404; -.
DR PhylomeDB; Q03404; -.
DR ChiTaRS; Tff2; mouse.
DR PRO; PR:Q03404; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q03404; protein.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0031723; F:CXCR4 chemokine receptor binding; IDA:MGI.
DR GO; GO:0019722; P:calcium-mediated signaling; IDA:MGI.
DR GO; GO:0008283; P:cell population proliferation; IMP:MGI.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IGI:MGI.
DR GO; GO:0051649; P:establishment of localization in cell; IMP:MGI.
DR GO; GO:0001696; P:gastric acid secretion; IMP:MGI.
DR GO; GO:0042116; P:macrophage activation; IMP:MGI.
DR GO; GO:0030277; P:maintenance of gastrointestinal epithelium; IBA:GO_Central.
DR GO; GO:0060455; P:negative regulation of gastric acid secretion; IMP:MGI.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IMP:MGI.
DR GO; GO:0043031; P:negative regulation of macrophage activation; IMP:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IGI:MGI.
DR GO; GO:0030334; P:regulation of cell migration; IGI:MGI.
DR CDD; cd00111; Trefoil; 2.
DR Gene3D; 4.10.110.10; -; 2.
DR InterPro; IPR017994; P_trefoil_chordata.
DR InterPro; IPR017957; P_trefoil_CS.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR PANTHER; PTHR13826; PTHR13826; 1.
DR Pfam; PF00088; Trefoil; 2.
DR PRINTS; PR00680; PTREFOIL.
DR SMART; SM00018; PD; 2.
DR SUPFAM; SSF57492; SSF57492; 2.
DR PROSITE; PS00025; P_TREFOIL_1; 2.
DR PROSITE; PS51448; P_TREFOIL_2; 2.
PE 1: Evidence at protein level;
KW Disulfide bond; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..129
FT /note="Trefoil factor 2"
FT /id="PRO_0000023461"
FT DOMAIN 29..73
FT /note="P-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DOMAIN 79..122
FT /note="P-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 29..127
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 31..58
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 42..57
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 52..69
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 81..107
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 91..106
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 101..118
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
SQ SEQUENCE 129 AA; 14172 MW; 25A37794199175D4 CRC64;
MGPRGAPLLA VVLVLGLHAL VEGEKPSPCR CSRLTPHNRK NCGFPGITSE QCFDLGCCFD
SSVAGVPWCF HPLPNQESEQ CVMEVSARKN CGYPGISPED CASRNCCFSN LIFEVPWCFF
PQSVEDCHY
