ID   TFF3_BOVIN              Reviewed;          81 AA.
AC   A8YXX7;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Trefoil factor 3;
DE   AltName: Full=Intestinal trefoil factor;
DE   Flags: Precursor;
GN   Name=TFF3; Synonyms=ITF;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the maintenance and repair of the intestinal
CC       mucosa. Promotes the mobility of epithelial cells in healing processes
CC       (motogen) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250|UniProtKB:Q07654}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q07654}.
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DR   EMBL; BC102088; AAI02089.1; -; mRNA.
DR   RefSeq; NP_001107981.1; NM_001114509.2.
DR   AlphaFoldDB; A8YXX7; -.
DR   SMR; A8YXX7; -.
DR   STRING; 9913.ENSBTAP00000028349; -.
DR   PaxDb; A8YXX7; -.
DR   Ensembl; ENSBTAT00000028349; ENSBTAP00000028349; ENSBTAG00000021276.
DR   GeneID; 517889; -.
DR   KEGG; bta:517889; -.
DR   CTD; 7033; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021276; -.
DR   VGNC; VGNC:35792; TFF3.
DR   eggNOG; ENOG502SV7V; Eukaryota.
DR   GeneTree; ENSGT00940000162416; -.
DR   InParanoid; A8YXX7; -.
DR   OMA; QETECTF; -.
DR   OrthoDB; 1563185at2759; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000021276; Expressed in urinary bladder and 79 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0030277; P:maintenance of gastrointestinal epithelium; IBA:GO_Central.
DR   GO; GO:0010906; P:regulation of glucose metabolic process; IEA:Ensembl.
DR   CDD; cd00111; Trefoil; 1.
DR   Gene3D; 4.10.110.10; -; 1.
DR   InterPro; IPR017994; P_trefoil_chordata.
DR   InterPro; IPR017957; P_trefoil_CS.
DR   InterPro; IPR000519; P_trefoil_dom.
DR   InterPro; IPR044913; P_trefoil_dom_sf.
DR   PANTHER; PTHR13826; PTHR13826; 1.
DR   Pfam; PF00088; Trefoil; 1.
DR   PRINTS; PR00680; PTREFOIL.
DR   SMART; SM00018; PD; 1.
DR   SUPFAM; SSF57492; SSF57492; 1.
DR   PROSITE; PS00025; P_TREFOIL_1; 1.
DR   PROSITE; PS51448; P_TREFOIL_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Disulfide bond; Extracellular matrix; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..81
FT                   /note="Trefoil factor 3"
FT                   /id="PRO_0000376809"
FT   DOMAIN          31..74
FT                   /note="P-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        33..59
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        43..58
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        53..70
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        79
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
SQ   SEQUENCE   81 AA;  8791 MW;  4734106A086EE105 CRC64;
     MEARTFWLLV VAVLALGSSS STGQYVGLSA NQCAVPAKDR VDCGYPEVTP EQCNNRGCCF
     DSSIHGVPWC FKPLQEAECT F