TFF3_CANLF
ID TFF3_CANLF Reviewed; 80 AA.
AC Q863B4;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Trefoil factor 3;
DE AltName: Full=Intestinal trefoil factor;
DE Flags: Precursor;
GN Name=TFF3; Synonyms=ITF;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Colon mucosa;
RA Campbell B.G., Jabbes M.;
RT "Canine trefoil factor 3 (TFF3) mRNA from colonic mucosa.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the maintenance and repair of the intestinal
CC mucosa. Promotes the mobility of epithelial cells in healing processes
CC (motogen) (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer. Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250|UniProtKB:Q07654}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q07654}.
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DR EMBL; AY264844; AAP21821.1; -; mRNA.
DR RefSeq; NP_001002990.1; NM_001002990.1.
DR AlphaFoldDB; Q863B4; -.
DR SMR; Q863B4; -.
DR STRING; 9612.ENSCAFP00000032737; -.
DR PaxDb; Q863B4; -.
DR Ensembl; ENSCAFT00000109373; ENSCAFP00000074539; ENSCAFG00000053768.
DR Ensembl; ENSCAFT00030041012; ENSCAFP00030035787; ENSCAFG00030022325.
DR Ensembl; ENSCAFT00040045961; ENSCAFP00040040100; ENSCAFG00040024680.
DR Ensembl; ENSCAFT00845054078; ENSCAFP00845042482; ENSCAFG00845030487.
DR GeneID; 403488; -.
DR KEGG; cfa:403488; -.
DR CTD; 7033; -.
DR VEuPathDB; HostDB:ENSCAFG00845030487; -.
DR eggNOG; ENOG502SV7V; Eukaryota.
DR GeneTree; ENSGT00940000162416; -.
DR InParanoid; Q863B4; -.
DR OrthoDB; 1563185at2759; -.
DR Proteomes; UP000002254; Chromosome 31.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030277; P:maintenance of gastrointestinal epithelium; IBA:GO_Central.
DR GO; GO:0010906; P:regulation of glucose metabolic process; IEA:Ensembl.
DR CDD; cd00111; Trefoil; 1.
DR Gene3D; 4.10.110.10; -; 1.
DR InterPro; IPR017994; P_trefoil_chordata.
DR InterPro; IPR017957; P_trefoil_CS.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR PANTHER; PTHR13826; PTHR13826; 1.
DR Pfam; PF00088; Trefoil; 1.
DR PRINTS; PR00680; PTREFOIL.
DR SMART; SM00018; PD; 1.
DR SUPFAM; SSF57492; SSF57492; 1.
DR PROSITE; PS00025; P_TREFOIL_1; 1.
DR PROSITE; PS51448; P_TREFOIL_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Disulfide bond; Extracellular matrix; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..80
FT /note="Trefoil factor 3"
FT /id="PRO_0000023464"
FT DOMAIN 30..73
FT /note="P-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 32..58
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 42..57
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 52..69
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 78
FT /note="Interchain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
SQ SEQUENCE 80 AA; 8865 MW; 9BEFD90482647183 CRC64;
MEARVLWLLV VVLVLGSSSL AVAYQGLATN LCEVPPKDRV DCGYPEITSE QCVNRGCCFD
SSIHGVPWCF KPLQDTECRF
