TFF3_FELCA
ID TFF3_FELCA Reviewed; 80 AA.
AC B4X8D9;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 46.
DE RecName: Full=Trefoil factor 3;
DE AltName: Full=Intestinal trefoil factor;
DE Flags: Precursor;
GN Name=TFF3; Synonyms=ITF;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Colon mucosa;
RA Campbell B.G., Jabbes M.;
RT "Nucleotide and deduced amino acid sequences of feline trefoil peptides
RT TFF1, TFF2, and TFF3.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the maintenance and repair of the intestinal
CC mucosa. Promotes the mobility of epithelial cells in healing processes
CC (motogen) (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer. Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250|UniProtKB:Q07654}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q07654}.
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DR EMBL; EF487347; ABS11940.1; -; mRNA.
DR EMBL; EF487350; ABS11943.1; -; mRNA.
DR EMBL; EF487353; ABS11946.1; -; mRNA.
DR RefSeq; NP_001123862.1; NM_001130390.1.
DR AlphaFoldDB; B4X8D9; -.
DR SMR; B4X8D9; -.
DR STRING; 9685.ENSFCAP00000016668; -.
DR Ensembl; ENSFCAT00000032524; ENSFCAP00000016668; ENSFCAG00000029722.
DR GeneID; 100170655; -.
DR KEGG; fca:100170655; -.
DR CTD; 7033; -.
DR VGNC; VGNC:66121; TFF3.
DR eggNOG; ENOG502SV7V; Eukaryota.
DR GeneTree; ENSGT00940000162416; -.
DR InParanoid; B4X8D9; -.
DR OrthoDB; 1563185at2759; -.
DR Proteomes; UP000011712; Chromosome C2.
DR Bgee; ENSFCAG00000029722; Expressed in liver and 5 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030277; P:maintenance of gastrointestinal epithelium; IBA:GO_Central.
DR GO; GO:0010906; P:regulation of glucose metabolic process; IEA:Ensembl.
DR CDD; cd00111; Trefoil; 1.
DR Gene3D; 4.10.110.10; -; 1.
DR InterPro; IPR017994; P_trefoil_chordata.
DR InterPro; IPR017957; P_trefoil_CS.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR PANTHER; PTHR13826; PTHR13826; 1.
DR Pfam; PF00088; Trefoil; 1.
DR PRINTS; PR00680; PTREFOIL.
DR SMART; SM00018; PD; 1.
DR SUPFAM; SSF57492; SSF57492; 1.
DR PROSITE; PS00025; P_TREFOIL_1; 1.
DR PROSITE; PS51448; P_TREFOIL_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Disulfide bond; Extracellular matrix; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..80
FT /note="Trefoil factor 3"
FT /id="PRO_0000376810"
FT DOMAIN 30..73
FT /note="P-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 32..58
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 42..57
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 52..69
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 78
FT /note="Interchain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
SQ SEQUENCE 80 AA; 8799 MW; EE99A47080263957 CRC64;
MEARVLWLLA LVLALGSSSL ADQYVGLSEN LCAVPAKNRV DCGYPEISPE QCVNRGCCFD
SSIPEVPWCF KPLQDTECTF
